Results 41 to 50 of about 58,781 (291)

Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective [PDF]

, 2015
Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression.
Ono, M, Tanaka, RJ
core   +1 more source

DIPG-32. NEOANTIGEN HEAT SHOCK PROTEIN VACCINE, RHSC-DIPGVAX, IS ASSOCIATED WITH INCREASED VACCINE-INDUCED B CELLS AND BCR/TCR REPERTOIRE DIVERSITY IN PEDIATRIC PATIENTS WITH DIFFUSE MIDLINE GLIOMAS [PDF]

Neuro Oncol
Lauren Boland, Si Wang, Slim Fourati, Suzi Delay, Tzu-Yi Chia, Leah Billingham, Joshua Katz, Chao Wei, Yuheng Geng, Patrick Sipila, Aru Narendran, Susan Chi, Mariko Sato, Caty Lee-Chang, Jason Miska, Ashley Plant   +15 more
europepmc   +3 more sources

The splenic T cell receptor repertoire during an immune response against a complex antigen: Expanding private clones accumulate in the high and low copy number region.

PLoS ONE, 2022
Large cellular antigens comprise a variety of different epitopes leading to a T cell response of extreme diversity. Therefore, tracking such a response by next generation sequencing of the T cell receptor (TCR) in order to identify common TCR properties ...
Martin Meinhardt, Cornelia Tune, Lisa-Kristin Schierloh, Andrea Schampel, René Pagel, Jürgen Westermann   +5 more
doaj   +1 more source

Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Frontiers in Immunology, 2021
T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity.
Roberta Amoriello, Alice Mariottini, Clara Ballerini   +2 more
doaj   +1 more source

TCR repertoire dynamics and their responses underscores dengue severity. [PDF]

iScience
Despite recognizing the immune response's role in dengue progression, the intricate dynamics of T cell receptor (TCR) variations across DENV infection severities remain elusive. This study addresses this gap by analyzing in-house generated RNA-seq data from 112 dengue patients with varying disease severities.
Khare K, Yadav S, Tarai B, Budhiraja S, Pandey R.   +4 more
europepmc   +4 more sources

Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR Repertoire [PDF]

The Journal of Immunology, 2011
Abstract Defects in T cell responses against pathogens and reduced diversity of TCRs have been described at both extremes of the life span. Yet, we still lack information on how Ag-specific T cell populations are maintained and/or altered from birth to old age.
Brian D, Rudd, Vanessa, Venturi, Miles P, Davenport, Janko, Nikolich-Zugich   +3 more
openaire   +2 more sources

The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse

Scientific Reports, 2021
The self-antigen α-synuclein (α-syn) was recently shown to be associated with Parkinson’s disease (PD). Here we mapped the T cell receptor (TCR) repertoire of α-syn-specific T cells from six PD patients.
Akul Singhania, John Pham, Rekha Dhanwani, April Frazier, Juliana Rezende Dutra, Karen S. Marder, Elizabeth Phillips, Simon Mallal, Amy W. Amara, David G. Standaert, David Sulzer, Bjoern Peters, Alessandro Sette, Cecilia S. Lindestam Arlehamn   +13 more
doaj   +1 more source

Characterization of human T cell receptor repertoire data in eight thymus samples and four related blood samples

Data in Brief, 2021
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive ...
Nelli Heikkilä, Iivari Kleino, Reetta Vanhanen, Dawit A. Yohannes, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila   +6 more
doaj   +1 more source

System-wide Analysis of the T Cell Response

Cell Reports, 2016
The T cell receptor (TCR) controls the cellular adaptive immune response to antigens, but our understanding of TCR repertoire diversity and response to challenge is still incomplete.
Ruxandra Covacu, Hagit Philip, Merja Jaronen, Jorge Almeida, Jessica E. Kenison, Samuel Darko, Chun-Cheih Chao, Gur Yaari, Yoram Louzoun, Liran Carmel, Daniel C. Douek, Sol Efroni, Francisco J. Quintana   +12 more
doaj   +1 more source

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

ImmunoInformatics, 2022
T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The expression of TCRs is usually measured with targeted sequencing approaches where TCR genes are selectively amplified.
Teresa Rubio, Maria Chernigovskaya, Susanna Marquez, Cristina Marti, Paula Izquierdo-Altarejos, Amparo Urios, Carmina Montoliu, Vicente Felipo, Ana Conesa, Victor Greiff, Sonia Tarazona   +10 more
doaj   +1 more source