Results 11 to 20 of about 34,505 (262)

Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice [PDF]

The Journal of Immunology, 2016
Abstract Currently, there is little consensus regarding the most appropriate animal model to study acute infection and the virus-specific CD8+ T cell (CTL) responses in neonates. TCRβ high-throughput sequencing in naive CTL of differently aged neonatal mice was performed, which demonstrated differential Vβ family gene usage.
Alison J Carey, Donald T Gracias, Jillian L Thayer, Alina C Boesteanu, Ogan K Kumova, Yvonne M Mueller, Jennifer L Hope, Joseph A Fraietta, David B H van Zessen, Peter D Katsikis   +9 more
openaire   +3 more sources

Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR Repertoire [PDF]

The Journal of Immunology, 2011
Abstract Defects in T cell responses against pathogens and reduced diversity of TCRs have been described at both extremes of the life span. Yet, we still lack information on how Ag-specific T cell populations are maintained and/or altered from birth to old age.
Brian D, Rudd, Vanessa, Venturi, Miles P, Davenport, Janko, Nikolich-Zugich   +3 more
openaire   +3 more sources

Genetic and environmental determinants of human TCR repertoire diversity [PDF]

Immunity & Ageing, 2020
T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However,
Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati, Timothy A. Chan   +4 more
doaj   +3 more sources

Designing and Maintaining the Mature TCR Repertoire [PDF]

Immunity, 1999
Peripheral T cell maintenance requires a survival signal delivered upon T cell receptor (TCR)-major histocompatibility complex (MHC) molecule interaction.
Viret, Christophe, Wong, F.Susan, Janeway Jr., Charles A   +2 more
openaire   +2 more sources

Machine Learning Approaches to TCR Repertoire Analysis. [PDF]

Front Immunol, 2022
Sparked by the development of genome sequencing technology, the quantity and quality of data handled in immunological research have been changing dramatically. Various data and database platforms are now driving the rapid progress of machine learning for immunological data analysis.
Katayama Y, Yokota R, Akiyama T, Kobayashi TJ.   +3 more
europepmc   +4 more sources

Exploiting TCR Repertoire Analysis to Select Therapeutic TCRs for Cancer Immunotherapy. [PDF]

Cells
Over the past decade, numerous innovative immunotherapy strategies have transformed the treatment of cancer and improved the survival of patients unresponsive to conventional chemotherapy and radiation therapy. Immune checkpoint inhibition approaches aim to block negative regulatory pathways that limit the function of endogenous T cells, while adoptive
Demaël UM, Rirkkrai T, Okus FZ, Tiffeau-Mayer A, Stauss HJ.   +4 more
europepmc   +3 more sources

Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infants [PDF]

, 2021
Preterm labor (PTL) is the leading cause of neonatal morbidity and mortality worldwide. Whereas many studies have investigated the maternal immune responses that cause PTL, fetal immune cell activation has recently been raised as an important contributor
Nguyen, Quoc-Hung, Nielsen, Sandra Cathrine Abel, Le, Brian L, Le, Brian L., Sper, Renan, Pineda, Silvia, Lee, Ji-Yeun, MacKenzie, Tippi C., Boyd, Scott D, Pineda Sanjuan, Silvia, Boyd, Scott D., Nielsen, Sandra CA, MacKenzie, Tippi C, Sirota, Marina   +13 more
core   +1 more source

Human γδ TCR Repertoires in Health and Disease [PDF]

Cells, 2020
The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ
Alina Suzann Fichtner, Sarina Ravens, Immo Prinz   +2 more
openaire   +3 more sources

CD4 Promotes Breadth in the TCR Repertoire [PDF]

The Journal of Immunology, 2001
Abstract A diverse population of MHC class II-restricted CD4 lineage T cells develops in mice that lack expression of the CD4 molecule. In this study, we show that the TCR repertoire selected in the absence of CD4 is distinct, but still overlapping in its properties with that selected in the presence of CD4.
Q, Wang, L, Malherbe, D, Zhang, K, Zingler, N, Glaichenhaus, N, Killeen   +5 more
openaire   +2 more sources

Huge Overlap of Individual TCR Beta Repertoires [PDF]

Frontiers in Immunology, 2013
It has been reported that human TCR repertoires commonly carry so-called public clonotypes – CDR3 variants that are often shared between individuals. Cross-comparison of individual immune repertoires has previously revealed the existence of a population of TCR beta CDR3 variants that are identical at the amino acid level for any two donors (1–3).
Mikhail eShugay, Dmitriy A Bolotin, Ekaterina V Putintseva, Mikhail V Pogorelyy, Ilgar Z Mamedov, Ilgar Z Mamedov, Dmitriy M Chudakov, Dmitriy M Chudakov   +7 more
openaire   +3 more sources