Results 21 to 30 of about 1,946,426 (304)
Frontiers in Immunology, 2021 Temporal analysis of the T cell receptor (TCR) repertoire has been used to monitor treatment-induced changes in antigen-specific T cells in patients with cancer.
Mikiya Tsunoda +7 more
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The T‐cell receptor repertoire of regulatory T cells [PDF]
Immunology, 2008 SummaryThe CD4+ CD25+ regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects us from a variety of autoimmune diseases.
Rafal, Pacholczyk, Joanna, Kern
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Monitoring the T-cell receptor repertoire at single-clone resolution. [PDF]
PLoS ONE, 2006 The adaptive immune system recognizes billions of unique antigens using highly variable T-cell receptors. The alphabeta T-cell receptor repertoire includes an estimated 10(6) different rearranged beta chains per individual.
Hendrik P J Bonarius +6 more
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Specific T-cell Activation in an Unspecific T-cell Repertoire [PDF]
Science Progress, 2011 T-cells are a vital type of white blood cell that circulate around our bodies, scanning for cellular abnormalities and infections. They recognise disease-associated antigens via a surface receptor called the T-cell antigen receptor (TCR). If there were a specific TCR for every single antigen, no mammal could possibly contain all the T-cells it needs ...
Berg, Hugo van den +2 more
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Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis
Frontiers in Immunology, 2022 CD8+ T cells are the key effector cells that contribute to the antitumor immune response. They comprise various T-cell clones with diverse antigen-specific T-cell receptors (TCRs).
Hiroyasu Aoki +4 more
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T-cell repertoire analysis and metrics of diversity and clonality.
Current Opinion in Biotechnology, 2020 The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated the understanding of the complexity of immune repertoire dynamics combined to transcriptomics.
Johanna Chiffelle +5 more
semanticscholar +1 more source
Shaping the T cell repertoire [PDF]
The Journal of Immunology, 2005 Today immunologists are well aware of positive and negative selection of developing T cells. This was very different almost three decades ago when MHC-restricted Ag recognition by T cells represented an enormous puzzle in the absence of data on the molecular nature of Ag recognition by T cells ...
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Positive and negative selection of the T cell repertoire: what thymocytes see and don't see
Nature reviews. Immunology, 2014 The fate of developing T cells is specified by the interaction of their antigen receptors with self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs).
Ludger Klein +3 more
semanticscholar +1 more source
T cell receptor repertoire analysis in HTLV-1-associated diseases
Frontiers in Immunology, 2022 Human T lymphotropic virus 1 (HTLV-1) is a human retrovirus identified as the causative agent in adult T-cell leukemia/lymphoma (ATL) and chronic-progressive neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP ...
Annaliese Clauze +2 more
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Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire
Journal of Experimental Medicine, 2020 The naive polyclonal CD4 T cell repertoire can differentiate into multiple lineages during acute viral infection, with some clones exhibiting a preferred lineage choice, as revealed by scRNA-seq and scTCR-seq.
Achia Khatun +11 more
semanticscholar +1 more source