Results 21 to 30 of about 144,479 (301)

Shaping the T cell repertoire [PDF]

The Journal of Immunology, 2005
Today immunologists are well aware of positive and negative selection of developing T cells. This was very different almost three decades ago when MHC-restricted Ag recognition by T cells represented an enormous puzzle in the absence of data on the molecular nature of Ag recognition by T cells ...
openaire   +5 more sources

Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden [PDF]

, 2011
BACKGROUND:The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden.
Ngom, Pa T, Solon Juan, Ngom Pa T, Andrew M Prentice, Morgan Gareth, Juan Solon, Prentice Andrew M, Richard Aspinall, Morgan, Gareth, Pa T Ngom, Prentice, Andrew M, Sophie E Moore, Aspinall, Richard, Gareth Morgan, Moore, Sophie E, Solon, Juan, Ngom, Pa T., Moore, Sophie E., Prentice, Andrew M., Aspinall Richard, Moore Sophie E   +20 more
core   +1 more source

T cell receptor repertoire analysis in HTLV-1-associated diseases

Frontiers in Immunology, 2022
Human T lymphotropic virus 1 (HTLV-1) is a human retrovirus identified as the causative agent in adult T-cell leukemia/lymphoma (ATL) and chronic-progressive neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP ...
Annaliese Clauze, Yoshimi Enose-Akahata, Steven Jacobson   +2 more
doaj   +1 more source

T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing

Haematologica, 2019
Alloreactivity or opportunistic infections following allogeneic stem cell transplantation are difficult to predict and contribute to post-transplantation mortality.
Cornelia S. Link-Rachner, Anne Eugster, Elke Rücker-Braun, Falk Heidenreich, Uta Oelschlägel, Andreas Dahl, Christian Klesse, Matthias Kuhn, Jan Moritz Middeke, Martin Bornhäuser, Ezio Bonifacio, Johannes Schetelig   +11 more
doaj   +1 more source

Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL.

PLoS Pathogens, 2022
Reconstitution of the T cell repertoire after allogeneic stem cell transplantation is a long and often incomplete process. As a result, reactivation of Epstein-Barr virus (EBV) is a frequent complication that may be treated by adoptive transfer of donor ...
María Fernanda Lammoglia Cobo, Julia Ritter, Regina Gary, Volkhard Seitz, Josef Mautner, Michael Aigner, Simon Völkl, Stefanie Schaffer, Stephanie Moi, Anke Seegebarth, Heiko Bruns, Wolf Rösler, Kerstin Amann, Maike Büttner-Herold, Steffen Hennig, Andreas Mackensen, Michael Hummel, Andreas Moosmann, Armin Gerbitz   +18 more
doaj   +1 more source

Single-cell RNA-seq revealing the immune features of donor liver during liver transplantation

Frontiers in Immunology, 2023
Immune cells, including T and B cells, are key factors in the success of liver transplantation. And the repertoire of T cells and B cells plays an essential function in mechanism of the immune response associated with organ transplantation.
Yi Shan, Debin Qi, Lei Zhang, Lixue Wu, Wenfang Li, Hao Liu, Tao Li, Zhiren Fu, Haili Bao, Shaohua Song   +9 more
doaj   +1 more source

Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy [PDF]

, 2013
The interaction between T-cell receptors (TCRs) and peptide epitopes is highly degenerate: a TCR is capable of interacting productively with a wide range of different peptide ligands, involving not only cross-reactivity proper (similar epitopes elicit ...
Linda Wooldridge, van den Berg, Hugo Antonius, Dockree, Tamsin, Van Den Berg, Hugo A, Berg, Hugo van den, Linda eWooldridge, Williams, Tamsin, Barbara Szomolay, Tamsin eWlliams, Tamsin Williams, Szomolay, Barbara, Hugo Antonius Van Den Berg, Barbara eSzomolay, Wooldridge, Linda   +13 more
core   +1 more source

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Cell Reports, 2019
Summary: Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research ...
Caren Ramien, Erik C. Yusko, Jan Broder Engler, Stefanie Gamradt, Kostas Patas, Nils Schweingruber, Anne Willing, Sina Cathérine Rosenkranz, Anke Diemert, Anja Harrison, Marissa Vignali, Catherine Sanders, Harlan S. Robins, Eva Tolosa, Christoph Heesen, Petra C. Arck, Alexander Scheffold, Kenneth Chan, Ryan O. Emerson, Manuel A. Friese, Stefan M. Gold   +20 more
doaj   +1 more source

T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma

Journal for ImmunoTherapy of Cancer, 2020
Background Malignant pleural mesothelioma (MPM) is a highly lethal malignancy in need for new treatment options. Although immunotherapies have been shown to boost a tumor-specific immune response, not all patients respond and prognostic biomarkers are ...
Niek de Vries, Joachim G J V Aerts, Paul L Klarenbeek, Heleen Vroman, Giulia Balzaretti, Robert A Belderbos, Menno van Nimwegen, Koen Bezemer, Robin Cornelissen, Ilse T G Niewold, Barbera D van Schaik, Antione H van Kampen, Rudi W Hendriks   +12 more
doaj   +1 more source

T Cell Repertoires and Competitive Exclusion

Journal of Theoretical Biology, 1994
Self-renewal is generally thought to play a major role in the maintenance of the T-cell repertoire. Here we develop a set of mathematical models for T-cell activation by peptides on antigen presenting cells (APCs). We show that competition between T cells is inherent to the processes involved in T cells binding APCs.
Boer, R.J. de, Perelson, A.S.
openaire   +3 more sources