Results 11 to 20 of about 30,633 (227)

TCR repertoire dynamics and their responses underscores dengue severity. [PDF]

iScience
Despite recognizing the immune response's role in dengue progression, the intricate dynamics of T cell receptor (TCR) variations across DENV infection severities remain elusive. This study addresses this gap by analyzing in-house generated RNA-seq data from 112 dengue patients with varying disease severities.
Khare K, Yadav S, Tarai B, Budhiraja S, Pandey R.   +4 more
europepmc   +4 more sources

Quantifiable blood TCR repertoire components associate with immune aging. [PDF]

Nat Commun
Abstract T cell senescence results in decayed adaptive immune protection in older individuals, with decreased or increased abundance of certain T cell phenotypic subpopulations. However, no study has linked aging to the dynamic changes of T cell clones.
Hu J, Pan M, Reid B, Tworoger S, Li B.
europepmc   +4 more sources

Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire [PDF]

iScience
Summary: HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their T cell receptor (TCR) are termed donor-unrestricted T cells due to restricted allelic ...
Linda Voogd, Anne M.H.F. Drittij, Calinda K.E. Dingenouts, Kees L.M.C. Franken, Vincent van Unen, Krista E. van Meijgaarden, Paula Ruibal, Renate S. Hagedoorn, Judith A. Leitner, Peter Steinberger, Mirjam H.M. Heemskerk, Mark M. Davis, Thomas J. Scriba, Tom H.M. Ottenhoff, Simone A. Joosten   +14 more
doaj   +2 more sources

Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions [PDF]

Seminars in Immunology, 2023
Nan-Ping Weng
exaly   +2 more sources

Proportional Tumor Infiltration of T Cells via Circulation Duplicates the T Cell Receptor Repertoire in a Bilateral Tumor Mouse Model

Frontiers in Immunology, 2021
Temporal analysis of the T cell receptor (TCR) repertoire has been used to monitor treatment-induced changes in antigen-specific T cells in patients with cancer.
Mikiya Tsunoda, Mikiya Tsunoda, Hiroyasu Aoki, Hiroyasu Aoki, Haruka Shimizu, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha   +7 more
doaj   +1 more source

Quantifying Distribution of Flow Cytometric TCR-Vβ Usage with Economic Statistics. [PDF]

PLoS ONE, 2015
Measuring changes of the T cell receptor (TCR) repertoire is important to many fields of medicine. Flow cytometry is a popular technique to study the TCR repertoire, as it quickly provides insight into the TCR-Vβ usage among well-defined populations of T
Kornelis S M van der Geest, Wayel H Abdulahad, Gerda Horst, Pedro G Lorencetti, Johan Bijzet, Suzanne Arends, Marieke van der Heiden, Anne-Marie Buisman, Bart-Jan Kroesen, Elisabeth Brouwer, Annemieke M H Boots   +10 more
doaj   +1 more source

T-Cell Receptor Repertoire as a Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma

Current Issues in Molecular Biology, 2023
Immune checkpoint inhibitors (ICIs) are effective in treating renal cell carcinoma (RCC) but can also cause immune-related adverse events (irAEs). The relationship between irAEs and the T-cell receptor (TCR) repertoire in RCC patients treated with ICIs ...
Takuro Kobayashi, Masayoshi Nagata, Yoshihiro Ikehata, Yuki Nagashima, Naoya Nagaya, Yan Lu, Shigeo Horie   +6 more
doaj   +1 more source

CD4 Promotes Breadth in the TCR Repertoire [PDF]

The Journal of Immunology, 2001
Abstract A diverse population of MHC class II-restricted CD4 lineage T cells develops in mice that lack expression of the CD4 molecule. In this study, we show that the TCR repertoire selected in the absence of CD4 is distinct, but still overlapping in its properties with that selected in the presence of CD4.
Q, Wang, L, Malherbe, D, Zhang, K, Zingler, N, Glaichenhaus, N, Killeen   +5 more
openaire   +2 more sources

TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes

BMC Bioinformatics, 2022
Background T cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to examine the T cell receptor (TCR) repertoire at the individual sequence level.
Meiling Liu, Juna Goo, Yang Liu, Wei Sun, Michael C. Wu, Li Hsu, Qianchuan He   +6 more
doaj   +1 more source

Human γδ TCR Repertoires in Health and Disease [PDF]

Cells, 2020
The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ
Alina Suzann Fichtner, Sarina Ravens, Immo Prinz   +2 more
openaire   +3 more sources