Results 11 to 20 of about 95,123 (301)

Monitoring the T-cell receptor repertoire at single-clone resolution. [PDF]

PLoS ONE, 2006
The adaptive immune system recognizes billions of unique antigens using highly variable T-cell receptors. The alphabeta T-cell receptor repertoire includes an estimated 10(6) different rearranged beta chains per individual.
Hendrik P J Bonarius, Frank Baas, Ester B M Remmerswaal, René A W van Lier, Ineke J M ten Berge, Paul P Tak, Niek de Vries   +6 more
doaj   +2 more sources

MaGiK Method of T-Cell Receptor Repertoire Analysis [PDF]

Clinical and Vaccine Immunology, 2002
ABSTRACT T-cell receptor diversity enables the cellular immune response to recognize a broad range of viral and other pathogenic agents. An increasingly common method of characterizing T-cell receptor diversity and usage in response to antigenic challenges involves the identification of clonal expansions by PCR amplification of the CDR3 ...
M Scott, Killian, Jose, Matud, Roger, Detels, Janis V, Giorgi, Beth D, Jamieson   +4 more
openaire   +3 more sources

Premature Infants Have Normal Maturation of the T Cell Receptor Repertoire at Term

Frontiers in Immunology, 2022
Premature infants are known to have immature immune systems compared to term infants; however, the impacts of ex utero immune development are not well characterized.
Sarah U. Morton, Sarah U. Morton, Maureen Schnur, Rylee Kerper, Vanessa Young, Amy E. O’Connell, Amy E. O’Connell, Amy E. O’Connell   +7 more
doaj   +1 more source

Interpreting the T-cell receptor repertoire [PDF]

Nature Biotechnology, 2017
T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one individual. Here we define the minimal requirements for TCR antigen specificity, through an analysis of TCR sequences using a panel of peptide and major histocompatibility complex (pMHC)-tetramer-sorted cells and structural data. From
Jacob Glanville, Huang Huang, Allison Nau, Olivia Hatton, Lisa E. Wagar, Florian Rubelt, Xuhuai Ji, Arnold Han, Sheri M. Krams, Christina Pettus, Nikhil Haas, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Scott D. Boyd, Thomas J. Scriba, Olivia M. Martinez, Mark M. Davis   +16 more
openaire   +4 more sources

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Frontiers in Immunology, 2023
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections, and ...
Melissa Pille, John Avila, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Guillem Sanchez Sanchez, Glenn Goetgeluk, Glenn Goetgeluk, Stijn De Munter, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Sarah Bonte, Joline Ingels, Joline Ingels, Laurenz De Cock, Laurenz De Cock, Eva Pascal, Eva Pascal, Lucas Deseins, Lucas Deseins, Tessa Kerre, Tessa Kerre, Tom Taghon, Tom Taghon, Georges Leclercq, Georges Leclercq, David Vermijlen, David Vermijlen, David Vermijlen, David Vermijlen, Brian Davis, Bart Vandekerckhove, Bart Vandekerckhove   +36 more
doaj   +1 more source

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Frontiers in Immunology, 2020
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the ...
Meriem Attaf, Meriem Attaf, Julia Roider, Julia Roider, Julia Roider, Julia Roider, Amna Malik, Cristina Rius Rafael, Cristina Rius Rafael, Garry Dolton, Garry Dolton, Andrew J. Predergast, Andrew J. Predergast, Andrew J. Predergast, Alasdair Leslie, Alasdair Leslie, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Henrik N. Kløverpris, Henrik N. Kløverpris, Andrew K. Sewell, Andrew K. Sewell, Philip J. Goulder, Philip J. Goulder   +26 more
doaj   +1 more source

Comparative Study of Repertoire Classification Methods Reveals Data Efficiency of k-mer Feature Extraction

Frontiers in Immunology, 2022
The repertoire of T cell receptors encodes various types of immunological information. Machine learning is indispensable for decoding such information from repertoire datasets measured by next-generation sequencing (NGS).
Yotaro Katayama, Tetsuya J. Kobayashi
doaj   +1 more source

The T‐cell receptor repertoire of regulatory T cells [PDF]

Immunology, 2008
SummaryThe CD4+ CD25+ regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects us from a variety of autoimmune diseases.
Rafal, Pacholczyk, Joanna, Kern
openaire   +2 more sources

Single-cell RNA-seq revealing the immune features of donor liver during liver transplantation

Frontiers in Immunology, 2023
Immune cells, including T and B cells, are key factors in the success of liver transplantation. And the repertoire of T cells and B cells plays an essential function in mechanism of the immune response associated with organ transplantation.
Yi Shan, Debin Qi, Lei Zhang, Lixue Wu, Wenfang Li, Hao Liu, Tao Li, Zhiren Fu, Haili Bao, Shaohua Song   +9 more
doaj   +1 more source

The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation

Iranian Journal of Allergy, Asthma and Immunology, 2022
Immune reconstitution after hematopoietic stem cell transplantation (HSCT) with a conditioning regimen has appeared to be a promising treatment for autoimmune diseases and hematologic malignancies.
Fahimeh Zamani, Reza Mirfakhraie, Sayyed Reza Safaee Nodehi, Yaghoub Mollaei-Kandelous, Hossein Jafari, Mohammad Farahmand, Farhad Rezaei, Majid Teymoori-Rad, Abolfazl Movafagh   +8 more
doaj   +1 more source