Results 21 to 30 of about 30,633 (227)
Huge Overlap of Individual TCR Beta Repertoires [PDF]
Frontiers in Immunology, 2013 It has been reported that human TCR repertoires commonly carry so-called public clonotypes – CDR3 variants that are often shared between individuals. Cross-comparison of individual immune repertoires has previously revealed the existence of a population of TCR beta CDR3 variants that are identical at the amino acid level for any two donors (1–3).
Mikhail eShugay +7 more
openaire +3 more sources
Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis
Frontiers in Immunology, 2022 CD8+ T cells are the key effector cells that contribute to the antitumor immune response. They comprise various T-cell clones with diverse antigen-specific T-cell receptors (TCRs).
Hiroyasu Aoki +4 more
doaj +1 more source
Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
Frontiers in Immunology, 2020 Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the ...
Meriem Attaf +26 more
doaj +1 more source
Cancer Communications, 2020 T cells, which are involved in adaptive immunity, are essential in the elimination of tumor cells. Mature T cells can specifically recognize the antigen on the major histocompatibility complex (MHC) molecule through T‐cell receptors (TCR).
Na Li +4 more
doaj +1 more source
Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity. [PDF]
PLoS ONE, 2012 BACKGROUND: The importance of CD4⁺ and CD8⁺ T cells in protection against tuberculosis (TB) is well known, however, the association between changes to the T cell repertoire and disease presentation has never been analyzed.
Wei Luo +10 more
doaj +1 more source
The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation
Iranian Journal of Allergy, Asthma and Immunology, 2022 Immune reconstitution after hematopoietic stem cell transplantation (HSCT) with a conditioning regimen has appeared to be a promising treatment for autoimmune diseases and hematologic malignancies.
Fahimeh Zamani +8 more
doaj +1 more source
Pathogens, 2020 Enterovirus 71 (EV71) has become an important public health problem in the Asia-Pacific region in the past decades. EV71 infection might cause neurological and psychiatric complications and even death. Although an EV71 vaccine has been currently approved,
Yu-Wen Liao +3 more
doaj +1 more source
The TCR δ Repertoire in Normal Human Skin is Restricted and Distinct from the TCR δ Repertoire in the Peripheral Blood [PDF]
Journal of Investigative Dermatology, 2001 The skin and the intestinal mucosa form surfaces to external environments and share similarities in anatomic structure and immunologic defense. In healthy humans, intestinal gamma/delta T cells express a highly restricted gamma/delta T cell receptor repertoire whereas gamma/delta T cells of the skin were thought to express a polyclonal repertoire ...
Holtmeier, Wolfgang +5 more
openaire +2 more sources
Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice [PDF]
The Journal of Immunology, 2016 Abstract Currently, there is little consensus regarding the most appropriate animal model to study acute infection and the virus-specific CD8+ T cell (CTL) responses in neonates. TCRβ high-throughput sequencing in naive CTL of differently aged neonatal mice was performed, which demonstrated differential Vβ family gene usage.
Alison J Carey +9 more
openaire +2 more sources
The Journal of Clinical Investigation, 2022 A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age.
Xiaoping Sun +17 more
doaj +1 more source