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Immune Tolerance Regulation Is Critical to Immune Homeostasis
Journal of Immunology ResearchThe body’s immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. This equilibrium, referred to as immune homeostasis, is paramount for overall health.
Lei Han +4 more
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Advancements in immune tolerance [PDF]
Advanced Drug Delivery Reviews, 2008 In recent years, considerable attention has been given to immune tolerance and its potential clinical applications for the treatment of cancers and autoimmune diseases, and the prevention of allo-graft rejection and graft-versus-host diseases. Advances in our understanding of the underlying mechanisms of establishment and maintenance of immune ...
Ping-Ying Pan +2 more
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Zdravniški Vestnik, 2011 BACKGROUND Regulation of human immune system through mechanisms of immune tolerance is an exceptionally important part of the homeostasis that protects the integrity of our organism.
Matjaž Jeras, Urban Švajger
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Approaches to Establishing Tolerance in Immune Mediated Diseases
Frontiers in Immunology, 2021 The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from
Michelle F. Huffaker +6 more
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Immune Tolerance and Transplantation [PDF]
Seminars in Oncology, 2012 Successful allogeneic hematopoietic stem cell transplantation (HSCT) and solid organ transplantation require development of a degree of immune tolerance against allogeneic antigens. T lymphocytes play a critical role in allograft rejection, graft failure, and graft-versus-host disease (GVHD).
Onder, Alpdogan +1 more
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Frontiers in Immunology, 2022 Immunotherapy for food-allergic patients has been effective in inducing desensitization in some populations, but long-term tolerance has remained an elusive target.
Carolyn H. Baloh +4 more
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Frontiers in Immunology, 2021 CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cytokines.
Bruce M. Hall +17 more
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Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin
Nature Communications, 2023 Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood.
Qian Xiao +12 more
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The Immune Tolerance Network: tolerance at the crossroads [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 Immune tolerance therapies are designed to reprogramme immune cells in a highly specific fashion in order to eliminate pathogenic responses but preserve normal immune function. A concept that has tantalized immunologists for decades, tolerogenic therapies would replace current lifelong immunosuppressive regimens and their often debilitating side ...
J A, Bluestone, J, Matthews
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Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
Frontiers in Immunology, 2021 Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies.
Isabelle Serr +8 more
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