Architecture of the SARS-CoV-2-specific T cell repertoire [PDF]
Frontiers in Immunology, 2023 The T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of ...
Ksenia V. Zornikova +7 more
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Tracking the T cell repertoire [PDF]
Nature Reviews Immunology, 2015 Ron Germain describes two seminal papers by Marc Jenkins and colleagues that introduced new techniques for analysis of the T cell repertoire.
Ronald N Germain
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Spatial heterogeneity of T cell repertoire across NSCLC tumors, tumor edges, adjacent and distant lung tissues [PDF]
OncoImmunology, 2023 Background A better understanding of T cells in lung cancer and their distribution across tumor-adjacent lungs and peripheral blood is needed to improve efficacy and minimize toxicity from immunotherapy to lung cancer patients.Methods Here, we performed ...
Qikang Hu +17 more
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T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort [PDF]
Scientific Reports, 2023 We set out to gain insight into peripheral blood B and T cell repertoires from 120 infants of the LoewenKIDS birth cohort to investigate potential determinants of early life respiratory infections.
Lisa Paschold +17 more
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Quantitative Annotations of T-Cell Repertoire Specificity
Briefings in Bioinformatics, 2023 Abstract The specificity of a T-cell receptor (TCR) repertoire determines personalized immune capacity. Existing methods have modeled the qualitative aspects of TCR specificity, while the quantitative aspects remained unaddressed. We developed a package, TCRanno, to quantify the specificity of TCR repertoires. We created deep-learning-
Luo J +6 more
europepmc +3 more sources
Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire [PDF]
Frontiers in ImmunologyIntroductionThis study provides an in-depth analysis of the diversity of the CD4 TCR CDR3β repertoire specific to influenza A (HA) and Epstein-Barr virus (EBNA) epitopes.MethodsEpitope-specific CD4 T cells from 13 healthy donors were enriched using a ...
Gautier Lhomme +6 more
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Premature Infants Have Normal Maturation of the T Cell Receptor Repertoire at Term
Frontiers in Immunology, 2022 Premature infants are known to have immature immune systems compared to term infants; however, the impacts of ex utero immune development are not well characterized.
Sarah U. Morton +7 more
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Perturbations of the T-cell immune repertoire in kidney transplant rejection
Frontiers in Immunology, 2022 In this cross-sectional and longitudinal analysis of mapping the T-cell repertoire in kidney transplant recipients, we have investigated and validated T-cell clonality, immune repertoire chronology at rejection, and contemporaneous allograft biopsy ...
Tara K. Sigdel +9 more
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Frontiers in Immunology, 2022 The repertoire of T cell receptors encodes various types of immunological information. Machine learning is indispensable for decoding such information from repertoire datasets measured by next-generation sequencing (NGS).
Yotaro Katayama, Tetsuya J. Kobayashi
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Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
Frontiers in Immunology, 2020 Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the ...
Meriem Attaf +26 more
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