Results 11 to 20 of about 206,427 (253)

Human TCR repertoire in cancer [PDF]

Cancer Medicine
Background T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses.
Lin Chen, Yuan Hu, Bohao Zheng, Limei Luo, Zhenzhen Su   +4 more
doaj   +5 more sources

TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs [PDF]

Cell Reports Methods, 2023
T cell receptor (TCR) technologies, including repertoire analyses and T cell engineering, are increasingly important in the clinical management of cellular immunity in cancer, transplantation, and other immune diseases. However, sensitive and reliable methods for repertoire analyses and TCR cloning are still lacking.
Raphael Genolet, Patrick Reichenbach, Alexandra Michel   +2 more
exaly   +4 more sources

Circulating gluten-specific, but not CMV-specific, CD39+ regulatory T cells have an oligoclonal TCR repertoire [PDF]

Clinical and Translational Immunology, 2020
Objectives Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T‐cell (Treg) populations is important for strategies aiming to re‐establish tolerance in autoimmune diseases. We studied circulating deamidated gluten‐epitope‐specific CD39+
Jason Tye-din, Anthony Kelleher, Nabila Seddiki   +2 more
exaly   +5 more sources

Machine Learning Approaches to TCR Repertoire Analysis. [PDF]

Front Immunol, 2022
Sparked by the development of genome sequencing technology, the quantity and quality of data handled in immunological research have been changing dramatically. Various data and database platforms are now driving the rapid progress of machine learning for immunological data analysis.
Katayama Y, Yokota R, Akiyama T, Kobayashi TJ.   +3 more
europepmc   +4 more sources

Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice [PDF]

The Journal of Immunology, 2016
Abstract Currently, there is little consensus regarding the most appropriate animal model to study acute infection and the virus-specific CD8+ T cell (CTL) responses in neonates. TCRβ high-throughput sequencing in naive CTL of differently aged neonatal mice was performed, which demonstrated differential Vβ family gene usage.
Alison J Carey, Donald T Gracias, Jillian L Thayer, Alina C Boesteanu, Ogan K Kumova, Yvonne M Mueller, Jennifer L Hope, Joseph A Fraietta, David B H van Zessen, Peter D Katsikis   +9 more
openaire   +3 more sources

Exploiting TCR Repertoire Analysis to Select Therapeutic TCRs for Cancer Immunotherapy. [PDF]

Cells
Over the past decade, numerous innovative immunotherapy strategies have transformed the treatment of cancer and improved the survival of patients unresponsive to conventional chemotherapy and radiation therapy. Immune checkpoint inhibition approaches aim to block negative regulatory pathways that limit the function of endogenous T cells, while adoptive
Demaël UM, Rirkkrai T, Okus FZ, Tiffeau-Mayer A, Stauss HJ.   +4 more
europepmc   +3 more sources

Genetic and environmental determinants of human TCR repertoire diversity [PDF]

Immunity & Ageing, 2020
T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However,
Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati, Timothy A. Chan   +4 more
doaj   +3 more sources

Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR Repertoire [PDF]

The Journal of Immunology, 2011
Abstract Defects in T cell responses against pathogens and reduced diversity of TCRs have been described at both extremes of the life span. Yet, we still lack information on how Ag-specific T cell populations are maintained and/or altered from birth to old age.
Brian D, Rudd, Vanessa, Venturi, Miles P, Davenport, Janko, Nikolich-Zugich   +3 more
openaire   +3 more sources

A comprehensive evaluation of diversity measures for TCR repertoire profiling. [PDF]

BMC Biol
Abstract Background T cells play a crucial role in adaptive immunity, as they monitor internal and external immunogenic signals through their specific receptors (TCRs). Using high-throughput sequencing, one can assess TCR repertoire in various clinical settings and describe it quantitatively by calculating a diversity
Mika J, Polanska A, Blenman KR, Pusztai L, Polanska J, Candéias S, Marczyk M.   +6 more
europepmc   +4 more sources

Exploring the potential of the TCR repertoire as a tumor biomarker (Review). [PDF]

Oncol Lett
T cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T-cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells.
Huang AL, He YZ, Yang Y, Pang M, Zheng GP, Wang HL.   +5 more
europepmc   +3 more sources