Results 11 to 20 of about 96,959 (285)

Monitoring the T-cell receptor repertoire at single-clone resolution. [PDF]

PLoS ONE, 2006
The adaptive immune system recognizes billions of unique antigens using highly variable T-cell receptors. The alphabeta T-cell receptor repertoire includes an estimated 10(6) different rearranged beta chains per individual.
Hendrik P J Bonarius, Frank Baas, Ester B M Remmerswaal, René A W van Lier, Ineke J M ten Berge, Paul P Tak, Niek de Vries   +6 more
doaj   +6 more sources

The canine T cell receptor repertoire. [PDF]

Immunohorizons
Abstract Background Tseek is a method of sequencing T cell receptor (TCR) repertoires with minimal bias. This work aimed to develop methods to characterize the TCR repertoire in dogs, identify influences such as genetic lineage and age, and evaluate the use of repertoires to monitor immune status in ...
Allaway D, Harrison M, Pink C, Haydock R, Jayaprakash AD, Sachidanandam R.   +5 more
europepmc   +4 more sources

Overview of methodologies for T-cell receptor repertoire analysis

BMC Biotechnology, 2017
Background The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response.
Elisa Rosati, C Marie Dowds, Evaggelia Liaskou, Eva Kristine Klemsdal Henriksen, Tom H Karlsen, Andre Franke   +5 more
doaj   +3 more sources

Circulating T-cell receptor repertoire for cancer early detection [PDF]

npj Precision Oncology
Liquid biopsy is a promising non-invasive technology that is capable of diagnosing cancer. However, current ctDNA-based approaches detect only a minority of early-stage disease.
Yilong Li, Michelle Nahas, Dennis Stephens, Kate Froburg, Emma Hintz, Devin Champagne, Amaneet Lochab, Markus Brown, Jasper Braun, María Antonia Fortuño, María-del-Mar Ocón, Andrea Pasquier, Inés Luque-Vázquez, Hita Moudgalya, Sophie Kivlehan, Iliana Gjeci, Stephanie L. Korle, Arantza Campo, Maria Rodriguez, Christopher W. Seder, Patrick H. Lizotte, Raphael Bueno, Jeffrey A. Borgia, Luis M. Seijo, Luis M. Montuenga, Roman Yelensky   +25 more
doaj   +2 more sources

Quantitative analysis of the T cell receptor repertoire

, 2019
The T cell receptor repertoire provides a window into the cellular adaptive immune response. In the context of cancer, determining the repertoire within a tumor can give important insights into the evolution of the T cell anti-cancer response, and has ...
Husovsky, C, Ronel, T, Connor Husovsky, Ismail, M, Annemarie Woolston, Uddin, I, Tahel Ronel, Kroopa Joshi, Woolston, A, Benny Chain, Mazlina Ismail, Thomas Peacock, Joshi, K, Imran Uddin, Chain, B, Peacock, T   +15 more
core   +4 more sources

Single-cell T-cell receptor repertoire profiling in dogs [PDF]

Communications Biology
Spontaneous cancers in companion dogs are robust models of human disease. Tracking tumor-specific immune responses in these models requires reagents to perform species-specific single cell T cell receptor sequencing (scTCRseq).
My H. Hoang, Zachary L. Skidmore, Hans Rindt, Shirley Chu, Bryan Fisk, Jennifer A. Foltz, Catrina Fronick, Robert Fulton, Mingyi Zhou, Nathan J. Bivens, Carol N. Reinero, Todd A. Fehniger, Malachi Griffith, Jeffrey N. Bryan, Obi L. Griffith   +14 more
doaj   +2 more sources

MaGiK Method of T-Cell Receptor Repertoire Analysis [PDF]

Clinical and Vaccine Immunology, 2002
T-cell receptor diversity enables the cellular immune response to recognize a broad range of viral and other pathogenic agents. An increasingly common method of characterizing T-cell receptor diversity and usage in response to antigenic challenges ...
Janis V. Giorgi, Beth D. Jamieson, M. Scott Killian, Roger Detels, Jose Matud   +4 more
core   +3 more sources

TCR_Explore: A novel webtool for T cell receptor repertoire analysis

Computational and Structural Biotechnology Journal, 2023
T cells expressing either alpha-beta or gamma-delta T cell receptors (TCR) are critical sentinels of the adaptive immune system, with receptor diversity being essential for protective immunity against a broad array of pathogens and agents.
Kerry A. Mullan, Justin B. Zhang, Claerwen M. Jones, Shawn J.R. Goh, Jerico Revote, Patricia T. Illing, Anthony W. Purcell, Nicole L. La Gruta, Chen Li, Nicole A. Mifsud   +9 more
doaj   +3 more sources

Characterization of T cell receptor repertoire in penile cancer. [PDF]

Cancer Immunol Immunother
AbstractTumor-infiltrating lymphocytes (TILs) play a key role in regulating the host immune response and shaping tumor microenvironment. It has been previously shown that T cell infiltration in penile tumors was associated with clinical outcomes. However, few studies have reported the T cell receptor (TCR) repertoire in patients with penile cancer.
Zhang J, Wang Y, Huang Y, Tan X, Xu J, Yan Q, Tan J, Zhang Y, Zhang J, Ma Q, Zhu H, Ye J, Zhu Z, Lan W.   +13 more
europepmc   +3 more sources

Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy. [PDF]

Biomark Res
AbstractImmunoglobulin A nephropathy (IgAN) is an autoimmune disease characterized by abnormal IgA deposition in glomerulus. Current diagnosis of IgAN still depends on renal biopsy, an invasive method that might increase the risk of clinical outcomes. Therefore, we aimed to explore the characteristics of T cell repertoire in IgAN from peripheral blood ...
Ho SY, Kao CC, Chang CM, Chou YC, Luo WT, Chou WH, Tsai IL, Wu MS, Chang WC.   +8 more
europepmc   +4 more sources