Results 11 to 20 of about 1,946,426 (304)

Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach

Philosophical Transactions of the Royal Society B: Biological Sciences, 2015
A highly diverse T-cell receptor (TCR) repertoire is a fundamental property of an effective immune system, and is associated with efficient control of viral infections and other pathogens. However, direct measurement of total TCR diversity is impossible.
Becca Asquith, Charles Bangham, Daniel J. Laydon   +2 more
exaly   +2 more sources

T‐cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications

Cancer Communications, 2020
T cells, which are involved in adaptive immunity, are essential in the elimination of tumor cells. Mature T cells can specifically recognize the antigen on the major histocompatibility complex (MHC) molecule through T‐cell receptors (TCR).
Na Li, Jiani Yuan, Wenjia Tian, Lin Meng, Yongyu Liu   +4 more
doaj   +2 more sources

Premature Infants Have Normal Maturation of the T Cell Receptor Repertoire at Term

Frontiers in Immunology, 2022
Premature infants are known to have immature immune systems compared to term infants; however, the impacts of ex utero immune development are not well characterized.
Sarah U. Morton, Sarah U. Morton, Maureen Schnur, Rylee Kerper, Vanessa Young, Amy E. O’Connell, Amy E. O’Connell, Amy E. O’Connell   +7 more
doaj   +1 more source

Perturbations of the T-cell immune repertoire in kidney transplant rejection

Frontiers in Immunology, 2022
In this cross-sectional and longitudinal analysis of mapping the T-cell repertoire in kidney transplant recipients, we have investigated and validated T-cell clonality, immune repertoire chronology at rejection, and contemporaneous allograft biopsy ...
Tara K. Sigdel, Paul A. Fields, Juliane Liberto, Izabella Damm, Maggie Kerwin, Jill Hood, Parhom Towfighi, Marina Sirota, Harlan S. Robins, Minnie M. Sarwal   +9 more
doaj   +1 more source

Comparative Study of Repertoire Classification Methods Reveals Data Efficiency of k-mer Feature Extraction

Frontiers in Immunology, 2022
The repertoire of T cell receptors encodes various types of immunological information. Machine learning is indispensable for decoding such information from repertoire datasets measured by next-generation sequencing (NGS).
Yotaro Katayama, Tetsuya J. Kobayashi
doaj   +1 more source

Maintenance of the human memory T cell repertoire by subset and tissue site

Genome Medicine, 2021
Background Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that disseminate as circulating effector-
Michelle Miron, Wenzhao Meng, Aaron M. Rosenfeld, S. Dvorkin, Maya Meimei Li Poon, Nora Lam, Brahma V. Kumar, Y. Louzoun, E. L. Luning Prak, D. Farber   +9 more
semanticscholar   +1 more source

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Frontiers in Immunology, 2020
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the ...
Meriem Attaf, Meriem Attaf, Julia Roider, Julia Roider, Julia Roider, Julia Roider, Amna Malik, Cristina Rius Rafael, Cristina Rius Rafael, Garry Dolton, Garry Dolton, Andrew J. Predergast, Andrew J. Predergast, Andrew J. Predergast, Alasdair Leslie, Alasdair Leslie, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Henrik N. Kløverpris, Henrik N. Kløverpris, Andrew K. Sewell, Andrew K. Sewell, Philip J. Goulder, Philip J. Goulder   +26 more
doaj   +1 more source

Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment

Frontiers in Immunology, 2021
ObjectiveIn people living with HIV (PLHIV), we sought to test the hypothesis that long term anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional relationship of residual repertoire abnormalities to persistent ...
Carolin T. Turner, James Brown, James Brown, Emily Shaw, Imran Uddin, Evdokia Tsaliki, Jennifer K. Roe, Gabriele Pollara, Yuxin Sun, James M. Heather, Marc Lipman, Marc Lipman, Benny Chain, Mahdad Noursadeghi   +13 more
doaj   +1 more source

A cell atlas of human thymic development defines T cell repertoire formation

Science, 2020
Thymus development, cell by cell The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection.
Jong-Eun Park, R. Botting, C. Conde, Dorin-Mirel Popescu, M. Lavaert, D. Kunz, Issac Goh, E. Stephenson, Roberta Ragazzini, Elizabeth Tuck, A. Wilbrey-Clark, Kenny Roberts, Veronika R. Kedlian, J. Ferdinand, Xiao-Ling He, S. Webb, Daniel Maunder, N. Vandamme, K. Mahbubani, K. Polański, L. Mamanova, L. Bolt, D. Crossland, F. de Rita, A. Fuller, A. Filby, G. Reynolds, D. Dixon, K. Saeb-Parsy, S. Lisgo, D. Henderson, R. Vento-Tormo, O. Bayraktar, R. Barker, K. Meyer, Y. Saeys, P. Bonfanti, S. Behjati, M. Clatworthy, T. Taghon, M. Haniffa, S. Teichmann   +41 more
semanticscholar   +1 more source

The Shaping of the T Cell Repertoire [PDF]

Immunity, 2001
By combining a TCRbeta transgene with a TCRalpha minilocus comprised of a single V and two J gene segments, we engineered a mouse line exhibiting ample but focused TCR diversity, restricted to CDR3alpha. Using single-cell PCR and high-throughput sequencing, we have exploited this system to scrutinize T cell repertoire selection and evolution.
Correia-Neves, Margarida, Waltzinger, Caroline, Mathis, Diane, Benoist, Christophe   +3 more
openaire   +2 more sources