Development of the global competitiveness of Russian regions: the concept and configuration of the "smart" complementarity [PDF]
Модернизация, инновация, развитиеPurpose: is to work out the scientifically sound theoretical and methodical framework for the «smart» complementarity of trade flows, aimed at selecting and substantiating potential commodity niches in trade of Russian regions with foreign countries ...
M. V. Kurnikova
doaj +3 more sources
AntibodyFlow: Normalizing Flow Model for Designing Antibody Complementarity-Determining Regions [PDF]
CoRRTherapeutic antibodies have been extensively studied in drug discovery and development in the past decades. Antibodies are specialized protective proteins that bind to antigens in a lock-to-key manner. The binding strength/affinity between an antibody and a specific antigen is heavily determined by the complementarity-determining regions (CDRs) on the ...
Bohao Xu +3 more
openaire +3 more sources
Antibody Complementarity Determining Region Design Using High-Capacity Machine Learning [PDF]
Bioinformatics, 2019 Abstract The precise targeting of antibodies and other protein therapeutics is required for their proper function and the elimination of deleterious off-target effects. Often the molecular structure of a therapeutic target is unknown and randomized methods are used to design antibodies without a model that relates antibody sequence to ...
Ge Liu +9 more
openaire +5 more sources
Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs [PDF]
Journal of Biological Chemistry, 2017 Lijuan Li +2 more
exaly +2 more sources
Quantitative Description of Surface Complementarity of Antibody-Antigen Interfaces
Frontiers in Molecular Biosciences, 2021 Antibodies have the remarkable ability to recognise their cognate antigens with extraordinary affinity and specificity. Discerning the rules that define antibody-antigen recognition is a fundamental step in the rational design and engineering of ...
Lorenzo Di Rienzo +5 more
doaj +1 more source
De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide. [PDF]
Sci Rep, 2017 Computational antibody engineering efforts to date have focused on improving binding affinities or biophysical characteristics. De novo design of antibodies binding specific epitopes could greatly accelerate discovery of therapeutics as compared to ...
Entzminger KC +10 more
europepmc +2 more sources
mAbs, 2022 Self-association governs the viscosity and solubility of therapeutic antibodies in high-concentration formulations used for subcutaneous delivery, yet it is difficult to reliably identify candidates with low self-association during antibody discovery and
Emily K. Makowski +14 more
doaj +1 more source
Predicting the conformational flexibility of antibody and T cell receptor complementarity-determining regions. [PDF]
Nat Mach IntellMany proteins are highly flexible and their ability to adapt their shape can be fundamental to their functional properties. For example, the flexibility of antibody complementarity-determining region (CDR) loops influences binding affinity and ...
Spoendlin FC +10 more
europepmc +3 more sources
Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction [PDF]
PeerJ, 2020 Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface.
Akhila Melarkode Vattekatte +9 more
doaj +2 more sources
mAbs, 2020 Antibody variable domains contain “complementarity-determining regions” (CDRs), the loops that form the antigen binding site. CDRs1-3 are recognized as the canonical CDRs.
Simon P. Kelow +2 more
doaj +1 more source