Results 11 to 20 of about 118,951 (307)

mRNA-Based Anti-TCR CDR3 Tumour Vaccine for T-Cell Lymphoma

Pharmaceutics, 2021
Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production of individualised vaccines conferring, T-cell immunity against ...
Marina Tusup, Severin Läuchli, Natalia Teresa Jarzebska, Lars E. French, Yun-Tsan Chang, Maya Vonow-Eisenring, Andreas Su, Thomas M. Kündig, Emmanuella Guenova, Steve Pascolo   +9 more
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Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells [PDF]

Cellular & Molecular Immunology, 2020
T cells react to foreign or self-antigens through T cell receptor (TCR) signaling. Several decades of research have delineated the mechanism of TCR signal transduction and its impact on T cell performance. This knowledge provides the foundation for chimeric antigen receptor T cell (CAR-T cell) technology, by which T cells are redirected in a major ...
Ling Wu, Qianru Wei, Joanna Brzostek, Nicholas R. J. Gascoigne   +3 more
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Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy [PDF]

, 2013
The interaction between T-cell receptors (TCRs) and peptide epitopes is highly degenerate: a TCR is capable of interacting productively with a wide range of different peptide ligands, involving not only cross-reactivity proper (similar epitopes elicit ...
Linda Wooldridge, van den Berg, Hugo Antonius, Dockree, Tamsin, Van Den Berg, Hugo A, Berg, Hugo van den, Linda eWooldridge, Williams, Tamsin, Barbara Szomolay, Tamsin eWlliams, Tamsin Williams, Szomolay, Barbara, Hugo Antonius Van Den Berg, Barbara eSzomolay, Wooldridge, Linda   +13 more
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T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies

Nature Communications, 2022
Healthy T cells are polyclonal, while malignant T cells are developing via clonal expansion. Here authors show that T cell tumours could be eradicated by chimeric antigen receptor T cells targeting the T cell receptor (TCR) β-chain that is specific to ...
Fanlin Li, Huihui Zhang, Wanting Wang, Puyuan Yang, Yue Huang, Junshi Zhang, Yaping Yan, Yuan Wang, Xizhong Ding, Jie Liang, Xinyue Qi, Min Li, Ping Han, Xiaoqing Zhang, Xin Wang, Jiang Cao, Yang-Xin Fu, Xuanming Yang   +17 more
doaj   +1 more source

Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects

Frontiers in Immunology, 2022
To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T).
Paul Shafer, Paul Shafer, Paul Shafer, Lauren M. Kelly, Lauren M. Kelly, Lauren M. Kelly, Valentina Hoyos, Valentina Hoyos   +7 more
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The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
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Novel chimeric antigen receptor T cells based on T-cell receptor-like antibodies

Blood Science, 2019
. The need for novel therapeutics against human cancers such as leukemias and solid tumors is well recognized. Human T cells are poised to make a fundamental change in the therapeutic approach. T-cell interaction with a tumor cell is a critical event and
Qi Zhao
doaj   +1 more source

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase [PDF]

, 2001
After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. The two latter proteins
Magnan, A, Anne Gillet, Arrieumerlou, C, Antoine Magnan, Boyer, C, Malissen, Bernard, Vincenzo Di Bartolo, Mireille Richelme, Marie Malissen, Lin, YL, Gillet, A., Roure, A, Mura, A. M., Boyer, C., Malissen, B, Arrieumerlou, C., Malissen, M., Malissen, M, Roure, A., Richelme, M, Acuto, O, Lin, Y. L., Bernard Malissen, Claude Boyer, Malissen, B., Di Bartolo, V, Cécile Arrieumerlou, Yea-Lih Lin, Agnès Roure, Oreste Acuto, Mura, AM, Acuto, O., Richelme, M., Acuto, Oreste, Di Bartolo, V., Anne-Marie Mura, Gillet, A, Boyer, Claudine, Magnan, A.   +38 more
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Engineered T Cell Therapy for Cancer in the Clinic

Frontiers in Immunology, 2019
T cells play a key role in cell-mediated immunity, and strategies to genetically modify T cells, including chimeric antigen receptor (CAR) T cell therapy and T cell receptor (TCR) T cell therapy, have achieved substantial advances in the treatment of ...
Lijun Zhao, Yu J. Cao
doaj   +1 more source

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells [PDF]

Proceedings of the National Academy of Sciences, 2005
During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive search for such a function yielded a very limited and specific result.
Bozidar, Purtic, Lisa A, Pitcher, Nicolai S C, van Oers, Christoph, Wülfing   +3 more
openaire   +2 more sources