Results 21 to 30 of about 1,952,965 (303)
Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin
Nature Communications, 2023 Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood.
Qian Xiao +12 more
doaj +1 more source
The Immune Tolerance Network: tolerance at the crossroads [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 Immune tolerance therapies are designed to reprogramme immune cells in a highly specific fashion in order to eliminate pathogenic responses but preserve normal immune function. A concept that has tantalized immunologists for decades, tolerogenic therapies would replace current lifelong immunosuppressive regimens and their often debilitating side ...
J A, Bluestone, J, Matthews
openaire +2 more sources
Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
Frontiers in Immunology, 2021 Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies.
Isabelle Serr +8 more
doaj +1 more source
Immune Tolerance in the Oral Mucosa [PDF]
, 2021 The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms.
Sánchez Trincado López, José Luis +3 more
core +1 more source
Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity
Frontiers in Immunology, 2018 Autoimmunity represents a broad category of diseases that involve a variety of organ targets and distinct autoantigens. For patients with autoimmune diseases who fail to respond to approved disease-modifying treatments, autologous hematopoietic stem cell
Kristina M. Harris +4 more
doaj +1 more source
Towards Immune Inspired Fault Tolerance in Embedded Systems [PDF]
, 2002 The immune system is a remarkable natural system that is proving to be of great inspiration to computer scientists and engineers alike. This paper discusses the role that the immune system can play in the development of fault tolerant embedded systems ...
Timmis, Jon +3 more
core +1 more source
Role of regulatory T cells in immune tolerance [PDF]
, 2009 In this present work, we investigated the role of dendritic cells (DC) and regulatory T cells (Treg) in immune tolerance as well as their potential in the treatment of autoimmune or graft versus host (GvH) diseases.
Swee, Lee Kim
core +1 more source
Frontiers in Immunology, 2017 ObjectiveTo examine if the protective effect of parasite infection on experimental autoimmune encephalomyelitis (EAE) was due to interleukin (IL)-5, a cytokine produced by a type-2 response that induces eosinophilia.
Giang T. Tran +7 more
doaj +1 more source
Helminths and immunological tolerance [PDF]
, 2014 Current immunosuppression regimens for solid-organ transplantation have shown disappointing efficacy in the prevention of chronic allograft rejection and carry unacceptable risks including toxicity, neoplasia, and life-threatening infection.
McSorley, Henry J. +11 more
core +1 more source
Frontiers in Immunology, 2018 Despite the constant development of innovative therapeutic options for hematological malignancies, the gold-standard therapy regimen for curative treatment often includes allogeneic hematopoietic stem cell transplantation (HSCT).
Nadja Hilger +13 more
doaj +1 more source