Results 31 to 40 of about 30,633 (227)

Time-spatial analysis of T cell receptor repertoire in esophageal squamous cell carcinoma patients treated with combined radiotherapy and PD-1 blockade

OncoImmunology, 2022
T cell receptor (TCR) repertoire as a biomarker for predicting immunotherapy efficiency has been widely studied. However, its dynamics during radiotherapy combined with PD-1 blockade is little known. Using paired tumor and blood samples from the phase Ib
Cihui Yan, Xiaoxue Ma, Zhoubo Guo, Xiaoying Wei, Dong Han, Tian Zhang, Xi Chen, Fuliang Cao, Jie Dong, Gang Zhao, Xuan Gao, Tao Wang, Yao Jiang, Ping Wang, Qingsong Pang, Wencheng Zhang   +15 more
doaj   +1 more source

The splenic T cell receptor repertoire during an immune response against a complex antigen: Expanding private clones accumulate in the high and low copy number region.

PLoS ONE, 2022
Large cellular antigens comprise a variety of different epitopes leading to a T cell response of extreme diversity. Therefore, tracking such a response by next generation sequencing of the T cell receptor (TCR) in order to identify common TCR properties ...
Martin Meinhardt, Cornelia Tune, Lisa-Kristin Schierloh, Andrea Schampel, René Pagel, Jürgen Westermann   +5 more
doaj   +1 more source

Characterization of human T cell receptor repertoire data in eight thymus samples and four related blood samples

Data in Brief, 2021
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive ...
Nelli Heikkilä, Iivari Kleino, Reetta Vanhanen, Dawit A. Yohannes, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila   +6 more
doaj   +1 more source

The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse

Scientific Reports, 2021
The self-antigen α-synuclein (α-syn) was recently shown to be associated with Parkinson’s disease (PD). Here we mapped the T cell receptor (TCR) repertoire of α-syn-specific T cells from six PD patients.
Akul Singhania, John Pham, Rekha Dhanwani, April Frazier, Juliana Rezende Dutra, Karen S. Marder, Elizabeth Phillips, Simon Mallal, Amy W. Amara, David G. Standaert, David Sulzer, Bjoern Peters, Alessandro Sette, Cecilia S. Lindestam Arlehamn   +13 more
doaj   +1 more source

Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Frontiers in Immunology, 2021
T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity.
Roberta Amoriello, Alice Mariottini, Clara Ballerini   +2 more
doaj   +1 more source

Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR Repertoire [PDF]

The Journal of Immunology, 2011
Abstract Defects in T cell responses against pathogens and reduced diversity of TCRs have been described at both extremes of the life span. Yet, we still lack information on how Ag-specific T cell populations are maintained and/or altered from birth to old age.
Brian D, Rudd, Vanessa, Venturi, Miles P, Davenport, Janko, Nikolich-Zugich   +3 more
openaire   +2 more sources

System-wide Analysis of the T Cell Response

Cell Reports, 2016
The T cell receptor (TCR) controls the cellular adaptive immune response to antigens, but our understanding of TCR repertoire diversity and response to challenge is still incomplete.
Ruxandra Covacu, Hagit Philip, Merja Jaronen, Jorge Almeida, Jessica E. Kenison, Samuel Darko, Chun-Cheih Chao, Gur Yaari, Yoram Louzoun, Liran Carmel, Daniel C. Douek, Sol Efroni, Francisco J. Quintana   +12 more
doaj   +1 more source

Autoencoder based local T cell repertoire density can be used to classify samples and T cell receptors.

PLoS Computational Biology, 2021
Recent advances in T cell repertoire (TCR) sequencing allow for the characterization of repertoire properties, as well as the frequency and sharing of specific TCR. However, there is no efficient measure for the local density of a given TCR.
Shirit Dvorkin, Reut Levi, Yoram Louzoun
doaj   +1 more source

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

ImmunoInformatics, 2022
T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The expression of TCRs is usually measured with targeted sequencing approaches where TCR genes are selectively amplified.
Teresa Rubio, Maria Chernigovskaya, Susanna Marquez, Cristina Marti, Paula Izquierdo-Altarejos, Amparo Urios, Carmina Montoliu, Vicente Felipo, Ana Conesa, Victor Greiff, Sonia Tarazona   +10 more
doaj   +1 more source

Individual Epitope-Specific CD8⁺ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection

Pathogens, 2023
A hallmark in chronic viral infections are exhausted antigen-specific CD8+ T cell responses and the inability of the immune system to eliminate the virus.
Sebastian Klein, Jasmin Mischke, Finn Beruldsen, Immo Prinz, Dinler A. Antunes, Markus Cornberg, Anke R. M. Kraft   +6 more
doaj   +1 more source