Results 31 to 40 of about 367,328 (307)

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Frontiers in Immunology, 2019
Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells.
Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall   +11 more
doaj   +1 more source

Immune Tolerance in the Oral Mucosa

, 2021
The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms.
Sánchez Trincado López, José Luis, Peláez Prestel, Héctor Fernando, Reche Gallardo, Pedro Antonio, Lafuente Duarte, María Esther   +3 more
core   +1 more source

Immune Tolerance of the Human Decidua [PDF]

Journal of Clinical Medicine, 2021
The endometrium is necessary for implantation, complete development of the placenta, and a successful pregnancy. The endometrium undergoes repeated cycles of proliferation, decidualization (differentiation), and shedding during each menstrual cycle.
Hiromi Murata, Susumu Tanaka, Hidetaka Okada   +2 more
openaire   +2 more sources

Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells

Clinical and Developmental Immunology, 2013
Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen-(CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a preconditioning agent, followed by an
Corina Peña, David Gárate, Juan Contreras-Levicoy, Octavio Aravena, Diego Catalán, Juan C. Aguillón   +5 more
doaj   +1 more source

CD4+CD25+ T regulatory cells in renal transplantation

Frontiers in Immunology, 2022
The immune response to an allograft activates lymphocytes with the capacity to cause rejection. Activation of CD4+CD25+Foxp3+T regulatory cells (Treg) can down-regulate allograft rejection and can induce immune tolerance to the allograft. Treg represent &
Jason Cheung, Beata Zahorowska, Michael Suranyi, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Jason Diep, Stephen T. Spicer, Stephen T. Spicer, Nirupama D. Verma, Nirupama D. Verma, Suzanne J. Hodgkinson, Suzanne J. Hodgkinson, Bruce M. Hall, Bruce M. Hall, Bruce M. Hall   +15 more
doaj   +1 more source

Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer [PDF]

, 2014
Copyright: © 2014 Li, Symonds, Miao, Sanderson and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Miao, T, Ping eWang, Suling Li, Tizong Miao, Sanderson, I, Tizong eMiao, Ian eSanderson, Alistair L. J. Symonds, Ping Wang, Suling eLi, Ian Sanderson, Wang, P, Li, S, Symonds, ALJ   +13 more
core   +1 more source

Determinants of successful immune tolerance induction in hemophilia A: systematic review and meta-analysis [PDF]

, 2023
Background: Immune tolerance induction (ITI) aims to eradicate anti-factor VIII (FVIII) antibodies (inhibitors) in persons with hemophilia A. However, this burdensome treatment fails in 10% to 40%.
International Genetic and clinical determinants of the Outcome of Immune Tolerance Induction (GO-ITI) study group
core  

Regulation of T Follicular Helper Cells in Islet Autoimmunity

Frontiers in Immunology, 2018
T follicular helper (TFH) cells are an integral part of humoral immunity by providing help to B cells to produce high-affinity antibodies. The TFH precursor compartment circulates in the blood and TFH cell dysregulation is implied in various autoimmune ...
Isabelle Serr, Isabelle Serr, Carolin Daniel, Carolin Daniel   +3 more
doaj   +1 more source

Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology [PDF]

, 2016
The break on immune tolerance is a common point between autoimmune diseases and the uncontrolled effector immune responses against allo-antigens in transplantation.
Sergio Quezada, Juan C. Aguillon, Aguillon, Juan C., Pino-Lagos, Diego Francisco Catalan, Lagos, Pino, Quezada, Sergio, Catalan, Diego Francisco   +7 more
core   +1 more source

Chaperone-Mediated Autophagy Ablation in Pericytes Reveals New Glioblastoma Prognostic Markers and Efficient Treatment Against Tumor Progression

Frontiers in Cell and Developmental Biology, 2022
Background: The lack of knowledge of the progression mechanisms of glioblastoma (GB), the most aggressive brain tumor, contributes to the absence of successful therapeutic strategies.
María Luisa Molina, María Luisa Molina, David García-Bernal, David García-Bernal, David García-Bernal, María Dolores Salinas, María Dolores Salinas, Gonzalo Rubio, Pedro Aparicio, José M. Moraleda, José M. Moraleda, Salvador Martínez, Rut Valdor, Rut Valdor, Rut Valdor   +14 more
doaj   +1 more source