Results 1 to 10 of about 95,123 (301)

Single-cell T-cell receptor repertoire profiling in dogs [PDF]

Communications Biology
Spontaneous cancers in companion dogs are robust models of human disease. Tracking tumor-specific immune responses in these models requires reagents to perform species-specific single cell T cell receptor sequencing (scTCRseq).
My H. Hoang, Zachary L. Skidmore, Hans Rindt, Shirley Chu, Bryan Fisk, Jennifer A. Foltz, Catrina Fronick, Robert Fulton, Mingyi Zhou, Nathan J. Bivens, Carol N. Reinero, Todd A. Fehniger, Malachi Griffith, Jeffrey N. Bryan, Obi L. Griffith   +14 more
doaj   +5 more sources

The canine T cell receptor repertoire. [PDF]

Immunohorizons
Abstract Background Tseek is a method of sequencing T cell receptor (TCR) repertoires with minimal bias. This work aimed to develop methods to characterize the TCR repertoire in dogs, identify influences such as genetic lineage and age, and evaluate the use of repertoires to monitor immune status in ...
Allaway D, Harrison M, Pink C, Haydock R, Jayaprakash AD, Sachidanandam R.   +5 more
europepmc   +4 more sources

Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy [PDF]

Biomarker Research
Immunoglobulin A nephropathy (IgAN) is an autoimmune disease characterized by abnormal IgA deposition in glomerulus. Current diagnosis of IgAN still depends on renal biopsy, an invasive method that might increase the risk of clinical outcomes. Therefore,
Szu-Ying Ho, Chih-Chin Kao, Che-Mai Chang, Yi-Chien Chou, Wei-Tzu Luo, Wan-Hsuan Chou, I-Lin Tsai, Mai-Szu Wu, Wei-Chiao Chang   +8 more
doaj   +4 more sources

Circulating T-cell receptor repertoire for cancer early detection [PDF]

npj Precision Oncology
Liquid biopsy is a promising non-invasive technology that is capable of diagnosing cancer. However, current ctDNA-based approaches detect only a minority of early-stage disease.
Yilong Li, Michelle Nahas, Dennis Stephens, Kate Froburg, Emma Hintz, Devin Champagne, Amaneet Lochab, Markus Brown, Jasper Braun, María Antonia Fortuño, María-del-Mar Ocón, Andrea Pasquier, Inés Luque-Vázquez, Hita Moudgalya, Sophie Kivlehan, Iliana Gjeci, Stephanie L. Korle, Arantza Campo, Maria Rodriguez, Christopher W. Seder, Patrick H. Lizotte, Raphael Bueno, Jeffrey A. Borgia, Luis M. Seijo, Luis M. Montuenga, Roman Yelensky   +25 more
doaj   +2 more sources

Overview of methodologies for T-cell receptor repertoire analysis

BMC Biotechnology, 2017
Background The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response.
Elisa Rosati, C Marie Dowds, Evaggelia Liaskou, Eva Kristine Klemsdal Henriksen, Tom H Karlsen, Andre Franke   +5 more
doaj   +3 more sources

Time-spatial analysis of T cell receptor repertoire in esophageal squamous cell carcinoma patients treated with combined radiotherapy and PD-1 blockade

OncoImmunology, 2022
T cell receptor (TCR) repertoire as a biomarker for predicting immunotherapy efficiency has been widely studied. However, its dynamics during radiotherapy combined with PD-1 blockade is little known. Using paired tumor and blood samples from the phase Ib
Cihui Yan, Xiaoxue Ma, Zhoubo Guo, Xiaoying Wei, Dong Han, Tian Zhang, Xi Chen, Fuliang Cao, Jie Dong, Gang Zhao, Xuan Gao, Tao Wang, Yao Jiang, Ping Wang, Qingsong Pang, Wencheng Zhang   +15 more
doaj   +2 more sources

Characterization of T cell receptor repertoire in penile cancer. [PDF]

Cancer Immunol Immunother
AbstractTumor-infiltrating lymphocytes (TILs) play a key role in regulating the host immune response and shaping tumor microenvironment. It has been previously shown that T cell infiltration in penile tumors was associated with clinical outcomes. However, few studies have reported the T cell receptor (TCR) repertoire in patients with penile cancer.
Zhang J, Wang Y, Huang Y, Tan X, Xu J, Yan Q, Tan J, Zhang Y, Zhang J, Ma Q, Zhu H, Ye J, Zhu Z, Lan W.   +13 more
europepmc   +3 more sources

Tissue determinants of the human T cell receptor repertoire.

98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors' autologous blood and tonsils and sought to answer key questions about T cell receptor biology previously unanswerable by smaller-scale experiments.
Sureshchandra S, Henderson J, Levendosky E, Bhattacharyya S, Kastenschmidt JM, Sorn AM, Mitul MT, Benchorin A, Batucal K, Daugherty A, Murphy SJ, Thakur C, Trask D, Ahuja G, Moisan A, Tiffeau-Mayer A, Saligrama N, Wagar LE.   +17 more
europepmc   +3 more sources

T cell receptor repertoire analysis in HTLV-1-associated diseases

Frontiers in Immunology, 2022
Human T lymphotropic virus 1 (HTLV-1) is a human retrovirus identified as the causative agent in adult T-cell leukemia/lymphoma (ATL) and chronic-progressive neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP ...
Annaliese Clauze, Yoshimi Enose-Akahata, Steven Jacobson   +2 more
doaj   +1 more source

Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment

Frontiers in Immunology, 2021
ObjectiveIn people living with HIV (PLHIV), we sought to test the hypothesis that long term anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional relationship of residual repertoire abnormalities to persistent ...
Carolin T. Turner, James Brown, James Brown, Emily Shaw, Imran Uddin, Evdokia Tsaliki, Jennifer K. Roe, Gabriele Pollara, Yuxin Sun, James M. Heather, Marc Lipman, Marc Lipman, Benny Chain, Mahdad Noursadeghi   +13 more
doaj   +1 more source