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Immune tolerance

Zdravniški Vestnik, 2011
BACKGROUND Regulation of human immune system through mechanisms of immune tolerance is an exceptionally important part of the homeostasis that protects the integrity of our organism.
Matjaž Jeras, Urban Švajger
doaj   +6 more sources

Immune Tolerance Regulation Is Critical to Immune Homeostasis

Journal of Immunology Research
The body’s immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. This equilibrium, referred to as immune homeostasis, is paramount for overall health.
Lei Han, Tianxiang Wu, Qin Zhang, Anning Qi, Xiaohui Zhou   +4 more
doaj   +4 more sources

Influence of Innate Immunity on Immune Tolerance [PDF]

Acta Medica Academica, 2020
This review mainly focuses on the mechanisms of peripheral immune tolerance within the perspectives of innate immunity. Healthy immune response requires balanced interaction of the highly specialized elements of immunity within a harmony. Innate immunity
Akdis, Mubeccel, Ozdemir, Cevdet, Kucuksezer, Umut C, Akdis, Cezmi A   +3 more
core   +3 more sources

Immune tolerance in allergy

Current Opinion in Immunology, 2009
Research on the mechanisms of immune regulation in allergy and asthma has shown substantial progress in recent years and has led to a variety of allergen-specific therapeutic and preventive approaches.
Akdis, M, Mübeccel Akdis
core   +5 more sources

Immune tolerance : induction and disruption for therapeutic immune modulation

This study investigated the tolerance induction and disruption of immune tolerance as strategies for immune modulation. For induction of immune tolerance, novel monocyte-derived tolerogenic dendritic cells (ItolDCs) were generated, and their ability to ...
Dao Nyesiga, Gillian
core   +4 more sources

Approaches to Establishing Tolerance in Immune Mediated Diseases

Frontiers in Immunology, 2021
The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from
Michelle F. Huffaker, Srinath Sanda, Sindhu Chandran, Sharon A. Chung, E. William St. Clair, Gerald T. Nepom, Dawn E. Smilek   +6 more
doaj   +1 more source

Immune Tolerance and Transplantation [PDF]

Seminars in Oncology, 2012
Successful allogeneic hematopoietic stem cell transplantation (HSCT) and solid organ transplantation require development of a degree of immune tolerance against allogeneic antigens. T lymphocytes play a critical role in allograft rejection, graft failure, and graft-versus-host disease (GVHD).
Onder, Alpdogan, Marcel R M, van den Brink   +1 more
openaire   +2 more sources

Biomarkers and mechanisms of tolerance induction in food allergic patients drive new therapeutic approaches

Frontiers in Immunology, 2022
Immunotherapy for food-allergic patients has been effective in inducing desensitization in some populations, but long-term tolerance has remained an elusive target.
Carolyn H. Baloh, Carolyn H. Baloh, Michelle F. Huffaker, Tanya Laidlaw, Tanya Laidlaw   +4 more
doaj   +1 more source

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin

Nature Communications, 2023
Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood.
Qian Xiao, Joseph Mears, Aparna Nathan, Kazuyoshi Ishigaki, Yuriy Baglaenko, Noha Lim, Laura A. Cooney, Kristina M. Harris, Mark S. Anderson, David A. Fox, Dawn E. Smilek, James G. Krueger, Soumya Raychaudhuri   +12 more
doaj   +1 more source

Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor

Frontiers in Immunology, 2021
CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cytokines.
Bruce M. Hall, Bruce M. Hall, Rachael M. Hall, Rachael M. Hall, Giang T. Tran, Giang T. Tran, Catherine M. Robinson, Catherine M. Robinson, Paul L. Wilcox, Paul L. Wilcox, Prateek K. Rakesh, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Nirupama D. Verma, Suzanne J. Hodgkinson, Suzanne J. Hodgkinson   +17 more
doaj   +1 more source