Results 51 to 60 of about 95,123 (301)

Regional and global changes in TCR [alpha][beta] T cell repertoires in the gut are dependent upon the complexity of the enteric microflora

, 2010
The repertoire of gut associated T cells is shaped by exposure to microbes, including the natural enteric microflora. Previous studies compared the repertoire of gut associated T cell populations in germ free (GF) and conventional mammals often focussing
Beal, R.K., Smith, A.L., Tom Humphrey, Friedman, A., Friedman, A, Beal, RK, Bailey, M, Adrian L. Smith, Humphrey, T., Claire Powers, Wu, X, Bailey, M., William N. Mwangi, Mwangi, WN, Smith, Adrian, Watson, M, Xikun Wu, Mwangi, W.N., Richard K. Beal, Michael Watson, Humphrey, TJ, Wu, X., Humphrey, T, Watson, Mick, Smith, AL, Aharon Friedman, Powers, C, Powers, C., Michael Bailey   +28 more
core   +1 more source

T-Cell activation: a queuing theory analysis at low agonist density [PDF]

, 2006
We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J.R., Burroughs, N.J., Burroughs, Nigel John, Wedagedera, J. R.   +3 more
core   +1 more source

Applicability of T cell receptor repertoire sequencing analysis to unbalanced clinical samples – comparing the T cell receptor repertoire of GATA2 deficient patients and healthy controls

Swiss Medical Weekly, 2023
T cell receptor repertoire sequencing (TCRseq) has become one of the major omic tools to study the immune system in health and disease. Multiple commercial solutions are currently available, greatly facilitating the implementation of this complex method
Valentin von Niederhäusern, Marie Ghraichy, Johannes Trück   +2 more
doaj   +1 more source

Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection

Frontiers in Immunology, 2021
It is intriguing that, unlike adults with HIV-1, children with HIV-1 reach a greater CD4+ T cell recovery following planned treatment cessation. The reasons for the better outcomes in children remain unknown but may be related to increased thymic output ...
Katrine Schou Sandgaard, Katrine Schou Sandgaard, Ben Margetts, Teresa Attenborough, Teresa Attenborough, Triantafylia Gkouleli, Stuart Adams, Mette Holm, Diana Gibb, Deena Gibbons, Carlo Giaquinto, Anita De Rossi, Anita De Rossi, Alasdair Bamford, Alasdair Bamford, Alasdair Bamford, Paolo Palma, Benny Chain, Athina S. Gkazi, Nigel Klein   +19 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Studies of suppression using monoclonal regulatory T cells and the importance of co-receptor Lck coupling ratios for negative selection [PDF]

, 2015
Normal physiology is not given without immunological tolerance. Depending on the origin of induction, tolerance can be divided into central and peripheral tolerance.
Gubser, Céline
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Lymphocyte homeostasis is maintained in perinatally HIV-infected patients after three decades of life

Immunity & Ageing, 2019
Background While immunosenescence, defined as reduced production of new lymphocytes, restriction of T-cell receptor repertoire and telomeres shortening, has been extensively evaluated in HIV-infected children and adults, no data about these parameters ...
S. Paghera, E. Quiros-Roldan, A. Sottini, M. Properzi, F. Castelli, L. Imberti   +5 more
doaj   +1 more source

Reduced diversity of intestinal T-cell receptor repertoire in patients with Crohn’s disease

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundThe intestinal microenvironment directly determines the human T-cell receptor (TCR) repertoire. Despite its extreme diversity, TCR repertoire analysis may provide a better understanding of the immune system in patients with inflammatory bowel ...
Sung Noh Hong, Sung Noh Hong, Joo-Young Park, So-Yun Yang, Chansu Lee, Chansu Lee, Young-Ho Kim, Je-Gun Joung   +7 more
doaj   +1 more source

Rapid Assessment of T-Cell Receptor Specificity of the Immune Repertoire [PDF]

Nature Computational Science, 2020
Abstract Accurate assessment of TCR-antigen specificity at the whole immune repertoire level lies at the heart of improved cancer immunotherapy, but predictive models capable of high-throughput assessment of TCR-peptide pairs are lacking.
Xingcheng Lin, Jason T. George, Nicholas P. Schafer, Kevin Ng Chau, Michael E. Birnbaum, Cecilia Clementi, José N. Onuchic, Herbert Levine   +7 more
openaire   +4 more sources