Results 41 to 50 of about 34,505 (262)

The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse

Scientific Reports, 2021
The self-antigen α-synuclein (α-syn) was recently shown to be associated with Parkinson’s disease (PD). Here we mapped the T cell receptor (TCR) repertoire of α-syn-specific T cells from six PD patients.
Akul Singhania, John Pham, Rekha Dhanwani, April Frazier, Juliana Rezende Dutra, Karen S. Marder, Elizabeth Phillips, Simon Mallal, Amy W. Amara, David G. Standaert, David Sulzer, Bjoern Peters, Alessandro Sette, Cecilia S. Lindestam Arlehamn   +13 more
doaj   +1 more source

Characterization of human T cell receptor repertoire data in eight thymus samples and four related blood samples

Data in Brief, 2021
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive ...
Nelli Heikkilä, Iivari Kleino, Reetta Vanhanen, Dawit A. Yohannes, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila   +6 more
doaj   +1 more source

TCR repertoire dynamics and their responses underscores dengue severity. [PDF]

iScience
Despite recognizing the immune response's role in dengue progression, the intricate dynamics of T cell receptor (TCR) variations across DENV infection severities remain elusive. This study addresses this gap by analyzing in-house generated RNA-seq data from 112 dengue patients with varying disease severities.
Khare K, Yadav S, Tarai B, Budhiraja S, Pandey R.   +4 more
europepmc   +4 more sources

System-wide Analysis of the T Cell Response

Cell Reports, 2016
The T cell receptor (TCR) controls the cellular adaptive immune response to antigens, but our understanding of TCR repertoire diversity and response to challenge is still incomplete.
Ruxandra Covacu, Hagit Philip, Merja Jaronen, Jorge Almeida, Jessica E. Kenison, Samuel Darko, Chun-Cheih Chao, Gur Yaari, Yoram Louzoun, Liran Carmel, Daniel C. Douek, Sol Efroni, Francisco J. Quintana   +12 more
doaj   +1 more source

Autoencoder based local T cell repertoire density can be used to classify samples and T cell receptors.

PLoS Computational Biology, 2021
Recent advances in T cell repertoire (TCR) sequencing allow for the characterization of repertoire properties, as well as the frequency and sharing of specific TCR. However, there is no efficient measure for the local density of a given TCR.
Shirit Dvorkin, Reut Levi, Yoram Louzoun
doaj   +1 more source

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

ImmunoInformatics, 2022
T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The expression of TCRs is usually measured with targeted sequencing approaches where TCR genes are selectively amplified.
Teresa Rubio, Maria Chernigovskaya, Susanna Marquez, Cristina Marti, Paula Izquierdo-Altarejos, Amparo Urios, Carmina Montoliu, Vicente Felipo, Ana Conesa, Victor Greiff, Sonia Tarazona   +10 more
doaj   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

Individual Epitope-Specific CD8⁺ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection

Pathogens, 2023
A hallmark in chronic viral infections are exhausted antigen-specific CD8+ T cell responses and the inability of the immune system to eliminate the virus.
Sebastian Klein, Jasmin Mischke, Finn Beruldsen, Immo Prinz, Dinler A. Antunes, Markus Cornberg, Anke R. M. Kraft   +6 more
doaj   +1 more source

Diversity of TCR repertoire predicts recurrence after CRT followed by durvalumab in patients with NSCLC. [PDF]

NPJ Precis Oncol
Chemoradiotherapy (CRT) followed by durvalumab is standard for unresectable locally advanced non-small-cell lung cancer (LA-NSCLC). This study assesses how CRT alters the T-cell receptor (TCR) repertoire in CD8 + PD-1 + T-cells and its impact on clinical
Shirasawa M, Yoshida T, Matsutani T, Takeyasu Y, Goto N, Yagishita S, Kitano S, Kuroda H, Hida T, Kurata T, Ohe Y.   +10 more
europepmc   +2 more sources

A Long-Playing CD about the γδ TCR Repertoire [PDF]

Immunity, 2013
In this issue of Immunity, a study by Luoma et al. (2013) provides structural evidence for direct interactions of human Vδ1(+) T cell receptors with CD1d, capping a long trail of evidence that CD1 might be a major influence on γδ T cell biology.
Hayday, Adrian, Vantourout, Pierre
openaire   +3 more sources