Results 51 to 60 of about 1,952,965 (303)

Arginine depletion as a mechanism for the immune privilege of corneal allografts. [PDF]

, 2011
The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model.
Larkin, Daniel FP, George, Andrew J.T., Fu, Hongmei, Coe, D, Hongmei Fu, Chai, J-G, Zaher, S, David Coe, George, Andrew JT, Fu, H, Khan, A, Larkin, Daniel F.P., Jian-Guo Chai, Ingrid Müller, Kropf, P, Müller, Ingrid, Kropf, Pascale, Larkin, DFP, George, AJT, Adnan Khan, Khan, Adnan, Zaher, Sarah, Daniel F. P. Larkin, Mueller, I, Pascale Kropf, Coe, David, Sarah Zaher, Andrew J. T. George, Chai, Jian-Guo   +28 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Nature Communications, 2016
Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler, Carolin Daniel   +11 more
doaj   +1 more source

Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression

Frontiers in Immunology, 2022
Myeloid-derived suppressor cells (MDSCs) are myeloid precursors that exert potent immunosuppressive properties in cancer. Despite the extensive knowledge on mechanisms implicated in mobilization, recruitment, and function of MDSCs, their therapeutic ...
Iosif Papafragkos, Iosif Papafragkos, Maria Grigoriou, Louis Boon, Andreas Kloetgen, Aikaterini Hatzioannou, Panayotis Verginis, Panayotis Verginis, Panayotis Verginis, Panayotis Verginis   +9 more
doaj   +1 more source

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]

, 2008
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun, Gudrun Hintereder, Michael P. Manns, Christen, Urs, Herrath, Matthias G. von, Holdener, Martin, Monika Bayer, Johnson, Eric F., Urs Christen, Rodrigo, Evelyn, Frank J. Gonzalez, Pfeilschifter, Josef (Prof. Dr.), Eric F. Johnson, Evelyn Rodrigo, Gonzalez, Frank J., Martin Holdener, Edith Hintermann, Hintermann, Edith, Matthias von G. Herrath, Josef Pfeilschifter, Rhode, Antje, Bayer, Monika, Manns, Michael P., Antje Rhode   +23 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease

Frontiers in Immunology, 2021
Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance of tolerance in
Giada Amodio, Alessandra Mandelli, Rosalia Curto, Paola M. V. Rancoita, Angela Stabilini, Riccardo Bonfanti, Riccardo Bonfanti, Maurizio de Pellegrin, Emanuele Bosi, Emanuele Bosi, Emanuele Bosi, Clelia Di Serio, Manuela Battaglia, Silvia Gregori   +13 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

T-cells and transplantation tolerance in Thymectomised Xenopus implanted with foreign thymus [PDF]

, 1990
This thesis investigates the expression of a T-cell differentiation antigen, (XTLA- 1), in various strains and species of Xenopus, and demonstrates the effect of early-thymectomy, (by microcautery), on XTLA-1 expression.
Varley, C.A, Varley, Claire Alison
core  

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance [PDF]

, 2010
Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses.
Cook, T, Derbyshire, Katy, Dyson, Julian, Cook, Terence, Chai, JG, Coe, D, Scott, Diane, Dumitriu, IE, Baruah, Paramita, Coe, David, Dumitriu, Ingrid E; id_orcid, Dyson, J, Baruah, P, Derbyshire, K, Simpson, Elizabeth, Botto, Marina, Addey, C, Scott, D, Addey, Caroline, Botto, M, Chai, Jian-Guo, Simpson, E   +21 more
core   +1 more source