Results 41 to 50 of about 1,946,426 (304)

T Cell Repertoire and Inflammatory Bowel Disease

Canadian Journal of Gastroenterology, 1996
The diversity of the T cell receptor repertoire is generated through rearrangement of the variable, junctional and constant region genes. Selection processes in the thymus and periphery serve to eliminate self-reacting T cells, thereby preventing ...
Kenneth Croitoru, David KH Wong, Maria E Baca-Estrada   +2 more
doaj   +1 more source

Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance.

PLoS Pathogens, 2017
The dynamics of the memory CD8 T cell receptor (TCR) repertoire upon virus re-exposure and factors governing the selection of TCR clonotypes conferring protective immunity in real life settings are poorly understood.
Mohamed S Abdel-Hakeem, Maude Boisvert, Julie Bruneau, Hugo Soudeyns, Naglaa H Shoukry   +4 more
doaj   +1 more source

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

Nature Communications, 2017
γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in ...
Martin S. Davey, C. Willcox, S. P. Joyce, K. Ladell, Sofya A Kasatskaya, J. E. McLaren, S. Hunter, Mahboob Salim, F. Mohammed, D. Price, D. Chudakov, B. Willcox   +11 more
semanticscholar   +1 more source

Individual Epitope-Specific CD8⁺ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection

Pathogens, 2023
A hallmark in chronic viral infections are exhausted antigen-specific CD8+ T cell responses and the inability of the immune system to eliminate the virus.
Sebastian Klein, Jasmin Mischke, Finn Beruldsen, Immo Prinz, Dinler A. Antunes, Markus Cornberg, Anke R. M. Kraft   +6 more
doaj   +1 more source

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

eLife, 2022
Antigen recognition through the T cell receptor (TCR) αβ heterodimer is one of the primary determinants of the adaptive immune response. Vaccines activate naïve T cells with high specificity to expand and differentiate into memory T cells.
George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi   +18 more
doaj   +1 more source

Class II MHC self-antigen presentation in human B and T lymphocytes. [PDF]

PLoS ONE, 2012
Human CD4(+) T cells process and present functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains unknown. We eluted and sequenced HLA-DR-bound self-peptides presented by CD4(
Cristina Maria Costantino, Eric Spooner, Hidde L Ploegh, David A Hafler   +3 more
doaj   +1 more source

Recall T cell responses to bluetongue virus produce a narrowing of the T cell repertoire

Veterinary Research, 2017
In most viral infections, recall T cell responses are critical for protection. The magnitude of these secondary responses can also affect the CD8 and CD4 epitope repertoire diversity.
José-Manuel Rojas, Teresa Rodríguez-Calvo, Noemí Sevilla   +2 more
doaj   +1 more source

The Course of Immune Stimulation by Photodynamic Therapy: Bridging fundamentals of photochemically-induced Immunogenic Cell Death to the Enrichment of T Cell Repertoire

Photochemistry and Photobiology, 2019
Photodynamic therapy (PDT) is a potentially immunogenic and FDA‐approved antitumor treatment modality that utilizes the spatiotemporal combination of a photosensitizer, light and oftentimes oxygen, to generate therapeutic cytotoxic molecules.
S. Nath, Girgis Obaid, T. Hasan
semanticscholar   +1 more source

Is the exquisite specificity of lymphocytes generated by thymic selection or due to evolution?

Frontiers in Immunology
We have previously argued that the antigen receptors of T and B lymphocytes evolved to be sufficiently specific to avoid massive deletion of clonotypes by negative selection.
Rob J. De Boer, Can Kesmir, Alan S. Perelson, José A. M. Borghans   +3 more
doaj   +1 more source

Ibrutinib therapy increases T cell repertoire diversity in patients with chronic lymphocytic leukemia

Journal of Immunology, 2017
The Bruton’s tyrosine kinase inhibitor ibrutinib is a highly effective, new targeted therapy for chronic lymphocytic leukemia (CLL) that thwarts leukemia cell survival, growth, and tissue homing.
Q. Yin, M. Sivina, H. Robins, E. Yusko, M. Vignali, S. O'Brien, M. Keating, A. Ferrajoli, Z. Estrov, N. Jain, W. Wierda, J. Burger   +11 more
semanticscholar   +1 more source