Results 31 to 40 of about 206,427 (253)

Human γδ TCR Repertoires in Health and Disease [PDF]

Cells, 2020
The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ
Alina Suzann Fichtner, Sarina Ravens, Immo Prinz   +2 more
openaire   +3 more sources

TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes

BMC Bioinformatics, 2022
Background T cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to examine the T cell receptor (TCR) repertoire at the individual sequence level.
Meiling Liu, Juna Goo, Yang Liu, Wei Sun, Michael C. Wu, Li Hsu, Qianchuan He   +6 more
doaj   +1 more source

Huge Overlap of Individual TCR Beta Repertoires [PDF]

Frontiers in Immunology, 2013
It has been reported that human TCR repertoires commonly carry so-called public clonotypes – CDR3 variants that are often shared between individuals. Cross-comparison of individual immune repertoires has previously revealed the existence of a population of TCR beta CDR3 variants that are identical at the amino acid level for any two donors (1–3).
Mikhail eShugay, Dmitriy A Bolotin, Ekaterina V Putintseva, Mikhail V Pogorelyy, Ilgar Z Mamedov, Ilgar Z Mamedov, Dmitriy M Chudakov, Dmitriy M Chudakov   +7 more
openaire   +3 more sources

Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis

Frontiers in Immunology, 2022
CD8+ T cells are the key effector cells that contribute to the antitumor immune response. They comprise various T-cell clones with diverse antigen-specific T-cell receptors (TCRs).
Hiroyasu Aoki, Hiroyasu Aoki, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha   +4 more
doaj   +1 more source

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Frontiers in Immunology, 2020
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the ...
Meriem Attaf, Meriem Attaf, Julia Roider, Julia Roider, Julia Roider, Julia Roider, Amna Malik, Cristina Rius Rafael, Cristina Rius Rafael, Garry Dolton, Garry Dolton, Andrew J. Predergast, Andrew J. Predergast, Andrew J. Predergast, Alasdair Leslie, Alasdair Leslie, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Henrik N. Kløverpris, Henrik N. Kløverpris, Andrew K. Sewell, Andrew K. Sewell, Philip J. Goulder, Philip J. Goulder   +26 more
doaj   +1 more source

T‐cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications

Cancer Communications, 2020
T cells, which are involved in adaptive immunity, are essential in the elimination of tumor cells. Mature T cells can specifically recognize the antigen on the major histocompatibility complex (MHC) molecule through T‐cell receptors (TCR).
Na Li, Jiani Yuan, Wenjia Tian, Lin Meng, Yongyu Liu   +4 more
doaj   +1 more source

Enterovirus 71 Infection Shapes Host T Cell Receptor Repertoire and Presumably Expands VP1-Specific TCRβ CDR3 Cluster

Pathogens, 2020
Enterovirus 71 (EV71) has become an important public health problem in the Asia-Pacific region in the past decades. EV71 infection might cause neurological and psychiatric complications and even death. Although an EV71 vaccine has been currently approved,
Yu-Wen Liao, Bing-Ching Ho, Min-Hsuan Chen, Sung-Liang Yu   +3 more
doaj   +1 more source

Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity. [PDF]

PLoS ONE, 2012
BACKGROUND: The importance of CD4⁺ and CD8⁺ T cells in protection against tuberculosis (TB) is well known, however, the association between changes to the T cell repertoire and disease presentation has never been analyzed.
Wei Luo, Jin Su, Xiao-Bing Zhang, Zhi Yang, Ming-Qian Zhou, Zhen-Min Jiang, Pei-Pei Hao, Su-Dong Liu, Qian Wen, Qi Jin, Li Ma   +10 more
doaj   +1 more source

The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation

Iranian Journal of Allergy, Asthma and Immunology, 2022
Immune reconstitution after hematopoietic stem cell transplantation (HSCT) with a conditioning regimen has appeared to be a promising treatment for autoimmune diseases and hematologic malignancies.
Fahimeh Zamani, Reza Mirfakhraie, Sayyed Reza Safaee Nodehi, Yaghoub Mollaei-Kandelous, Hossein Jafari, Mohammad Farahmand, Farhad Rezaei, Majid Teymoori-Rad, Abolfazl Movafagh   +8 more
doaj   +1 more source

Regional and global changes in TCR [alpha][beta] T cell repertoires in the gut are dependent upon the complexity of the enteric microflora [PDF]

, 2010
The repertoire of gut associated T cells is shaped by exposure to microbes, including the natural enteric microflora. Previous studies compared the repertoire of gut associated T cell populations in germ free (GF) and conventional mammals often focussing
Beal, R.K., Smith, A.L., Tom Humphrey, Friedman, A., Friedman, A, Beal, RK, Bailey, M, Adrian L. Smith, Humphrey, T., Claire Powers, Wu, X, Bailey, M., William N. Mwangi, Mwangi, WN, Smith, Adrian, Watson, M, Xikun Wu, Mwangi, W.N., Richard K. Beal, Michael Watson, Humphrey, TJ, Wu, X., Humphrey, T, Watson, Mick, Smith, AL, Aharon Friedman, Powers, C, Powers, C., Michael Bailey   +28 more
core   +1 more source