Results 41 to 50 of about 25,476 (265)

Soluble T Cell Receptor Vβ Domains Engineered for High-Affinity Binding to Staphylococcal or Streptococcal Superantigens

Toxins, 2014
Staphylococcus aureus and group A Streptococcus secrete a collection of toxins called superantigens (SAgs), so-called because they stimulate a large fraction of an individual’s T cells.
Preeti Sharma, Ningyan Wang, David M. Kranz   +2 more
doaj   +1 more source

Mass spectrometry-based analysis of rheumatoid factor

Frontiers in Immunology
IntroductionRheumatoid factor (RF) are autoantibodies that are found in approximately two thirds of patients with rheumatoid arthritis, a chronic autoimmune disease characterized by potentially destructive inflammation of the joints.
Jonas De Leeuw, Jonas De Leeuw, Birthe Michiels, Birthe Michiels, Rita Derua, Rita Derua, Tom Dehaemers, Tom Dehaemers, Doreen Dillaerts, Doreen Dillaerts, Maaike Cockx, Maaike Cockx, Maaike Cockx, Glynis Frans, Glynis Frans, Sebastien Christian Carpentier, Patrick Verschueren, Patrick Verschueren, Xavier Bossuyt, Xavier Bossuyt   +19 more
doaj   +1 more source

KA-Search, a method for rapid and exhaustive sequence identity search of known antibodies

Scientific Reports, 2023
Antibodies with similar amino acid sequences, especially across their complementarity-determining regions, often share properties. Finding that an antibody of interest has a similar sequence to naturally expressed antibodies in healthy or diseased ...
Tobias H. Olsen, Brennan Abanades, Iain H. Moal, Charlotte M. Deane   +3 more
doaj   +1 more source

High-Resolution IMSMS to Assign Additional Disulfide Bridge Pairing in Complementarity-Determining Regions of an IgG4 Monoclonal Antibody [PDF]

, 2021
Monoclonal antibodies (mAbs) have taken on an increasing importance for the treatment of various diseases, including cancers and immunological disorders.
Alain Beck (1413784), Sarah Cianférani (1530466), Thomas Botzanowski, Olivier Colas, Guillaume Béchade, Alain Beck, Sarah Cianférani, Dale A. Cooper-Shepherd (11338564), Oscar Hernandez-Alba (4738647), Elsa Wagner-Rousset, Oscar Hernandez-Alba, Guillaume Béchade (2365348), Evolène Deslignière, Hélène Diemer (1624273), Kevin Giles, Elsa Wagner-Rousset (1624276), Olivier Colas (1624279), Dale A. Cooper-Shepherd, Thomas Botzanowski (4723509), Hélène Diemer, Evolène Deslignière (8908949), Kevin Giles (2029252)   +21 more
core   +3 more sources

Different properties of T-cell epitopes within complementarity-determining regions 1 and 2 of idiotypic VH in B-lymphoma [PDF]

, 1999
The idiotypic protein expressed by B-lymphoma cells can evoke an autologous idiotype-specific T-cell response in both animal studies and lymphoma patients. However, the locations within the idiotypic protein of the immune epitopes remains unclear.
Wen, Y. J., Lim, Seah H.
core   +1 more source

Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris [PDF]

AMB Express, 2019
Easy preparation of chimeric nanobodies with various scaffolds is important for customizing abilities of nanobodies toward practical utilization. To accomplish high-throughput production of various nanobodies, utilization of microbes is an attractive option.
Miura, Natsuko, Miyamoto, Kana, Ohtani, Yuta, Yaginuma, Kenshi, Aburaya, Shunsuke, Kitagawa, Yoshinori, Aoki, Wataru, Ueda, Mitsuyoshi   +7 more
openaire   +3 more sources

Investigating the ability of deep learning-based structure prediction to extrapolate and/or enrich the set of antibody CDR canonical forms

Frontiers in Immunology
Deep learning models have been shown to accurately predict protein structure from sequence, allowing researchers to explore protein space from the structural viewpoint.
Alexander Greenshields-Watson, Brennan Abanades, Charlotte M. Deane   +2 more
doaj   +1 more source

Immune Repertoire Profiling Reveals that Clonally Expanded B and T Cells Infiltrating Diseased Human Kidneys Can Also Be Tracked in Blood. [PDF]

PLoS ONE, 2015
Recent advances in high-throughput sequencing allow for the competitive analysis of the human B and T cell immune repertoire. In this study we compared Immunoglobulin and T cell receptor repertoires of lymphocytes found in kidney and blood samples of 10 ...
Johannes Weinberger, Raul Jimenez-Heredia, Susanne Schaller, Susanne Suessner, Judith Sunzenauer, Roman Reindl-Schwaighofer, Richard Weiss, Stephan Winkler, Christian Gabriel, Martin Danzer, Rainer Oberbauer   +10 more
doaj   +1 more source

A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production

Frontiers in Immunology, 2022
The diversity of three hypervariable loops in antibody heavy chain and light chain, termed the complementarity-determining regions (CDRs), defines antibody’s binding affinity and specificity owing to the direct contact between the CDRs and antigens ...
Xiaotian Zhong, Aaron M. D’Antona
doaj   +1 more source

Deciphering the antigen specificities of antibodies by clustering their complementarity determining region sequences

mSystems, 2023
ABSTRACT Recent advances in adaptive immune receptor repertoire sequencing have provided abundant B cell receptor (BCR) sequences under various conditions, including vaccination and disease. However, determining target antigen and epitope specificity of the corresponding antibodies is a major challenge due to their exceptional sequence ...
Saputri, Dianita S., Ismanto, Hendra S., Nugraha, Dendi K., Xu, Zichang, Horiguchi, Yasuhiko, Sakakibara, Shuhei, Standley, Daron M., Cristea, Ileana M.   +7 more
openaire   +4 more sources