Results 11 to 20 of about 144,479 (301)
The Shaping of the T Cell Repertoire [PDF]
Immunity, 2001 By combining a TCRbeta transgene with a TCRalpha minilocus comprised of a single V and two J gene segments, we engineered a mouse line exhibiting ample but focused TCR diversity, restricted to CDR3alpha. Using single-cell PCR and high-throughput sequencing, we have exploited this system to scrutinize T cell repertoire selection and evolution.
Correia-Neves, Margarida +3 more
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SELECTION OF THE T CELL REPERTOIRE
Annual Review of Immunology, 1999 ▪ Abstract Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level.
Sebzda, E +5 more
openaire +4 more sources
Monitoring the T-cell receptor repertoire at single-clone resolution. [PDF]
PLoS ONE, 2006 The adaptive immune system recognizes billions of unique antigens using highly variable T-cell receptors. The alphabeta T-cell receptor repertoire includes an estimated 10(6) different rearranged beta chains per individual.
Hendrik P J Bonarius +6 more
doaj +2 more sources
Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment [PDF]
Frontiers in Immunology, 2021 ObjectiveIn people living with HIV (PLHIV), we sought to test the hypothesis that long term anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional relationship of residual repertoire abnormalities to persistent ...
Carolin T. Turner +13 more
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T Cell Repertoire and Inflammatory Bowel Disease [PDF]
Canadian Journal of Gastroenterology, 1996 The diversity of the T cell receptor repertoire is generated through rearrangement of the variable, junctional and constant region genes. Selection processes in the thymus and periphery serve to eliminate self-reacting T cells, thereby preventing ...
Kenneth Croitoru +2 more
doaj +2 more sources
T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder
Frontiers in Immunology, 2018 While a link between inflammation and the development of neuropsychiatric disorders, including major depressive disorder (MDD) is supported by a growing body of evidence, little is known about the contribution of aberrant adaptive immunity in this ...
Kostas Patas +18 more
doaj +2 more sources
Frontiers in Immunology, 2021 Temporal analysis of the T cell receptor (TCR) repertoire has been used to monitor treatment-induced changes in antigen-specific T cells in patients with cancer.
Mikiya Tsunoda +7 more
doaj +1 more source
The T‐cell receptor repertoire of regulatory T cells [PDF]
Immunology, 2008 SummaryThe CD4+ CD25+ regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects us from a variety of autoimmune diseases.
Rafal, Pacholczyk, Joanna, Kern
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Specific T-cell Activation in an Unspecific T-cell Repertoire [PDF]
Science Progress, 2011 T-cells are a vital type of white blood cell that circulate around our bodies, scanning for cellular abnormalities and infections. They recognise disease-associated antigens via a surface receptor called the T-cell antigen receptor (TCR). If there were a specific TCR for every single antigen, no mammal could possibly contain all the T-cells it needs ...
Berg, Hugo van den +2 more
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Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis
Frontiers in Immunology, 2022 CD8+ T cells are the key effector cells that contribute to the antitumor immune response. They comprise various T-cell clones with diverse antigen-specific T-cell receptors (TCRs).
Hiroyasu Aoki +4 more
doaj +1 more source