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BACKGROUND Regulation of human immune system through mechanisms of immune tolerance is an exceptionally important part of the homeostasis that protects the integrity of our organism. Whenever we talk about immune responses, we primarily consider them as an efficient activation of numerous factors enabling our cellular and humoral immunity to protect us
Matjaž Jeras, Urban Švajger
+6 more sources
The immune response to malaria in utero. [PDF]
Malaria causes tremendous early childhood morbidity and mortality, providing an urgent impetus for the development of a vaccine that is effective in neonates.
Feeney, Margaret E
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Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation [PDF]
Autoimmune diseases are driven by immune cells that recognize self-tissues. A major goal for treatment strategies for autoimmune diseases is to turn off or tolerize self-reactive immune cells such as CD4 T cells that coordinate tissue damage in many ...
A. David +38 more
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To respond or not to respond - a personal perspective of intestinal tolerance [PDF]
For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka +142 more
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Immunotronics - novel finite-state-machine architectures with built-in self-test using self-nonself differentiation [PDF]
A novel approach to hardware fault tolerance is demonstrated that takes inspiration from the human immune system as a method of fault detection. The human immune system is a remarkable system of interacting cells and organs that protect the body from ...
Bradley, D.W., Tyrrell, A.M.
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CD28 between tolerance and autoimmunity: The side effects of animal models [version 1; referees: 2 approved] [PDF]
Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity.
A Aruffo +57 more
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Histopathology of the gut in rheumatic diseases [PDF]
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F. +4 more
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Adaptive immunity in cancer immunology and therapeutics. [PDF]
Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution,
Lockley, M, Spurrell, EL
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Advancements in immune tolerance [PDF]
In recent years, considerable attention has been given to immune tolerance and its potential clinical applications for the treatment of cancers and autoimmune diseases, and the prevention of allo-graft rejection and graft-versus-host diseases. Advances in our understanding of the underlying mechanisms of establishment and maintenance of immune ...
Ping-Ying, Pan +3 more
openaire +2 more sources
Intestinal macromolecular transport supporting adaptive immunity [PDF]
The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
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