Results 21 to 30 of about 96,959 (285)

Tissue determinants of the human T cell receptor repertoire.

98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors' autologous blood and tonsils and sought to answer key questions about T cell receptor biology previously unanswerable by smaller-scale experiments.
Sureshchandra S, Henderson J, Levendosky E, Bhattacharyya S, Kastenschmidt JM, Sorn AM, Mitul MT, Benchorin A, Batucal K, Daugherty A, Murphy SJ, Thakur C, Trask D, Ahuja G, Moisan A, Tiffeau-Mayer A, Saligrama N, Wagar LE.   +17 more
europepmc   +3 more sources

Interpreting the T-cell receptor repertoire [PDF]

Nature Biotechnology, 2017
T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one individual. Here we define the minimal requirements for TCR antigen specificity, through an analysis of TCR sequences using a panel of peptide and major histocompatibility complex (pMHC)-tetramer-sorted cells and structural data. From
Jacob Glanville, Huang Huang, Allison Nau, Olivia Hatton, Lisa E. Wagar, Florian Rubelt, Xuhuai Ji, Arnold Han, Sheri M. Krams, Christina Pettus, Nikhil Haas, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Scott D. Boyd, Thomas J. Scriba, Olivia M. Martinez, Mark M. Davis   +16 more
openaire   +4 more sources

The T‐cell receptor repertoire of regulatory T cells [PDF]

Immunology, 2008
SummaryThe CD4+ CD25+ regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects us from a variety of autoimmune diseases.
Rafal, Pacholczyk, Joanna, Kern
openaire   +2 more sources

Perturbations of the T-cell immune repertoire in kidney transplant rejection

Frontiers in Immunology, 2022
In this cross-sectional and longitudinal analysis of mapping the T-cell repertoire in kidney transplant recipients, we have investigated and validated T-cell clonality, immune repertoire chronology at rejection, and contemporaneous allograft biopsy ...
Tara K. Sigdel, Paul A. Fields, Juliane Liberto, Izabella Damm, Maggie Kerwin, Jill Hood, Parhom Towfighi, Marina Sirota, Harlan S. Robins, Minnie M. Sarwal   +9 more
doaj   +1 more source

Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD

Frontiers in Immunology, 2020
Patients with loss-of-function mutations in IL10 or IL10 receptor (IL10R) genes develop severe, medical-refractory, infantile-onset inflammatory bowel disease (IBD).
Lael Werner, Lael Werner, Yu Nee Lee, Yu Nee Lee, Yu Nee Lee, Yu Nee Lee, Erez Rechavi, Erez Rechavi, Erez Rechavi, Erez Rechavi, Atar Lev, Atar Lev, Atar Lev, Atar Lev, Baruch Yerushalmi, Galina Ling, Neil Shah, Holm H. Uhlig, Holm H. Uhlig, Holm H. Uhlig, Batia Weiss, Batia Weiss, Raz Somech, Raz Somech, Raz Somech, Raz Somech, Scott B. Snapper, Scott B. Snapper, Dror S. Shouval, Dror S. Shouval   +29 more
doaj   +1 more source

Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years. [PDF]

PLoS Pathogens, 2012
CD8(+) T-cell responses against latent viruses can cover considerable portions of the CD8(+) T-cell compartment for many decades, yet their initiation and maintenance remains poorly characterized in humans. A key question is whether the clonal repertoire
P L Klarenbeek, E B M Remmerswaal, I J M ten Berge, M E Doorenspleet, B D C van Schaik, R E E Esveldt, S D Koch, A ten Brinke, A H C van Kampen, F J Bemelman, P P Tak, F Baas, N de Vries, R A W van Lier   +13 more
doaj   +1 more source

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults

Frontiers in Immunology, 2022
γ9δ2T cells fill a distinct niche in human immunity due to the unique physiology of the phosphoantigen-reactive γ9δ2TCR. Here, we highlight reproducible TCRδ complementarity-determining region 3 (CDR3δ) repertoire patterns associated with γ9δ2T cell ...
Anna Vyborova, Anke Janssen, Lucrezia Gatti, Froso Karaiskaki, Austin Yonika, Sanne van Dooremalen, Jasper Sanders, Dennis X. Beringer, Trudy Straetemans, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball, Jürgen Kuball   +12 more
doaj   +1 more source

Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy [PDF]

, 2013
The interaction between T-cell receptors (TCRs) and peptide epitopes is highly degenerate: a TCR is capable of interacting productively with a wide range of different peptide ligands, involving not only cross-reactivity proper (similar epitopes elicit ...
Linda Wooldridge, van den Berg, Hugo Antonius, Dockree, Tamsin, Van Den Berg, Hugo A, Berg, Hugo van den, Linda eWooldridge, Williams, Tamsin, Barbara Szomolay, Tamsin eWlliams, Tamsin Williams, Szomolay, Barbara, Hugo Antonius Van Den Berg, Barbara eSzomolay, Wooldridge, Linda   +13 more
core   +1 more source

T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing

Haematologica, 2019
Alloreactivity or opportunistic infections following allogeneic stem cell transplantation are difficult to predict and contribute to post-transplantation mortality.
Cornelia S. Link-Rachner, Anne Eugster, Elke Rücker-Braun, Falk Heidenreich, Uta Oelschlägel, Andreas Dahl, Christian Klesse, Matthias Kuhn, Jan Moritz Middeke, Martin Bornhäuser, Ezio Bonifacio, Johannes Schetelig   +11 more
doaj   +1 more source

Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden [PDF]

, 2011
BACKGROUND:The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden.
Ngom, Pa T, Solon Juan, Ngom Pa T, Andrew M Prentice, Morgan Gareth, Juan Solon, Prentice Andrew M, Richard Aspinall, Morgan, Gareth, Pa T Ngom, Prentice, Andrew M, Sophie E Moore, Aspinall, Richard, Gareth Morgan, Moore, Sophie E, Solon, Juan, Ngom, Pa T., Moore, Sophie E., Prentice, Andrew M., Aspinall Richard, Moore Sophie E   +20 more
core   +1 more source