Results 21 to 30 of about 58,781 (291)

TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes

BMC Bioinformatics, 2022
Background T cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to examine the T cell receptor (TCR) repertoire at the individual sequence level.
Meiling Liu, Juna Goo, Yang Liu, Wei Sun, Michael C. Wu, Li Hsu, Qianchuan He   +6 more
doaj   +1 more source

Huge Overlap of Individual TCR Beta Repertoires [PDF]

Frontiers in Immunology, 2013
It has been reported that human TCR repertoires commonly carry so-called public clonotypes – CDR3 variants that are often shared between individuals. Cross-comparison of individual immune repertoires has previously revealed the existence of a population of TCR beta CDR3 variants that are identical at the amino acid level for any two donors (1–3).
Mikhail eShugay, Dmitriy A Bolotin, Ekaterina V Putintseva, Mikhail V Pogorelyy, Ilgar Z Mamedov, Ilgar Z Mamedov, Dmitriy M Chudakov, Dmitriy M Chudakov   +7 more
openaire   +3 more sources

Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy [PDF]

, 2013
The interaction between T-cell receptors (TCRs) and peptide epitopes is highly degenerate: a TCR is capable of interacting productively with a wide range of different peptide ligands, involving not only cross-reactivity proper (similar epitopes elicit ...
Berg, Hugo van den, Szomolay, Barbara, Williams, Tamsin, Wooldridge, Linda   +3 more
core   +10 more sources

Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis

Frontiers in Immunology, 2022
CD8+ T cells are the key effector cells that contribute to the antitumor immune response. They comprise various T-cell clones with diverse antigen-specific T-cell receptors (TCRs).
Hiroyasu Aoki, Hiroyasu Aoki, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha   +4 more
doaj   +1 more source

A comprehensive evaluation of diversity measures for TCR repertoire profiling. [PDF]

BMC Biol
Abstract Background T cells play a crucial role in adaptive immunity, as they monitor internal and external immunogenic signals through their specific receptors (TCRs). Using high-throughput sequencing, one can assess TCR repertoire in various clinical settings and describe it quantitatively by calculating a diversity
Mika J, Polanska A, Blenman KR, Pusztai L, Polanska J, Candéias S, Marczyk M.   +6 more
europepmc   +4 more sources

Combination immunotherapy induces distinct T-cell repertoire responses when administered to patients with different malignancies. [PDF]

, 2020
BackgroundCTLA-4 blockade with ipilimumab is Food and Drug Administration-approved for melanoma as a monotherapy and has been shown to modulate the circulating T-cell repertoire.
Cham, Jason, Fong, Grant, Fong, Lawrence, He, Tao, Kwek, Serena, Oh, David Y, Paciorek, Alan, Zhang, Li   +7 more
core   +1 more source

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Frontiers in Immunology, 2020
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the ...
Meriem Attaf, Meriem Attaf, Julia Roider, Julia Roider, Julia Roider, Julia Roider, Amna Malik, Cristina Rius Rafael, Cristina Rius Rafael, Garry Dolton, Garry Dolton, Andrew J. Predergast, Andrew J. Predergast, Andrew J. Predergast, Alasdair Leslie, Alasdair Leslie, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Henrik N. Kløverpris, Henrik N. Kløverpris, Andrew K. Sewell, Andrew K. Sewell, Philip J. Goulder, Philip J. Goulder   +26 more
doaj   +1 more source

T‐cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications

Cancer Communications, 2020
T cells, which are involved in adaptive immunity, are essential in the elimination of tumor cells. Mature T cells can specifically recognize the antigen on the major histocompatibility complex (MHC) molecule through T‐cell receptors (TCR).
Na Li, Jiani Yuan, Wenjia Tian, Lin Meng, Yongyu Liu   +4 more
doaj   +1 more source

Enterovirus 71 Infection Shapes Host T Cell Receptor Repertoire and Presumably Expands VP1-Specific TCRβ CDR3 Cluster

Pathogens, 2020
Enterovirus 71 (EV71) has become an important public health problem in the Asia-Pacific region in the past decades. EV71 infection might cause neurological and psychiatric complications and even death. Although an EV71 vaccine has been currently approved,
Yu-Wen Liao, Bing-Ching Ho, Min-Hsuan Chen, Sung-Liang Yu   +3 more
doaj   +1 more source

Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity. [PDF]

PLoS ONE, 2012
BACKGROUND: The importance of CD4⁺ and CD8⁺ T cells in protection against tuberculosis (TB) is well known, however, the association between changes to the T cell repertoire and disease presentation has never been analyzed.
Wei Luo, Jin Su, Xiao-Bing Zhang, Zhi Yang, Ming-Qian Zhou, Zhen-Min Jiang, Pei-Pei Hao, Su-Dong Liu, Qian Wen, Qi Jin, Li Ma   +10 more
doaj   +1 more source