T-cell repertoire diversity: friend or foe for protective antitumor response? [PDF]
J Exp Clin Cancer Res, 2022 Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach to investigate autologous and treatment-induced antitumor immune response. Technical and computational breakthroughs, including high throughput next-generation sequencing
Porciello N +4 more
europepmc +2 more sources
HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis
Cell, 2020 Summary The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS is limited.
Christian Münz +2 more
exaly +2 more sources
Architecture of the SARS-CoV-2-specific T cell repertoire [PDF]
Frontiers in Immunology, 2023 The T cell response plays an indispensable role in the early control and successful clearance of SARS-CoV-2 infection. However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of ...
Ksenia V. Zornikova +7 more
doaj +2 more sources
Comprehensive T cell repertoire characterization of non-small cell lung cancer
Nature Communications, 2020 Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tissue ...
Alexandre Reuben +57 more
doaj +2 more sources
T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis
Cell Reports, 2019 Summary: Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research ...
Caren Ramien +20 more
doaj +2 more sources
SELECTION OF THE T CELL REPERTOIRE
Annual Review of Immunology, 1999 ▪ Abstract Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level.
Sebzda, E +5 more
openaire +4 more sources
Spatial heterogeneity of T cell repertoire across NSCLC tumors, tumor edges, adjacent and distant lung tissues [PDF]
OncoImmunology, 2023 Background A better understanding of T cells in lung cancer and their distribution across tumor-adjacent lungs and peripheral blood is needed to improve efficacy and minimize toxicity from immunotherapy to lung cancer patients.Methods Here, we performed ...
Qikang Hu +17 more
doaj +2 more sources
T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort [PDF]
Scientific Reports, 2023 We set out to gain insight into peripheral blood B and T cell repertoires from 120 infants of the LoewenKIDS birth cohort to investigate potential determinants of early life respiratory infections.
Lisa Paschold +17 more
doaj +2 more sources
Quantitative Annotations of T-Cell Repertoire Specificity
Briefings in Bioinformatics, 2023 Abstract The specificity of a T-cell receptor (TCR) repertoire determines personalized immune capacity. Existing methods have modeled the qualitative aspects of TCR specificity, while the quantitative aspects remained unaddressed. We developed a package, TCRanno, to quantify the specificity of TCR repertoires. We created deep-learning-
Luo J +6 more
europepmc +4 more sources
Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire [PDF]
Frontiers in ImmunologyIntroductionThis study provides an in-depth analysis of the diversity of the CD4 TCR CDR3β repertoire specific to influenza A (HA) and Epstein-Barr virus (EBNA) epitopes.MethodsEpitope-specific CD4 T cells from 13 healthy donors were enriched using a ...
Gautier Lhomme +6 more
doaj +2 more sources