Results 1 to 10 of about 96,959 (285)

T cell receptor repertoire analysis in HTLV-1-associated diseases

Frontiers in Immunology, 2022
Human T lymphotropic virus 1 (HTLV-1) is a human retrovirus identified as the causative agent in adult T-cell leukemia/lymphoma (ATL) and chronic-progressive neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP ...
Annaliese Clauze, Yoshimi Enose-Akahata, Steven Jacobson   +2 more
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Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment

Frontiers in Immunology, 2021
ObjectiveIn people living with HIV (PLHIV), we sought to test the hypothesis that long term anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional relationship of residual repertoire abnormalities to persistent ...
Carolin T. Turner, James Brown, James Brown, Emily Shaw, Imran Uddin, Evdokia Tsaliki, Jennifer K. Roe, Gabriele Pollara, Yuxin Sun, James M. Heather, Marc Lipman, Marc Lipman, Benny Chain, Mahdad Noursadeghi   +13 more
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Premature Infants Have Normal Maturation of the T Cell Receptor Repertoire at Term

Frontiers in Immunology, 2022
Premature infants are known to have immature immune systems compared to term infants; however, the impacts of ex utero immune development are not well characterized.
Sarah U. Morton, Sarah U. Morton, Maureen Schnur, Rylee Kerper, Vanessa Young, Amy E. O’Connell, Amy E. O’Connell, Amy E. O’Connell   +7 more
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The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Frontiers in Immunology, 2023
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections, and ...
Melissa Pille, John Avila, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Glenn Goetgeluk, Glenn Goetgeluk, Stijn De Munter, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Sarah Bonte, Joline Ingels, Joline Ingels, Laurenz De Cock, Laurenz De Cock, Eva Pascal, Eva Pascal, Lucas Deseins, Lucas Deseins, Tessa Kerre, Tessa Kerre, Tom Taghon, Tom Taghon, Georges Leclercq, Georges Leclercq, David Vermijlen, David Vermijlen, David Vermijlen, David Vermijlen, Brian Davis, Bart Vandekerckhove, Bart Vandekerckhove   +36 more
doaj   +1 more source

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Frontiers in Immunology, 2020
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the ...
Meriem Attaf, Meriem Attaf, Julia Roider, Julia Roider, Julia Roider, Julia Roider, Amna Malik, Cristina Rius Rafael, Cristina Rius Rafael, Garry Dolton, Garry Dolton, Andrew J. Predergast, Andrew J. Predergast, Andrew J. Predergast, Alasdair Leslie, Alasdair Leslie, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Henrik N. Kløverpris, Henrik N. Kløverpris, Andrew K. Sewell, Andrew K. Sewell, Philip J. Goulder, Philip J. Goulder   +26 more
doaj   +1 more source

Comparative Study of Repertoire Classification Methods Reveals Data Efficiency of k-mer Feature Extraction

Frontiers in Immunology, 2022
The repertoire of T cell receptors encodes various types of immunological information. Machine learning is indispensable for decoding such information from repertoire datasets measured by next-generation sequencing (NGS).
Yotaro Katayama, Tetsuya J. Kobayashi
doaj   +1 more source

Single-cell RNA-seq revealing the immune features of donor liver during liver transplantation

Frontiers in Immunology, 2023
Immune cells, including T and B cells, are key factors in the success of liver transplantation. And the repertoire of T cells and B cells plays an essential function in mechanism of the immune response associated with organ transplantation.
Yi Shan, Debin Qi, Lei Zhang, Lixue Wu, Wenfang Li, Hao Liu, Tao Li, Zhiren Fu, Haili Bao, Shaohua Song   +9 more
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The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation

Iranian Journal of Allergy, Asthma and Immunology, 2022
Immune reconstitution after hematopoietic stem cell transplantation (HSCT) with a conditioning regimen has appeared to be a promising treatment for autoimmune diseases and hematologic malignancies.
Fahimeh Zamani, Reza Mirfakhraie, Sayyed Reza Safaee Nodehi, Yaghoub Mollaei-Kandelous, Hossein Jafari, Mohammad Farahmand, Farhad Rezaei, Majid Teymoori-Rad, Abolfazl Movafagh   +8 more
doaj   +1 more source

Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq

Scientific Reports, 2023
Thymic T cell development comprises T cell receptor (TCR) recombination and assessment of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells.
Marte Heimli, Siri Tennebø Flåm, Hanne Sagsveen Hjorthaug, Pål Marius Bjørnstad, Maria Chernigovskaya, Quy Khang Le, Xavier Tekpli, Victor Greiff, Benedicte Alexandra Lie   +8 more
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Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

eLife, 2022
Antigen recognition through the T cell receptor (TCR) αβ heterodimer is one of the primary determinants of the adaptive immune response. Vaccines activate naïve T cells with high specificity to expand and differentiate into memory T cells.
George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi   +18 more
doaj   +1 more source