Results 41 to 50 of about 118,951 (307)

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules [PDF]

, 1992
Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and , is still poorly understood.
Wegener, Anne-Marie K., Bernard Malissen, Malissen, Bernard, Frederle Luton, Brocker, Thomas, Frédéric Luton, François Letourneur, Frant :is Letourneur, Letourneur, François, Anne-marie K. Wegener, Thomas Brocker, Letourneur, F., Arnd Hoeveler, Thomas Broeker, Brocker, T., Hoeveler, Arnd, Wegener, Am, Hoeveler, A., Luton, Frédéric, Luton, F.   +19 more
core   +1 more source

The RhoA transcriptional program in pre-T cells [PDF]

, 2007
The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors.
Lightfoot, K., Cantrell, D., Miller, M., Lahesmaa, R., Clarke, R., Mullin, M.   +5 more
core   +1 more source

The CD3-zeta chimeric antigen receptor overcomes TCR Hypo-responsiveness of human terminal late-stage T cells. [PDF]

PLoS ONE, 2012
Adoptive therapy of malignant diseases with tumor-specific cytotoxic T cells showed remarkable efficacy in recent trials. Repetitive T cell receptor (TCR) engagement of target antigen, however, inevitably ends up in hypo-responsive cells with terminally ...
Gunter Rappl, Tobias Riet, Sabine Awerkiew, Annette Schmidt, Andreas A Hombach, Herbert Pfister, Hinrich Abken   +6 more
doaj   +1 more source

MHC‐restricted T cell receptor signaling is required for αβ TCR replacement of the pre T cell receptor [PDF]

European Journal of Immunology, 2008
AbstractA developmental block is imposed on CD25+CD44– thymocytes at the β‐selection checkpoint in the absence of the pre T cell receptor (preTCR) α‐chain, pTα. Early surface expression of a transgenic αβ TCR has been shown to partially circumvent this block, such that thymocytes progress to the CD4+CD8+ double‐positive stage.
Croxford, Andrew L, Akilli-Ozturk, Ozlem, Rieux-Laucat, Frederic, Förster, Irmgard, Waisman, Ari, Buch, Thorsten   +5 more
openaire   +3 more sources

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells [PDF]

, 2010
The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the onset of proliferation and ...
Finlay, David, Doreen Cantrell, Macintyre, Andrew, Carmen Feijoo-carnero, Clarke, Rosemary, David Finlay, Alan Ashworth, Feijoo-Carnero, Carmen, Cantrell, Doreen, Tamas, Peter, Rosemary Clarke, Andrew Macintyre, Ashworth, Alan   +12 more
core   +1 more source

Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice [PDF]

Infection and Immunity, 1996
Mice deficient in either alpha beta or gamma delta T cells were more susceptible to infection with the protozoan parasite Cryptosporidium parvum than were control mice. Both neonatal and adult alpha beta-T-cell-deficient mice developed chronic infection. Gamma delta-T-cell-deficient neonatal mice were more susceptible than control mice but were able to
W R, Waters, J A, Harp
openaire   +2 more sources

Cord blood Vα24-Vβ11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses [PDF]

, 2011
Background: The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established. Natural killer T (NKT) cells are a rare subset of T cells with immune regulatory functions and are already activated in utero ...
Elfriede Noessner, Krauss-Etschmann, S., Faber Fabienne L., Harner, Susanne, Harner, S., Nadas, Korinna, Leumann-Runge Anke, Leumann-Runge, A., Leumann-Runge, Anke, Susanne Harner, Korinna Nadas, Nadas, K., Joachim Heinrich, Heinrich, Joachim, Fabienne L Faber, Nadas Korinna, Heinrich, J., Noessner Elfriede, Noessner, Elfriede, Anke Leumann-Runge, Schiemann, Matthias, Susanne Krauss-Etschmann, Krauss-Etschmann Susanne, Fabienne L. Faber, Schiemann Matthias, Nößner, E., Faber, Fabienne L., Krauss-Etschmann, Susanne, Schiemann, M., Faber, F.L., Heinrich Joachim, Harner Susanne, Matthias Schiemann   +32 more
core   +1 more source

Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

Nature Communications, 2018
T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR ...
Yair Razvag, Yair Neve-Oz, Julia Sajman, Meital Reches, Eilon Sherman   +4 more
doaj   +1 more source

Generation of diffuse large B cell lymphoma-associated antigen-specific Vα6/Vβ13+T cells by TCR gene transfer

Journal of Hematology & Oncology, 2011
Background Our previous study had amplified antigen-specific full-length TCR α and β genes of clonally expanded T cells in the peripheral blood (PB) of patients with diffuse large B-cell lymphoma (DLBCL).
Zhou Yubing, Chen Shaohua, Yang Lijian, Zha Xianfeng, Yin Qingsong, Wu Xiuli, Li Yangqiu   +6 more
doaj   +1 more source

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation [PDF]

, 2009
We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V, Ross, Susan E, Rowbotham, Nicola J, Crompton, T, Hager-Theodorides, Ariadne L, Shah, DK, Shah, Divya K, Drakopoulou, Ekati, Lanske, Beate, Crompton, Tessa, Dessens, Johannes T, Drakopoulou, E, Rowbotham, NJ, Dessens, JT, Ross, SE, Lanske, B, Outram, SV, Hager-Theodorides, AL   +17 more
core   +1 more source