Results 21 to 30 of about 344,792 (261)

miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes

Frontiers in Endocrinology, 2020
The important role of microRNAs as major modulators of various physiological processes, including immune regulation and homeostasis, has been increasingly recognized.
Martin G. Scherm, Martin G. Scherm, Carolin Daniel, Carolin Daniel, Carolin Daniel   +4 more
doaj   +1 more source

Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities

Frontiers in Immunology, 2021
Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity.
Isabelle Serr, Isabelle Serr, Felix Drost, Benjamin Schubert, Benjamin Schubert, Carolin Daniel, Carolin Daniel, Carolin Daniel   +7 more
doaj   +1 more source

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Frontiers in Immunology, 2019
Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells.
Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall   +11 more
doaj   +1 more source

Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells

Clinical and Developmental Immunology, 2013
Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen-(CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a preconditioning agent, followed by an
Corina Peña, David Gárate, Juan Contreras-Levicoy, Octavio Aravena, Diego Catalán, Juan C. Aguillón   +5 more
doaj   +1 more source

CD4+CD25+ T regulatory cells in renal transplantation

Frontiers in Immunology, 2022
The immune response to an allograft activates lymphocytes with the capacity to cause rejection. Activation of CD4+CD25+Foxp3+T regulatory cells (Treg) can down-regulate allograft rejection and can induce immune tolerance to the allograft. Treg represent &
Jason Cheung, Beata Zahorowska, Michael Suranyi, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Jason Diep, Stephen T. Spicer, Stephen T. Spicer, Nirupama D. Verma, Nirupama D. Verma, Suzanne J. Hodgkinson, Suzanne J. Hodgkinson, Bruce M. Hall, Bruce M. Hall, Bruce M. Hall   +15 more
doaj   +1 more source

Regulation of T Follicular Helper Cells in Islet Autoimmunity

Frontiers in Immunology, 2018
T follicular helper (TFH) cells are an integral part of humoral immunity by providing help to B cells to produce high-affinity antibodies. The TFH precursor compartment circulates in the blood and TFH cell dysregulation is implied in various autoimmune ...
Isabelle Serr, Isabelle Serr, Carolin Daniel, Carolin Daniel   +3 more
doaj   +1 more source

Chaperone-Mediated Autophagy Ablation in Pericytes Reveals New Glioblastoma Prognostic Markers and Efficient Treatment Against Tumor Progression

Frontiers in Cell and Developmental Biology, 2022
Background: The lack of knowledge of the progression mechanisms of glioblastoma (GB), the most aggressive brain tumor, contributes to the absence of successful therapeutic strategies.
María Luisa Molina, María Luisa Molina, David García-Bernal, David García-Bernal, David García-Bernal, María Dolores Salinas, María Dolores Salinas, Gonzalo Rubio, Pedro Aparicio, José M. Moraleda, José M. Moraleda, Salvador Martínez, Rut Valdor, Rut Valdor, Rut Valdor   +14 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Nature Communications, 2016
Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler, Carolin Daniel   +11 more
doaj   +1 more source

HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success

Frontiers in Immunology, 2022
RationalePrevious studies identified an interaction between HLA and oral peanut exposure. HLA-DQA1*01:02 had a protective role with the induction of Ara h 2 epitope-specific IgG4 associated with peanut consumption during the LEAP clinical trial for ...
Kanika Kanchan, Gautam Shankar, Michelle F. Huffaker, Henry T. Bahnson, Henry T. Bahnson, R Sharon Chinthrajah, Srinath Sanda, Monali Manohar, Hua Ling, Justin E. Paschall, George Du Toit, Ingo Ruczinski, Alkis Togias, Gideon Lack, Kari C. Nadeau, Stacie M. Jones, Gerald T. Nepom, Gerald T. Nepom, Rasika A. Mathias   +18 more
doaj   +1 more source