Results 31 to 40 of about 118,951 (307)

Analysis of the paired TCR α- and β-chains of single human T cells. [PDF]

, 2012
Analysis of the paired i.e. matching TCR α- and β-chain rearrangements of single human T cells is required for a precise investigation of clonal diversity, tissue distribution and specificity of protective and pathologic T-cell mediated immune responses.
Dornmair, K., Besgen, P., Held, K., Bhonsle, L., Vollmer, Sigrid, Song-Min Kim, Jens Nickel, Anna Backes, Held, Kathrin, Vollmer, S., Joerg C Prinz, Backes Anna, Backes, A., Backes, Anna, Bhonsle, Latika, Kim Song-Min, Nickel, Jens, Sigrid Vollmer, Nickel, J., Kim, Song-Min, Klaus Dornmair, Dornmair, Klaus, Kim, S., Besgen Petra, Petra Besgen, Vollmer Sigrid, Prinz, Joerg C., Prinz Joerg C., Latika Bhonsle, Bhonsle Latika, Besgen, Petra, Held Kathrin, Prinz, J., Kathrin Held, Nickel Jens, Dornmair Klaus   +35 more
core   +1 more source

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity [PDF]

The Journal of Experimental Medicine, 1998
Recent data indicate that the cell surface glycoprotein CD5 functions as a negative regulator of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of CD5 surface expression during normal thymocyte ontogeny and in mice with developmental and/or signal transduction defects.
H S, Azzam, A, Grinberg, K, Lui, H, Shen, E W, Shores, P E, Love   +5 more
openaire   +2 more sources

Orthotopic T-Cell Receptor Replacement—An “Enabler” for TCR-Based Therapies [PDF]

Cells, 2020
Natural adaptive immunity co-evolved with pathogens over millions of years, and adoptive transfer of non-engineered T cells to fight infections or cancer so far exhibits an exceptionally safe and functional therapeutic profile in clinical trials. However, the personalized nature of therapies using virus-specific T cells, donor lymphocyte infusion, or ...
Kilian Schober, Thomas R. Müller, Dirk H. Busch   +2 more
openaire   +3 more sources

Regional and global changes in TCR [alpha][beta] T cell repertoires in the gut are dependent upon the complexity of the enteric microflora [PDF]

, 2010
The repertoire of gut associated T cells is shaped by exposure to microbes, including the natural enteric microflora. Previous studies compared the repertoire of gut associated T cell populations in germ free (GF) and conventional mammals often focussing
Beal, R.K., Smith, A.L., Tom Humphrey, Friedman, A., Friedman, A, Beal, RK, Bailey, M, Adrian L. Smith, Humphrey, T., Claire Powers, Wu, X, Bailey, M., William N. Mwangi, Mwangi, WN, Smith, Adrian, Watson, M, Xikun Wu, Mwangi, W.N., Richard K. Beal, Michael Watson, Humphrey, TJ, Wu, X., Humphrey, T, Watson, Mick, Smith, AL, Aharon Friedman, Powers, C, Powers, C., Michael Bailey   +28 more
core   +1 more source

The integration of signalling and the spatial organization of the T cell synapse

Frontiers in Immunology, 2012
Engagement of the T cell antigen receptor (TCR) triggers signalling pathways that lead to T cell selection, differentiation and clonal expansion. Superimposed onto the biochemical network is a spatial organization that describes individual receptor ...
Jeremie eRossy, David J Williamson, Carola eBenzing, Katharina eGaus   +3 more
doaj   +1 more source

Crystallization of a Deglycosylated T Cell Receptor (TCR) Complexed with an Anti-TCR Fab Fragment [PDF]

Journal of Biological Chemistry, 1996
A strategy to overexpress T cell receptors (TCRs) in Lec3.2.8.1 cells has been developed using the "Velcro" leucine zipper sequence to facilitate alpha-beta pairing. Upon secretion in culture media, the VSV-8-specific/H2-Kb-restricted N15 TCR could be readily immunopurified using the anti-leucine zipper monoclonal antibody 2H11, with a yield of 5-10 mg/
J, Liu, A G, Tse, H C, Chang, J h, Liu, J, Wang, R E, Hussey, Y, Chishti, B, Rheinhold, R, Spoerl, S G, Nathenson, J C, Sacchettini, E L, Reinherz   +11 more
openaire   +2 more sources

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E., Heufelder, Armin E., Scriba, Peter C.   +2 more
core   +1 more source

TCR-T Immunotherapy: The Challenges and Solutions

Frontiers in Oncology, 2022
T cell receptor-engineered T cell (TCR-T) therapy is free from the limit of surface antigen expression of the target cells, which is a potential cellular immunotherapy for cancer treatment.
Yating Liu, Yating Liu, Xin Yan, Fan Zhang, Xiaoxia Zhang, Futian Tang, Zhijian Han, Yumin Li   +7 more
doaj   +1 more source

Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells [PDF]

, 2000
Copyright @ 2000 The Rockefeller University Press. This article is shared under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons ...
Sjögren, HO, Paulsson, KM, Anette Sundstedt, Xu, X., Chen, S, Xiufeng Xu, Chen, Shangwu, Sundstedt, Anette, Karlsson, Stefan, Hans-Olov Sjögren, Karlsson, S, Li, Suling, Paulsson, Kajsa, Wang, P, Kajsa M. Paulsson, Sjögren, Hans Olov, Suling Li, Sundstedt, A, Stefan Karlsson, Xu, X, Anderson, P, Ping Wang, Wang, Ping, Shangwu Chen, Per Anderson, andersson, Per   +25 more
core   +1 more source

The Quest for the Best: How TCR Affinity, Avidity, and Functional Avidity Affect TCR-Engineered T-Cell Antitumor Responses

Cells, 2020
Over the past decades, adoptive transfer of T cells has revolutionized cancer immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked important milestones in developing more precise and personalized cancer immunotherapies ...
Diana Campillo-Davo, Donovan Flumens, Eva Lion   +2 more
doaj   +1 more source