Results 31 to 40 of about 1,946,426 (304)

Tracking the T cell repertoire [PDF]

Nature Reviews Immunology, 2015
Ron Germain describes two seminal papers by Marc Jenkins and colleagues that introduced new techniques for analysis of the T cell repertoire.
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T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing

Haematologica, 2019
Alloreactivity or opportunistic infections following allogeneic stem cell transplantation are difficult to predict and contribute to post-transplantation mortality.
Cornelia S. Link-Rachner, Anne Eugster, Elke Rücker-Braun, Falk Heidenreich, Uta Oelschlägel, Andreas Dahl, Christian Klesse, Matthias Kuhn, Jan Moritz Middeke, Martin Bornhäuser, Ezio Bonifacio, Johannes Schetelig   +11 more
doaj   +1 more source

Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy

International Journal of Molecular Sciences, 2020
The T cells are key players of the response to checkpoint blockade immunotherapy (CBI) and monitoring the strength and specificity of antitumor T-cell reactivity remains a crucial but elusive component of precision immunotherapy. The entire assembly of T-
I. Aversa, D. Malanga, G. Fiume, C. Palmieri   +3 more
semanticscholar   +1 more source

Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL.

PLoS Pathogens, 2022
Reconstitution of the T cell repertoire after allogeneic stem cell transplantation is a long and often incomplete process. As a result, reactivation of Epstein-Barr virus (EBV) is a frequent complication that may be treated by adoptive transfer of donor ...
María Fernanda Lammoglia Cobo, Julia Ritter, Regina Gary, Volkhard Seitz, Josef Mautner, Michael Aigner, Simon Völkl, Stefanie Schaffer, Stephanie Moi, Anke Seegebarth, Heiko Bruns, Wolf Rösler, Kerstin Amann, Maike Büttner-Herold, Steffen Hennig, Andreas Mackensen, Michael Hummel, Andreas Moosmann, Armin Gerbitz   +18 more
doaj   +1 more source

Single-cell RNA-seq revealing the immune features of donor liver during liver transplantation

Frontiers in Immunology, 2023
Immune cells, including T and B cells, are key factors in the success of liver transplantation. And the repertoire of T cells and B cells plays an essential function in mechanism of the immune response associated with organ transplantation.
Yi Shan, Debin Qi, Lei Zhang, Lixue Wu, Wenfang Li, Hao Liu, Tao Li, Zhiren Fu, Haili Bao, Shaohua Song   +9 more
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T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma

Journal for ImmunoTherapy of Cancer, 2020
Background Malignant pleural mesothelioma (MPM) is a highly lethal malignancy in need for new treatment options. Although immunotherapies have been shown to boost a tumor-specific immune response, not all patients respond and prognostic biomarkers are ...
Niek de Vries, Joachim G J V Aerts, Paul L Klarenbeek, Heleen Vroman, Giulia Balzaretti, Robert A Belderbos, Menno van Nimwegen, Koen Bezemer, Robin Cornelissen, Ilse T G Niewold, Barbera D van Schaik, Antione H van Kampen, Rudi W Hendriks   +12 more
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T Cell Repertoires and Competitive Exclusion

Journal of Theoretical Biology, 1994
Self-renewal is generally thought to play a major role in the maintenance of the T-cell repertoire. Here we develop a set of mathematical models for T-cell activation by peptides on antigen presenting cells (APCs). We show that competition between T cells is inherent to the processes involved in T cells binding APCs.
Boer, R.J. de, Perelson, A.S.
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The LCMV gp33-specific memory T cell repertoire narrows with age

Immunity & Ageing, 2012
Background The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease.
Bunztman Adam, Vincent Benjamin G, Krovi Harsha, Steele Shaun, Frelinger Jeffrey A   +4 more
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Longitudinal analysis reveals age-related changes in the T cell receptor repertoire of human T cell subsets

The Journal of Clinical Investigation, 2022
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age.
Xiaoping Sun, Thomas Nguyen, Achouak Achour, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyoko Hiroi, Yongqing Zhang, Chee W. Chia, William Wood III, Wells W. Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rong-Fong Shen, Luigi Ferrucci, Nan-ping Weng   +17 more
doaj   +1 more source

Self-Determination in the T Cell Repertoire [PDF]

Immunity, 2015
The number of T cells specific for various antigens can vary dramatically. In this issue of Immunity, Nelson et al. (2015) report that these differences might be, at least in part, set by the number of cross-reactive self peptides encountered by T cells during development.
Birnbaum, Michael E., Garcia, K. Christopher   +1 more
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