Results 1 to 10 of about 106,197 (158)

The structural basis of T-cell receptor (TCR) activation: An enduring enigma. [PDF]

J Biol Chem, 2020
T cells are critical for protective immune responses to pathogens and tumors. The T-cell receptor (TCR)-CD3 complex is composed of a diverse αβ TCR heterodimer noncovalently associated with the invariant CD3 dimers CD3ϵγ, CD3ϵδ, and CD3ζζ. The TCR mediates recognition of antigenic peptides bound to MHC molecules (pMHC), whereas the CD3 molecules ...
Mariuzza RA, Agnihotri P, Orban J.
europepmc   +4 more sources

T cell receptor (TCR) signaling in health and disease. [PDF]

Signal Transduct Target Ther, 2021
AbstractInteraction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors.
Shah K, Al-Haidari A, Sun J, Kazi JU.
europepmc   +5 more sources

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros [PDF]

Journal of Experimental Medicine, 1999
T cell differentiation relies on pre–T cell receptor (TCR) and TCR signaling events that take place at successive steps of the pathway. Here, we show that two of these T cell differentiation checkpoints are regulated by Ikaros. In the absence of Ikaros, double negative thymocytes can differentiate to the double positive stage without expression of a ...
Susan Winandy, Katia Georgopoulos, Li Wu   +2 more
exaly   +4 more sources

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma

Signal Transduction and Targeted Therapy
Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma (HCC) are urgently needed. The common cytokine receptor γ chain (γc) family cytokines such as IL-2, IL-7, IL-15 and IL-21 play fundamental roles in T cell ...
Wei Zhu, Zhiming Zhang, Jinzhang Chen, Xiaolan Chen, Lei Huang, Xiaoyong Zhang, Xuan Huang, Na Ma, Weikang Xu, Xuan Yi, Xinyu Lu, Xin Fu, Siwei Li, Guoheng Mo, Yiyue Wang, Guosheng Yuan, Mengya Zang, Qi Li, Xiaotao Jiang, Yajing He, Sha Wu, Yukai He, Yongyin Li, Jinlin Hou   +23 more
doaj   +4 more sources

Benchmarking of T cell receptor-epitope predictors with ePytope-TCR

Cell Genomics
Abstract Understanding the recognition of disease-derived epitopes through T-cell receptors (TCRs) has the potential to serve as a stepping stone for the development of efficient immunotherapies and vaccines. While a plethora of sequence-based prediction methods for TCR-epitope binding exists, their available pre-trained models have not
Felix Drost, Kilian Schöber, Benjamin Schubert   +2 more
exaly   +3 more sources

TCR-T immunotherapy for the treatment of solid tumor: current status, challenges and future prospects [PDF]

Zhongguo aizheng zazhi, 2023
Engineered T cell receptor-T cell (TCR-T) therapy and chimeric antigen receptor-T cell (CAR-T) therapy are currently the two most effective ways of adoptive T cell therapy.
Weitao ZHENG, Hanluo LI, Kanghong HU
doaj   +2 more sources

The role of endocytic trafficking in antigen T cell receptor activation

Biomedical Journal, 2022
Antigen T cell receptors (TCR) recognize antigenic peptides displayed by the major histocompatibility complex (pMHC) and play a critical role in T cell activation.
Irini Evnouchidou, Vivien Caillens, Despoina Koumantou, Loredana Saveanu   +3 more
doaj   +1 more source

TCR engineered T cells for solid tumor immunotherapy

Experimental Hematology & Oncology, 2022
T cell immunotherapy remains an attractive approach for cancer immunotherapy. T cell immunotherapy mainly employs chimeric antigen receptor (CAR)- and T cell receptor (TCR)-engineered T cells.
Yikai Zhang, Zhipeng Liu, Wei Wei, Yangqiu Li   +3 more
doaj   +1 more source

Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition. [PDF]

PLoS ONE, 2015
T cells are crucial players in cell-mediated immunity. The specificity of their receptor, the T cell receptor (TCR), is central for the immune system to distinguish foreign from host antigens.
Karin E J Rödström, Paulina Regenthal, Karin Lindkvist-Petersson   +2 more
doaj   +1 more source

Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges

Biomarker Research, 2023
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects.
Zhi Pang, Man-man Lu, Yu Zhang, Yuan Gao, Jin-jin Bai, Jian-ying Gu, Lu Xie, Wei-zhong Wu   +7 more
doaj   +1 more source