Complementarity determining regions in SARS-CoV-2 hybrid immunity [PDF]
Frontiers in Immunology, 2023 Pre-vaccination SARS-CoV-2 infection can boost protection elicited by COVID-19 vaccination and post-vaccination breakthrough SARS-CoV-2 infection can boost existing immunity conferred by COVID-19 vaccination.
Glynis Frans +19 more
doaj +7 more sources
A complete, multi-level conformational clustering of antibody complementarity-determining regions [PDF]
PeerJ, 2014 Classification of antibody complementarity-determining region (CDR) conformations is an important step that drives antibody modelling and engineering, prediction from sequence, directed mutagenesis and induced-fit studies, and allows inferences on ...
Dimitris Nikoloudis +2 more
doaj +6 more sources
Understanding the impacts of dual methionine oxidations in complementarity-determining regions on the structure of monoclonal antibodies [PDF]
mAbsMethionine oxidation can substantially alter the structure and functionality of monoclonal antibodies (mAbs), especially when it occurs in the complementarity-determining regions (CDRs).
Bo Zhao +8 more
doaj +4 more sources
Contributions of the complementarity determining regions to the thermal stability of a single-domain antibody. [PDF]
PLoS ONE, 2013 Single domain antibodies (sdAbs) are the recombinantly-expressed variable domain from camelid (or shark) heavy chain only antibodies and provide rugged recognition elements.
Dan Zabetakis +3 more
doaj +5 more sources
A novel heavy domain antibody library with functionally optimized complementarity determining regions. [PDF]
PLoS ONE, 2013 Today a number of synthetic antibody libraries of different formats have been created and used for the selection of a large number of recombinant antibodies. One of the determining factors for successful isolation of recombinant antibodies from libraries
Ole Aalund Mandrup +4 more
doaj +6 more sources
Principles of antibodies with ultralong complementarity-determining regions and picobodies
Biotechnology Advances, 2023 In contrast to other species, cattle possess exceptional antibodies with ultra-long complementarity-determining regions (ulCDRs) that can consist of 40-70 amino acids. The bovine ulCDR is folded into a stalk and a disulfide-rich knob domain. The binding to the antigen is via the 3-6 kDa knob. There exists an immense sequence and structural diversity in
Marcel Passon +2 more
exaly +4 more sources
Complementarity determining regions and frameworks contribute to the disulfide bond independent folding of intrinsically stable scFv. [PDF]
PLoS ONE, 2017 CyDisCo is a system facilitating disulfide bond formation in recombinant proteins in the cytoplasm of Escherichia coli. Previously we screened for soluble expression of single chain antibody fragments (scFv) in the cytoplasm of E.
Anna Gąciarz, Lloyd W Ruddock
doaj +2 more sources
The complementarity-determining region sequences in IgY antivenom hypervariable regions
Data in Brief, 2017 The data presented in this article are related to the research article entitled ''Development of IgY antibodies against anti-snake toxins endowed with highly lethal neutralizing activity'' (da Rocha et al., 2017) [1].
David Gitirana da Rocha +6 more
doaj +3 more sources
Net charge of antibody complementarity-determining regions is a key predictor of specificity. [PDF]
Protein Eng Des Sel, 2018 Abstract Specificity is one of the most important and complex properties that is central to both natural antibody function and therapeutic antibody efficacy. However, it has proven extremely challenging to define robust guidelines for predicting antibody specificity.
Rabia LA +4 more
europepmc +4 more sources
Antibody complementarity-determining regions (CDRs): a bridge between adaptive and innate immunity. [PDF]
PLoS ONE, 2009 BACKGROUND:It has been documented that, independently from the specificity of the native antibody (Ab) for a given antigen (Ag), complementarity determining regions (CDR)-related peptides may display differential antimicrobial, antiviral and antitumor ...
Elena Gabrielli +9 more
doaj +2 more sources