Results 41 to 50 of about 367,328 (307)

Arginine depletion as a mechanism for the immune privilege of corneal allografts. [PDF]

, 2011
The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model.
Larkin, Daniel FP, George, Andrew J.T., Fu, Hongmei, Coe, D, Hongmei Fu, Chai, J-G, Zaher, S, David Coe, George, Andrew JT, Fu, H, Khan, A, Larkin, Daniel F.P., Jian-Guo Chai, Ingrid Müller, Kropf, P, Müller, Ingrid, Kropf, Pascale, Larkin, DFP, George, AJT, Adnan Khan, Khan, Adnan, Zaher, Sarah, Daniel F. P. Larkin, Mueller, I, Pascale Kropf, Coe, David, Sarah Zaher, Andrew J. T. George, Chai, Jian-Guo   +28 more
core   +1 more source

HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success

Frontiers in Immunology, 2022
RationalePrevious studies identified an interaction between HLA and oral peanut exposure. HLA-DQA1*01:02 had a protective role with the induction of Ara h 2 epitope-specific IgG4 associated with peanut consumption during the LEAP clinical trial for ...
Kanika Kanchan, Gautam Shankar, Michelle F. Huffaker, Henry T. Bahnson, Henry T. Bahnson, R Sharon Chinthrajah, Srinath Sanda, Monali Manohar, Hua Ling, Justin E. Paschall, George Du Toit, Ingo Ruczinski, Alkis Togias, Gideon Lack, Kari C. Nadeau, Stacie M. Jones, Gerald T. Nepom, Gerald T. Nepom, Rasika A. Mathias   +18 more
doaj   +1 more source

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]

, 2008
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun, Gudrun Hintereder, Michael P. Manns, Christen, Urs, Herrath, Matthias G. von, Holdener, Martin, Monika Bayer, Johnson, Eric F., Urs Christen, Rodrigo, Evelyn, Frank J. Gonzalez, Pfeilschifter, Josef (Prof. Dr.), Eric F. Johnson, Evelyn Rodrigo, Gonzalez, Frank J., Martin Holdener, Edith Hintermann, Hintermann, Edith, Matthias von G. Herrath, Josef Pfeilschifter, Rhode, Antje, Bayer, Monika, Manns, Michael P., Antje Rhode   +23 more
core   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Nature Communications, 2016
Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler, Carolin Daniel   +11 more
doaj   +1 more source

Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression

Frontiers in Immunology, 2022
Myeloid-derived suppressor cells (MDSCs) are myeloid precursors that exert potent immunosuppressive properties in cancer. Despite the extensive knowledge on mechanisms implicated in mobilization, recruitment, and function of MDSCs, their therapeutic ...
Iosif Papafragkos, Iosif Papafragkos, Maria Grigoriou, Louis Boon, Andreas Kloetgen, Aikaterini Hatzioannou, Panayotis Verginis, Panayotis Verginis, Panayotis Verginis, Panayotis Verginis   +9 more
doaj   +1 more source

Intrahepatic CD8+ lymphocyte trapping during tolerance induction using mushroom derived formulations: A possible role for liver in tolerance induction

, 2008
AIM: To determine the immunomodulatory effect of Shiitake (a mushroom extract), we tested its effect on liver-mediated immune regulation in a model of immune-mediated colitis. METHODS: Four groups of mice were studied. Colitis was induced by intracolonic
Hershcovici, T., Lidya Zolotarov, Shuvy, M., Mony Shuvy, Cristina Lull-Noguera, Lull-Noguera, C., Tiberiu Hershcovici, Wichers, H.J., Dan Levanon, Harry Wichers, Yaron Ilan, Ofer Danay   +11 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease

Frontiers in Immunology, 2021
Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance of tolerance in
Giada Amodio, Alessandra Mandelli, Rosalia Curto, Paola M. V. Rancoita, Angela Stabilini, Riccardo Bonfanti, Riccardo Bonfanti, Maurizio de Pellegrin, Emanuele Bosi, Emanuele Bosi, Emanuele Bosi, Clelia Di Serio, Manuela Battaglia, Silvia Gregori   +13 more
doaj   +1 more source