Results 11 to 20 of about 58,781 (291)

Genetic and environmental determinants of human TCR repertoire diversity [PDF]

Immunity & Ageing, 2020
T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However,
Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati, Timothy A. Chan   +4 more
doaj   +3 more sources

Machine Learning Approaches to TCR Repertoire Analysis. [PDF]

Front Immunol, 2022
Sparked by the development of genome sequencing technology, the quantity and quality of data handled in immunological research have been changing dramatically. Various data and database platforms are now driving the rapid progress of machine learning for immunological data analysis.
Katayama Y, Yokota R, Akiyama T, Kobayashi TJ.   +3 more
europepmc   +4 more sources

Exploiting TCR Repertoire Analysis to Select Therapeutic TCRs for Cancer Immunotherapy. [PDF]

Cells
Over the past decade, numerous innovative immunotherapy strategies have transformed the treatment of cancer and improved the survival of patients unresponsive to conventional chemotherapy and radiation therapy. Immune checkpoint inhibition approaches aim to block negative regulatory pathways that limit the function of endogenous T cells, while adoptive
Demaël UM, Rirkkrai T, Okus FZ, Tiffeau-Mayer A, Stauss HJ.   +4 more
europepmc   +3 more sources

TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing. [PDF]

Nat Methods
Pogorelyy MV, Kirk AM, Adhikari S, Minervina AA, Sundararaman B, Vegesana K, Brice DC, Scott ZB, SJTRC Study Team, Thomas PG.   +9 more
europepmc   +3 more sources

TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance. [PDF]

Inflamm Res, 2023
Zhao J, Jia L, Tao Y, Zhao X, Yang J, Lu Y, Yan Y, Mao L, Hu L, Lu J, Guo M, Chen C, Zhou Y, Wen Z, He Z, Xu L.   +15 more
europepmc   +3 more sources

Proportional Tumor Infiltration of T Cells via Circulation Duplicates the T Cell Receptor Repertoire in a Bilateral Tumor Mouse Model

Frontiers in Immunology, 2021
Temporal analysis of the T cell receptor (TCR) repertoire has been used to monitor treatment-induced changes in antigen-specific T cells in patients with cancer.
Mikiya Tsunoda, Mikiya Tsunoda, Hiroyasu Aoki, Hiroyasu Aoki, Haruka Shimizu, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha   +7 more
doaj   +1 more source

Quantifying Distribution of Flow Cytometric TCR-Vβ Usage with Economic Statistics. [PDF]

PLoS ONE, 2015
Measuring changes of the T cell receptor (TCR) repertoire is important to many fields of medicine. Flow cytometry is a popular technique to study the TCR repertoire, as it quickly provides insight into the TCR-Vβ usage among well-defined populations of T
Kornelis S M van der Geest, Wayel H Abdulahad, Gerda Horst, Pedro G Lorencetti, Johan Bijzet, Suzanne Arends, Marieke van der Heiden, Anne-Marie Buisman, Bart-Jan Kroesen, Elisabeth Brouwer, Annemieke M H Boots   +10 more
doaj   +1 more source

T-Cell Receptor Repertoire as a Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma

Current Issues in Molecular Biology, 2023
Immune checkpoint inhibitors (ICIs) are effective in treating renal cell carcinoma (RCC) but can also cause immune-related adverse events (irAEs). The relationship between irAEs and the T-cell receptor (TCR) repertoire in RCC patients treated with ICIs ...
Takuro Kobayashi, Masayoshi Nagata, Yoshihiro Ikehata, Yuki Nagashima, Naoya Nagaya, Yan Lu, Shigeo Horie   +6 more
doaj   +1 more source

Human γδ TCR Repertoires in Health and Disease [PDF]

Cells, 2020
The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ
Alina Suzann Fichtner, Sarina Ravens, Immo Prinz   +2 more
openaire   +3 more sources

CD4 Promotes Breadth in the TCR Repertoire [PDF]

The Journal of Immunology, 2001
Abstract A diverse population of MHC class II-restricted CD4 lineage T cells develops in mice that lack expression of the CD4 molecule. In this study, we show that the TCR repertoire selected in the absence of CD4 is distinct, but still overlapping in its properties with that selected in the presence of CD4.
Q, Wang, L, Malherbe, D, Zhang, K, Zingler, N, Glaichenhaus, N, Killeen   +5 more
openaire   +2 more sources