Results 71 to 80 of about 367,328 (307)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Artificial Immune Systems: A Novel Approach to Pattern Recognition [PDF]

, 2002
This chapter introduces a new computational intelligence paradigm to perform pattern recognition, named Artificial Immune Systems (AIS). AIS take inspiration from the immune system in order to build novel computational tools to solve problems in a vast ...
Timmis, Jon, de Castro, Leandro N.
core  

A strong immune response in young adult honeybees masks their increased susceptibility to infection compared to older bees [PDF]

, 2012
Honeybees, Apis mellifera, show age-related division of labor in which young adults perform maintenance ("housekeeping") tasks inside the colony before switching to outside foraging at approximately 23 days old. Disease resistance is an important feature
Baxter, LA, James C Bull, Bull James C., Ryabov, EV, Laura A. Baxter, Baxter Laura A., Mead, A, Pell, JK, Judith K. Pell (107694), Laura A Baxter, Osborne Juliet L., Ryabov, Eugene V., Chandler, D, Prince Gill, Judith K. Pell¤b, Juliet L Osborne, Prince, G, Osborne, Juliet L., Osborne, JL, Judith K Pell, Cunjin Zhang, Prince, Gillian, Dave Chandler (107700), Zhang, C., Laura A. Baxter (107691), Ryabov, E. V., Zhang Cunjin, Dave Ch, Chandler Dave, Baxter, L. A., Juliet L. Osborne¤c, James C. Bull (107677), Pell Judith K., Ryabov Eugene V., Baxter, Laura, James Bull, Chandler, Dave, Eugene V. Ryabov (107680), Mead, A. (Andrew), Zhang, Cunjin, Eugene V Ryabov, Andrew Mead, Cunjin Zhang (107690), James C. Bull, Mead Andrew, Chandler, D., Gill Prince, Bull, James C., Prince, G., Pell, Judith K., Dave Chandler, Pell, J. K., Osborne, J. L., Juliet L. Osborne (107697), Zhang, C, Andrew Mead (107686), Mead, A., Bull, JC, Bull, J. C., Eugene V. Ryabov, Gill Prince (107683)   +60 more
core   +1 more source

Challenges in the pursuit of immune tolerance [PDF]

Immunological Reviews, 2011
Summary:  Strategies for inducing immune tolerance are fundamentally similar across a spectrum of immune‐mediated disorders, including allergic disease, autoimmunity, and rejection of allografts. In each case, the objective of establishing an immunoregulatory balance is challenged by variable upswings in effector cell populations and proinflammatory ...
Gerald T, Nepom, E William, St Clair, Laurence A, Turka   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Short-term cold exposure supports human Treg induction in vivo

Molecular Metabolism, 2019
Objective: Obesity and type-2 diabetes (T2D) are metabolic diseases that represent a critical health problem worldwide. Metabolic disease is differentially associated with fat distribution, while visceral white adipose tissue (VAT) is particularly prone ...
Maike Becker, Isabelle Serr, Victoria K. Salb, Verena B. Ott, Laura Mengel, Matthias Blüher, Benno Weigmann, Hans Hauner, Matthias H. Tschöp, Carolin Daniel   +9 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Insect capa neuropeptides impact desiccation and cold tolerance [PDF]

, 2015
This work was funded by grants from the UK Biotechnology and Biological Sciences Research Council (BB/G020620 and BB/L002647/1) (to S.-A.D., J.A.T.D., and S.T.); US Department of Agriculture/Department of Defense Deployed War Fighters Protection Grant ...
Denlinger, David L., Davies, Shireen-A., Ritchie, Michael G., Davies, Shireen-Anne, Nachman, Ronald J., Teets, Nicholas, Terhzaz, Selim, Henderson, Louise, Richie, Michael G., Teets, Nichholas M., Cabrero, Pablo, Dow, Julian A. T.   +11 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source