Results 61 to 70 of about 144,479 (301)

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Frontiers in Immunology, 2023
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections, and ...
Melissa Pille, John Avila, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Glenn Goetgeluk, Glenn Goetgeluk, Stijn De Munter, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Sarah Bonte, Joline Ingels, Joline Ingels, Laurenz De Cock, Laurenz De Cock, Eva Pascal, Eva Pascal, Lucas Deseins, Lucas Deseins, Tessa Kerre, Tessa Kerre, Tom Taghon, Tom Taghon, Georges Leclercq, Georges Leclercq, David Vermijlen, David Vermijlen, David Vermijlen, David Vermijlen, Brian Davis, Bart Vandekerckhove, Bart Vandekerckhove   +36 more
doaj   +1 more source

DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire

, 2008
The majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets.
Buchan, Sarah L., Timothy J. Kendall, Philip D. Greenberg, Michelle L. Dossett, Stuart N. Dunn, Öhlén, Claes, Rice, Jason, Dossett, Michelle L., Dossett, Michelle L, Stevenson, Freda K., Kendall, Timothy J., Sarah L. Buchan, Freda K. Stevenson, Dunn, Stuart N, Greenberg, Philip D, Dunn, Stuart N., Greenberg, Philip D., Kendall, Timothy J; id_orcid, Stevenson, Freda K, Jason Rice, Buchan, Sarah L, Claes Öhlén   +21 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8+ T Cell Subsets

Frontiers in Immunology, 2017
A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cell ...
Ling Huang, Michiel G. H. Betjes, Mariska Klepper, Anton W. Langerak, Carla C. Baan, Nicolle H. R. Litjens   +5 more
doaj   +1 more source

Emergent networks in immune system shape space [PDF]

, 2005
The development of a computational model is reported which facilitates the study of emergent principles of human immune system effector T cell clonotype repertoire and its distribution and differentiation.
Burns, John
core  

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

Defining the alloreactive T cell repertoire using high-throughput sequencing of mixed lymphocyte reaction culture. [PDF]

PLoS ONE, 2014
The cellular immune response is the most important mediator of allograft rejection and is a major barrier to transplant tolerance. Delineation of the depth and breadth of the alloreactive T cell repertoire and subsequent application of the technology to ...
Ryan O Emerson, James M Mathew, Iwona M Konieczna, Harlan S Robins, Joseph R Leventhal   +4 more
doaj   +1 more source

Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity

, 2019
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J, Ask, Eivind Heggernes, Goodridge, Jodie, Lorenz, S, Lorenz, Susanne, Goodridge, JP, Clancy, T, Malmberg, Karl-Johan, Pfefferle, A,, Sohlberg, Ebba, Sohlberg, E,, Jacobs, Benedikt Marcel, Netskar, Herman, Netskar, H, Ask, EH, Pfefferle, Aline, Clancy, Trevor, Jacobs, B   +17 more
core   +1 more source