Results 41 to 50 of about 369,026 (262)

HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success

Frontiers in Immunology, 2022
RationalePrevious studies identified an interaction between HLA and oral peanut exposure. HLA-DQA1*01:02 had a protective role with the induction of Ara h 2 epitope-specific IgG4 associated with peanut consumption during the LEAP clinical trial for ...
Kanika Kanchan, Gautam Shankar, Michelle F. Huffaker, Henry T. Bahnson, Henry T. Bahnson, R Sharon Chinthrajah, Srinath Sanda, Monali Manohar, Hua Ling, Justin E. Paschall, George Du Toit, Ingo Ruczinski, Alkis Togias, Gideon Lack, Kari C. Nadeau, Stacie M. Jones, Gerald T. Nepom, Gerald T. Nepom, Rasika A. Mathias   +18 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression

Frontiers in Immunology, 2022
Myeloid-derived suppressor cells (MDSCs) are myeloid precursors that exert potent immunosuppressive properties in cancer. Despite the extensive knowledge on mechanisms implicated in mobilization, recruitment, and function of MDSCs, their therapeutic ...
Iosif Papafragkos, Iosif Papafragkos, Maria Grigoriou, Louis Boon, Andreas Kloetgen, Aikaterini Hatzioannou, Panayotis Verginis, Panayotis Verginis, Panayotis Verginis, Panayotis Verginis   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease

Frontiers in Immunology, 2021
Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance of tolerance in
Giada Amodio, Alessandra Mandelli, Rosalia Curto, Paola M. V. Rancoita, Angela Stabilini, Riccardo Bonfanti, Riccardo Bonfanti, Maurizio de Pellegrin, Emanuele Bosi, Emanuele Bosi, Emanuele Bosi, Clelia Di Serio, Manuela Battaglia, Silvia Gregori   +13 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies

Frontiers in Immunology, 2019
Rodent models of rheumatoid arthritis (RA) have been used over decades to study the immunopathogenesis of the disease and to explore intervention strategies.
Katina Schinnerling, Katina Schinnerling, Carlos Rosas, Lilian Soto, Lilian Soto, Ranjeny Thomas, Juan Carlos Aguillón   +6 more
doaj   +1 more source

Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications

Frontiers in Immunology, 2021
The immune system recognizes and attacks non-self antigens, making up the cornerstone of immunity activity against infection. However, during organ transplantation, the immune system also attacks transplanted organs and leads to immune rejection and ...
Jin-Yu Sun, Rui Wu, Rui Wu, Rui Wu, Jiang Xu, Hui-Ying Xue, Xiao-Jie Lu, Jiansong Ji   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source