Results 31 to 40 of about 95,123 (301)

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

The LCMV gp33-specific memory T cell repertoire narrows with age

Immunity & Ageing, 2012
Background The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease.
Bunztman Adam, Vincent Benjamin G, Krovi Harsha, Steele Shaun, Frelinger Jeffrey A   +4 more
doaj   +1 more source

Immune Repertoire Profiling Reveals that Clonally Expanded B and T Cells Infiltrating Diseased Human Kidneys Can Also Be Tracked in Blood. [PDF]

PLoS ONE, 2015
Recent advances in high-throughput sequencing allow for the competitive analysis of the human B and T cell immune repertoire. In this study we compared Immunoglobulin and T cell receptor repertoires of lymphocytes found in kidney and blood samples of 10 ...
Johannes Weinberger, Raul Jimenez-Heredia, Susanne Schaller, Susanne Suessner, Judith Sunzenauer, Roman Reindl-Schwaighofer, Richard Weiss, Stephan Winkler, Christian Gabriel, Martin Danzer, Rainer Oberbauer   +10 more
doaj   +1 more source

Analysis of the T-cell receptor repertoire in human atherosclerosis [PDF]

Cardiovascular Research, 1997
Analysis of T-cell receptor (TCR) beta-chain gene expression in atherosclerotic lesions of human aorta.TCR diversity was studied using non-radioactive polymerase chain reaction for quantitative assessment of TCRBV gene transcripts, together with size and sequence analysis of the beta-chain third complementarity-determining region (CDR3).
J R, Oksenberg, G T, Stavri, M C, Jeong, N, Garovoy, J R, Salisbury, J D, Erusalimsky   +5 more
openaire   +2 more sources

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E., Heufelder, Armin E., Scriba, Peter C.   +2 more
core   +1 more source

Analysis of the paired TCR α- and β-chains of single human T cells. [PDF]

, 2012
Analysis of the paired i.e. matching TCR α- and β-chain rearrangements of single human T cells is required for a precise investigation of clonal diversity, tissue distribution and specificity of protective and pathologic T-cell mediated immune responses.
Dornmair, K., Besgen, P., Held, K., Bhonsle, L., Vollmer, Sigrid, Song-Min Kim, Jens Nickel, Anna Backes, Held, Kathrin, Vollmer, S., Joerg C Prinz, Backes Anna, Backes, A., Backes, Anna, Bhonsle, Latika, Kim Song-Min, Nickel, Jens, Sigrid Vollmer, Nickel, J., Kim, Song-Min, Klaus Dornmair, Dornmair, Klaus, Kim, S., Besgen Petra, Petra Besgen, Vollmer Sigrid, Prinz, Joerg C., Prinz Joerg C., Latika Bhonsle, Bhonsle Latika, Besgen, Petra, Held Kathrin, Prinz, J., Kathrin Held, Nickel Jens, Dornmair Klaus   +35 more
core   +1 more source

Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes

Biomedicines, 2022
The microbiome shapes the mature T cell receptor (TCR) repertoire and thereby influences pathogen control. To investigate microbiome influences on T cells at an earlier, immature stage, we compared single-cell TCR transcript sequences between CD4+CD8 ...
Sherri L. Surman, Jeremy Crawford, Pradyot Dash, Susan L. Tonkonogy, Paul G. Thomas, Julia L. Hurwitz   +5 more
doaj   +1 more source

Sampling from T Cell Receptor Repertoires [PDF]

, 2017
Modern single-cell sequencing techniques allow the unique TCR signature of each of a sample of hundreds of T cells to be read. The mathematical challenge is to extrapolate from the properties of a sample to those of the whole repertoire of an individual, made up of many millions of T cells.
Ferrarini, M, Molina-Paris, C, Lythe, G
openaire   +2 more sources

T Cell Repertoire and Inflammatory Bowel Disease

Canadian Journal of Gastroenterology, 1996
The diversity of the T cell receptor repertoire is generated through rearrangement of the variable, junctional and constant region genes. Selection processes in the thymus and periphery serve to eliminate self-reacting T cells, thereby preventing ...
Kenneth Croitoru, David KH Wong, Maria E Baca-Estrada   +2 more
doaj   +1 more source

Characterisation of T cell receptor repertoires in coeliac disease

Journal of Clinical Pathology, 2022
Aims Characterise T-cell receptor gene (TR) repertoires of small intestinal T cells of patients with newly diagnosed (active) coeliac disease (ACD), refractory CD type I (RCD I) and patients with CD on a gluten-free diet (GFD).
Lik Wee Lee, Shahin Shafiani, Beryl Crossley, Ryan O Emerson, David Williamson, Anna Bunin, Justin Vargas, Arnold S Han, Ian M Kaplan, Peter H R Green, Ilan Kirsch, Govind Bhagat   +11 more
openaire   +2 more sources