Results 71 to 80 of about 1,952,965 (303)

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

Nature Communications, 2019
miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel   +11 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Distribution of HLA-ABC allele groups in a cohort of Chilean rheumatoid arthritis patients and healthy individuals

Biological Research
Background Rheumatoid Arthritis (RA) is an autoimmune disease in which HLA-DRB1 alleles encoding the “Shared Epitope” (SE), located in the β-chain of class II HLA-DR molecules, constitute the main genetic risk factor. However, there is scarce information
Miqueas Jaime, Lucero Toro, Constanza Varela-Villarroel, Darly Montano-Bruno, Bárbara Pesce, Daniela Schneider, Lilian Soto, Francisca Bozán, Óscar Neira, María C. Cuéllar-Gutiérrez, Consuelo Arroyo, Guido Rivera, Eduard Palou, Diego Catalán, Jaxaira Maggi, Juan C. Aguillón   +15 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms [PDF]

, 2003
Copyright @ 2003 The Rockefeller University PressCD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved.
Maloy, Kevin, Fiona Powrie, Maloy, Kevin J., Gordon Dougan, Powrie, Fiona, Dougan, Gordon, Saunders, Nigel, Laurence Salaun, Cahill, R, Saunders, NJ, Saunders, Nigel J., Nigel J. Saunders, Salaun, L, Powrie, F, Rachel Cahill, Kevin J. Maloy, Salaun, Laurence, Maloy, KJ, Dougan, G, Cahill, Rachel   +19 more
core   +1 more source

Source data for: Hodgson et al, NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance, Communications Biology 2022

, 2022
Source data for Hodgson et al, NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance, Communications Biology 2022. Flow cytometry data, and representative images for gating strategies.
Bhandari, Aneesha, Cebrian-Serrano, Alberto, Hodgson, Rose, Kepple, Jessica D, Anzilotti, C, Bull, Katherine R, Cornall, Richard J, Davies, Benjamin, Deobagkar-Lele, Mukta, Wilcock, Martin J, Cawthorne, Eleanor, Crockford, Tanya L, Xu, Xijing   +12 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis [PDF]

, 2013
Activation of dendritic cells by different pathogens induces the secretion of proinflammatory mediators resulting in local inflammation. Importantly, innate immunity must be properly controlled, as its continuous activation leads to the development of ...
Szász, András, István Nagy (147904), Vilmos Tubak (455817), Kemény Lajos, Kondorosi, Éva, András Szász, Zoltán Hegedűs (455815), Tubak Vilmos, Lajos Kemény, Éva Kondorosi (3507242), Kata Filkor (455814), Kondorosi Éva, Nagy István, Tubák, Vilmos, Lajos Kemény (229288), Hegedűs Zoltán, Szász András, István Nagy, Kemény, Lajos, Éva Kondorosi, Nagy, István, Filkor, Katalin, Vilmos Tubak, Filkor Kata, Hegedűs, Zoltán, András Szász (455816), Kata Filkor, Zoltán Hegedűs   +27 more
core   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Self Model and the Conception of Biological Identity in Immunology [PDF]

, 2005
The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for sixty years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal ...
Pradeu, Thomas, Carosella, Edgardo,, Carosella, Edgardo, D., Carosella, Edgardo D., Thomas Pradeu, Edgardo D. Carosella   +5 more
core   +1 more source