Results 31 to 40 of about 34,505 (262)

Chasing the chains by testing them twice: Immunological insights from TCR repertoire analysis [PDF]

, 2023
The adaptive immune system employs a large number of T cells, that each have a specificity defined by their T-cell receptor (TCR). Characterizing the TCR repertoire in humans and mice thus provides a way to address outstanding immunological questions ...
de Greef, Peter Cornelis
core   +2 more sources

Longitudinal analysis reveals age-related changes in the T cell receptor repertoire of human T cell subsets

The Journal of Clinical Investigation, 2022
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age.
Xiaoping Sun, Thomas Nguyen, Achouak Achour, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyoko Hiroi, Yongqing Zhang, Chee W. Chia, William Wood III, Wells W. Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rong-Fong Shen, Luigi Ferrucci, Nan-ping Weng   +17 more
doaj   +1 more source

Analysis of the paired TCR α- and β-chains of single human T cells. [PDF]

, 2012
Analysis of the paired i.e. matching TCR α- and β-chain rearrangements of single human T cells is required for a precise investigation of clonal diversity, tissue distribution and specificity of protective and pathologic T-cell mediated immune responses.
Dornmair, K., Besgen, P., Held, K., Bhonsle, L., Vollmer, Sigrid, Song-Min Kim, Jens Nickel, Anna Backes, Held, Kathrin, Vollmer, S., Joerg C Prinz, Backes Anna, Backes, A., Backes, Anna, Bhonsle, Latika, Kim Song-Min, Nickel, Jens, Sigrid Vollmer, Nickel, J., Kim, Song-Min, Klaus Dornmair, Dornmair, Klaus, Kim, S., Besgen Petra, Petra Besgen, Vollmer Sigrid, Prinz, Joerg C., Prinz Joerg C., Latika Bhonsle, Bhonsle Latika, Besgen, Petra, Held Kathrin, Prinz, J., Kathrin Held, Nickel Jens, Dornmair Klaus   +35 more
core   +1 more source

Time-spatial analysis of T cell receptor repertoire in esophageal squamous cell carcinoma patients treated with combined radiotherapy and PD-1 blockade

OncoImmunology, 2022
T cell receptor (TCR) repertoire as a biomarker for predicting immunotherapy efficiency has been widely studied. However, its dynamics during radiotherapy combined with PD-1 blockade is little known. Using paired tumor and blood samples from the phase Ib
Cihui Yan, Xiaoxue Ma, Zhoubo Guo, Xiaoying Wei, Dong Han, Tian Zhang, Xi Chen, Fuliang Cao, Jie Dong, Gang Zhao, Xuan Gao, Tao Wang, Yao Jiang, Ping Wang, Qingsong Pang, Wencheng Zhang   +15 more
doaj   +1 more source

Deciphering the TCR Repertoire to Solve the COVID-19 Mystery [PDF]

Trends in Pharmacological Sciences, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date. Important questions have remained unanswered: why some patients develop severe disease, while others do not; and what roles do genetic variabilities play in the individual immune response to this ...
Gutierrez, Lucas, Beckford, John, Alachkar, Houda   +2 more
openaire   +2 more sources

Studies of suppression using monoclonal regulatory T cells and the importance of co-receptor Lck coupling ratios for negative selection [PDF]

, 2015
Normal physiology is not given without immunological tolerance. Depending on the origin of induction, tolerance can be divided into central and peripheral tolerance.
Gubser, Céline
core   +1 more source

Studies on the affinity control of T cell development [PDF]

, 2004
Defined interactions between thymocytes and thymic antigen presenting cells ensure that each T cell found in an individual is both self-restricted and self-tolerant.
Naeher, Dieter
core   +1 more source

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E., Heufelder, Armin E., Scriba, Peter C.   +2 more
core   +1 more source

The splenic T cell receptor repertoire during an immune response against a complex antigen: Expanding private clones accumulate in the high and low copy number region.

PLoS ONE, 2022
Large cellular antigens comprise a variety of different epitopes leading to a T cell response of extreme diversity. Therefore, tracking such a response by next generation sequencing of the T cell receptor (TCR) in order to identify common TCR properties ...
Martin Meinhardt, Cornelia Tune, Lisa-Kristin Schierloh, Andrea Schampel, René Pagel, Jürgen Westermann   +5 more
doaj   +1 more source

Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Frontiers in Immunology, 2021
T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity.
Roberta Amoriello, Alice Mariottini, Clara Ballerini   +2 more
doaj   +1 more source