Results 31 to 40 of about 58,781 (291)
The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation
Iranian Journal of Allergy, Asthma and Immunology, 2022 Immune reconstitution after hematopoietic stem cell transplantation (HSCT) with a conditioning regimen has appeared to be a promising treatment for autoimmune diseases and hematologic malignancies.
Fahimeh Zamani +8 more
doaj +1 more source
Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach [PDF]
, 2015 A highly diverse T-cell receptor (TCR) repertoire is a fundamental property of an effective immune system, and is associated with efficient control of viral infections and other pathogens. However, direct measurement of total TCR diversity is impossible.
Asquith, RE, Bangham, C, Laydon, D
core +1 more source
Characterization of the T cell receptor repertoire causing collagen arthritis in mice [PDF]
, 1993 Collagen type II-induced arthritis (CIA) is generated in susceptible rodent strains by intradermal injections of homologous or heterologous native type II collagen in complete Freund's adjuvant.
Hood, Leroy E. +3 more
core +2 more sources
The TCR δ Repertoire in Normal Human Skin is Restricted and Distinct from the TCR δ Repertoire in the Peripheral Blood [PDF]
Journal of Investigative Dermatology, 2001 The skin and the intestinal mucosa form surfaces to external environments and share similarities in anatomic structure and immunologic defense. In healthy humans, intestinal gamma/delta T cells express a highly restricted gamma/delta T cell receptor repertoire whereas gamma/delta T cells of the skin were thought to express a polyclonal repertoire ...
Holtmeier, Wolfgang +5 more
openaire +2 more sources
Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice [PDF]
The Journal of Immunology, 2016 Abstract Currently, there is little consensus regarding the most appropriate animal model to study acute infection and the virus-specific CD8+ T cell (CTL) responses in neonates. TCRβ high-throughput sequencing in naive CTL of differently aged neonatal mice was performed, which demonstrated differential Vβ family gene usage.
Alison J Carey +9 more
openaire +2 more sources
The Journal of Clinical Investigation, 2022 A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age.
Xiaoping Sun +17 more
doaj +1 more source
Exploring the potential of the TCR repertoire as a tumor biomarker (Review). [PDF]
Oncol LettT cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T-cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells.
Huang AL +5 more
europepmc +3 more sources
OncoImmunology, 2022 T cell receptor (TCR) repertoire as a biomarker for predicting immunotherapy efficiency has been widely studied. However, its dynamics during radiotherapy combined with PD-1 blockade is little known. Using paired tumor and blood samples from the phase Ib
Cihui Yan +15 more
doaj +1 more source
End stage renal disease patients have a skewed T cell receptor Vβ repertoire [PDF]
, 2015 Background: End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) Vβ repertoire is central to effective T-cell mediated immune responses to foreign antigens.
Baan, C.C. (Carla) +6 more
core +1 more source
Deciphering the TCR Repertoire to Solve the COVID-19 Mystery [PDF]
Trends in Pharmacological Sciences, 2020 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date. Important questions have remained unanswered: why some patients develop severe disease, while others do not; and what roles do genetic variabilities play in the individual immune response to this ...
Gutierrez, Lucas +2 more
openaire +2 more sources