Results 41 to 50 of about 95,123 (301)

Studies on the affinity control of T cell development [PDF]

, 2004
Defined interactions between thymocytes and thymic antigen presenting cells ensure that each T cell found in an individual is both self-restricted and self-tolerant.
Naeher, Dieter
core   +1 more source

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules [PDF]

, 1992
Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and , is still poorly understood.
Wegener, Anne-Marie K., Bernard Malissen, Malissen, Bernard, Frederle Luton, Brocker, Thomas, Frédéric Luton, François Letourneur, Frant :is Letourneur, Letourneur, François, Anne-marie K. Wegener, Thomas Brocker, Letourneur, F., Arnd Hoeveler, Thomas Broeker, Brocker, T., Hoeveler, Arnd, Wegener, Am, Hoeveler, A., Luton, Frédéric, Luton, F.   +19 more
core   +1 more source

TCR_Explore: A novel webtool for T cell receptor repertoire analysis

Computational and Structural Biotechnology Journal, 2023
T cells expressing either alpha-beta or gamma-delta T cell receptors (TCR) are critical sentinels of the adaptive immune system, with receptor diversity being essential for protective immunity against a broad array of pathogens and agents.
Kerry A. Mullan, Justin B. Zhang, Claerwen M. Jones, Shawn J.R. Goh, Jerico Revote, Patricia T. Illing, Anthony W. Purcell, Nicole L. La Gruta, Chen Li, Nicole A. Mifsud   +9 more
doaj   +1 more source

Characterization of human cytomegalovirus peptide-specific CD8⁺ T-cell repertoire diversity following in vitro restimulation by antigen-pulsed dendritic cells

, 2002
Under conditions of impaired T-cell immunity, human cytomegalovirus (HCMV) can reactivate from lifelong latency, resulting in potentially fatal disease.
Moss, Paul; id_orcid, Karl Peggs, Moss, P, Pizzey, A, Stephanie Verfuerth, Ainsworth, Jennifer, Peggs, K, Verfuerth, S, Mackinnon, S, Ainsworth, J, Paul Moss, Stephen Mackinnon, Jenni Ainsworth, Arnold Pizzey   +13 more
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CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma. [PDF]

, 2012
The Salmonella type III secretion system (T3SS) efficiently translocates heterologous proteins into the cytosol of eukaryotic cells. This leads to an antigen-specific CD8 T-cell induction in mice orally immunized with recombinant Salmonella. Recently, we
Jellbauer, Stefan, Hetrodt, Justin H., Justin H Hetrodt, Rüssmann, Holger, Stefan Jellbauer, Klaus Panthel, Holger Rüssmann, Panthel, Klaus   +7 more
core   +1 more source

Cellular-level versus receptor-level response threshold hierarchies in T-Cell activation [PDF]

, 2013
Peptide-MHC (pMHC) ligand engagement by T-cell receptors (TCRs) elicits a variety of cellular responses, some of which require substantially more TCR-mediated stimulation than others.
Andrew Kelvin Sewell, van den Berg, Hugo A., Kelly Miners, Bruno eLaugel, Sian eLlewellyn-Lacey, David A Price, Linda eWooldridge, Price, David A, Laugel, Bruno, Price, D. A., Kristin eLadell, Mathew Clement, David K Cole, Sewell, Andrew K, Cole, David K., van den Berg, Hugo A, Kelly eMiners, Emma eGostick, David A. Price, Llewellyn-Lacey, Sian, Linda Wooldridge, John S. Bridgeman, Hugo A. van den Berg, Gostick, Emma, Clement, Mathew, Berg, Hugo van den, Sian Llewellyn-Lacey, David K. Cole, Cole, David K, Bruno Laugel, John Stephen Bridgeman, Kristin Ladell, Emma Gostick, Sewell, Andrew K., Ladell, Kristin, Miners, Kelly, Bridgeman, John S., Price, David, Hugo Antonius van den Berg, Andrew K. Sewell, Bridgeman, John S, Cole, David, Wooldridge, Linda, Wooldridge, L., Mathew eClement   +44 more
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T cell receptor sequence clustering and antigen specificity

Computational and Structural Biotechnology Journal, 2020
There has been increasing interest in the role of T cells and their involvement in cancer, autoimmune and infectious diseases. However, the nature of T cell receptor (TCR) epitope recognition at a repertoire level is not yet fully understood.
Milena Vujovic, Kristine Fredlund Degn, Frederikke Isa Marin, Anna-Lisa Schaap-Johansen, Benny Chain, Thomas Lars Andresen, Joseph Kaplinsky, Paolo Marcatili   +7 more
doaj   +1 more source

T-cell receptors: Is the repertoire inherently MHC-specific? [PDF]

Current Biology, 1997
A debate over whether the observed specificity of the naive T-cell receptor repertoire for major histocompatibility complex molecules arises before or after selection within the thymus has apparently been settled in favour of the former by a series of new experiments.
Janeway, C A, Chervonsky, A V, Sant'Angelo, D   +2 more
openaire   +2 more sources

T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder

Frontiers in Immunology, 2018
While a link between inflammation and the development of neuropsychiatric disorders, including major depressive disorder (MDD) is supported by a growing body of evidence, little is known about the contribution of aberrant adaptive immunity in this ...
Kostas Patas, Anne Willing, Cüneyt Demiralay, Jan Broder Engler, Andreea Lupu, Andreea Lupu, Caren Ramien, Tobias Schäfer, Christian Gach, Laura Stumm, Kenneth Chan, Marissa Vignali, Petra C. Arck, Manuel A. Friese, Ole Pless, Klaus Wiedemann, Agorastos Agorastos, Stefan M. Gold, Stefan M. Gold   +18 more
doaj   +1 more source

T Cell Receptor Repertoire Analysis Reveals Signatures of T Cell Responses to Human Mycobacterium tuberculosis

Frontiers in Microbiology, 2022
Characterization of T cell receptor (TCR) repertoires is essential for understanding the mechanisms of Mycobacterium tuberculosis (Mtb) infection involving T cell adaptive immunity.
Ming-Ming Shao, Feng-Shuang Yi, Zhong-Yin Huang, Peng Peng, Feng-Yao Wu, Huan-Zhong Shi, Kan Zhai   +6 more
doaj   +1 more source