Results 41 to 50 of about 1,952,965 (303)

Regulatory T cell proliferative potential as novel marker to investigate immune tolerance and clinical progression in Multiple Sclerosis [PDF]

, 2011
In autoimmune disorders such as Multiple Sclerosis (MS) one of the determining alteration is the breakdown of self-antigen immune-tolerance. Peripheral immune tolerance is maintained, at least in part, by Regulatory T cells (Treg).
Carbone, Fortunata
core   +1 more source

Tolerance analysis approach based on the classification of uncertainty (aleatory / epistemic) [PDF]

, 2012
Uncertainty is ubiquitous in tolerance analysis problem. This paper deals with tolerance analysis formulation, more particularly, with the uncertainty which is necessary to take into account into the foundation of this formulation.
Qureshi, A.J., LEMAIRE, Maurice, Etienne, A., DANTAN, Jean-Yves, Gayton, Nicolas, QURESHI, Ahmed Jawad, GAYTON, N., Lemaire, M., ETIENNE, Alain, Dantan, J.Y.   +9 more
core   +1 more source

Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer [PDF]

, 2014
Copyright: © 2014 Li, Symonds, Miao, Sanderson and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Miao, T, Ping eWang, Suling Li, Tizong Miao, Sanderson, I, Tizong eMiao, Ian eSanderson, Alistair L. J. Symonds, Ping Wang, Suling eLi, Ian Sanderson, Wang, P, Li, S, Symonds, ALJ   +13 more
core   +1 more source

The coevolution of virulence : tolerance in perspective [PDF]

, 2010
Coevolutionary interactions, such as those between host and parasite, predator and prey, or plant and pollinator, evolve subject to the genes of both interactors.
Colegrave, Nick, Colegrave Nick, Tom J. Little, David M Shuker, Day, Troy, Tom J Little, Graham Andrea L., Nick Colegrave, Little, Tom J., Troy Day, Shuker David M., Graham, Andrea L., Andrea L. Graham, Little Tom J., David M. Shuker, Day Troy, Shuker, David M., Andrea L Graham   +17 more
core   +2 more sources

Splenic CD8(+) T cells secrete TGF-beta 1 to exert suppression in mice with anterior chamber-associated immune deviation [PDF]

, 2009
Background CD8(+) regulatory T cells (Treg) have been considered to be involved in a model of ocular-induced tolerance, known as anterior chamber-associated immune deviation (ACAID).
Hao He, Lin, X.M., Peizeng Yang, Jiang, L.Q., Hongyan Zhou, Aize Kijlstra, Liqiong Jiang, Huang, X.K., Yang, P.Z., He, H., Zhou, H.Y., Xiaomin Lin, Xiangkun Huang, Kijlstra, A.   +13 more
core   +1 more source

Long term impact of systemic bacterial infection on the cerebral vasculature and microglia [PDF]

, 2012
Background: Systemic infection leads to generation of inflammatory mediators that result in metabolic and behavioural changes. Repeated or chronic systemic inflammation leads to a state of innate immune tolerance: a protective mechanism against over ...
Perry, V. Hugh, Püntener Ursula, Perry V, Steven G Booth, Teeling, Jessica L., Booth Steven G, V Hugh Perry, Ursula Püntener, Teeling Jessica L, Jessica L Teeling, Puentener, U., Booth, S.   +11 more
core   +3 more sources

Determinants of successful immune tolerance induction in hemophilia A: systematic review and meta-analysis [PDF]

, 2023
Background: Immune tolerance induction (ITI) aims to eradicate anti-factor VIII (FVIII) antibodies (inhibitors) in persons with hemophilia A. However, this burdensome treatment fails in 10% to 40%.
International Genetic and clinical determinants of the Outcome of Immune Tolerance Induction (GO-ITI) study group
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology [PDF]

, 2016
The break on immune tolerance is a common point between autoimmune diseases and the uncontrolled effector immune responses against allo-antigens in transplantation.
Sergio Quezada, Juan C. Aguillon, Aguillon, Juan C., Pino-Lagos, Diego Francisco Catalan, Lagos, Pino, Quezada, Sergio, Catalan, Diego Francisco   +7 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source