Results 21 to 30 of about 118,951 (307)

Cellular-level versus receptor-level response threshold hierarchies in T-Cell activation [PDF]

, 2013
Peptide-MHC (pMHC) ligand engagement by T-cell receptors (TCRs) elicits a variety of cellular responses, some of which require substantially more TCR-mediated stimulation than others.
Andrew Kelvin Sewell, van den Berg, Hugo A., Kelly Miners, Bruno eLaugel, Sian eLlewellyn-Lacey, David A Price, Linda eWooldridge, Price, David A, Laugel, Bruno, Price, D. A., Kristin eLadell, Mathew Clement, David K Cole, Sewell, Andrew K, Cole, David K., van den Berg, Hugo A, Kelly eMiners, Emma eGostick, David A. Price, Llewellyn-Lacey, Sian, Linda Wooldridge, John S. Bridgeman, Hugo A. van den Berg, Gostick, Emma, Clement, Mathew, Berg, Hugo van den, Sian Llewellyn-Lacey, David K. Cole, Cole, David K, Bruno Laugel, John Stephen Bridgeman, Kristin Ladell, Emma Gostick, Sewell, Andrew K., Ladell, Kristin, Miners, Kelly, Bridgeman, John S., Price, David, Hugo Antonius van den Berg, Andrew K. Sewell, Bridgeman, John S, Cole, David, Wooldridge, Linda, Wooldridge, L., Mathew eClement   +44 more
core   +1 more source

Studies on the affinity control of T cell development [PDF]

, 2004
Defined interactions between thymocytes and thymic antigen presenting cells ensure that each T cell found in an individual is both self-restricted and self-tolerant.
Naeher, Dieter
core   +1 more source

Studies of suppression using monoclonal regulatory T cells and the importance of co-receptor Lck coupling ratios for negative selection [PDF]

, 2015
Normal physiology is not given without immunological tolerance. Depending on the origin of induction, tolerance can be divided into central and peripheral tolerance.
Gubser, Céline
core   +1 more source

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

Cell Reports, 2020
Summary: Efficient Ca2+ flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs).
Adrian E. Morelli, Tina L. Sumpter, Darling M. Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Jr., Adriana T. Larregina   +12 more
doaj   +1 more source

Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy

Frontiers in Immunology, 2023
IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire ...
Ping Zheng, Ping Zheng, Ning Zhang, Dabin Ren, Cong Yu, Bin Zhao, Qingke Bai, Yisong Zhang, Wanju Sun   +8 more
doaj   +1 more source

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses [PDF]

, 2007
The molecular mechanisms whereby the CD45 tyrosine phosphatase (PTPase) regulates T cell receptor (TCR) signaling responses remain to be elucidated. To investigate this question, we have reconstituted CD45 (encoded by Ptprc)-deficient mice, which display
Cooper, Joanne C, Alexander, Denis R, Cassady-Cain, Robin L., Salmond, Robert J., Tandon, Panna, Roche-Molina, Marta, Carret, Céline K., Holmes, Nick, McNeill, Louise, Cassady-Cain, Robin, Cooper, Joanne C., Alexander, Denis R., Carret, Celine K   +12 more
core   +1 more source

CD81 interacts with the T cell receptor to suppress signaling.

PLoS ONE, 2012
CD81 (TAPA-1) is a ubiquitously expressed tetraspanin protein identified as a component of the B lymphocyte receptor (BCR) and as a receptor for the Hepatitis C Virus. In an effort to identify trans-membrane proteins that interact with the T-cell antigen
Safak Isil Cevik, Nazli Keskin, Serkan Belkaya, Meral Ilcim Ozlu, Emre Deniz, Uygar Halis Tazebay, Batu Erman   +6 more
doaj   +1 more source

Diagnostic role of tests for T cell receptor (TCR) genes [PDF]

Journal of Clinical Pathology, 2003
Rapid advances in molecular biological techniques have made it possible to study disease pathogenesis at a genomic level. T cell receptor (TCR) gene rearrangement is an important event in T cell ontogeny that enables T cells to recognise antigens specifically, and any dysregulation in this complex yet highly regulated process may result in disease ...
E, Hodges, M T, Krishna, C, Pickard, J L, Smith   +3 more
openaire   +2 more sources

T-Cell activation: a queuing theory analysis at low agonist density [PDF]

, 2006
We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J.R., Burroughs, N.J., Burroughs, Nigel John, Wedagedera, J. R.   +3 more
core   +1 more source

TCR triggering by pMHC ligands tethered on surfaces via poly(ethylene glycol) depends on polymer length. [PDF]

PLoS ONE, 2014
Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC).
Zhengyu Ma, David N LeBard, Sharon M Loverde, Kim A Sharp, Michael L Klein, Dennis E Discher, Terri H Finkel   +6 more
doaj   +1 more source