Results 51 to 60 of about 206,427 (253)

Studies on the affinity control of T cell development [PDF]

, 2004
Defined interactions between thymocytes and thymic antigen presenting cells ensure that each T cell found in an individual is both self-restricted and self-tolerant.
Naeher, Dieter
core   +1 more source

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E., Heufelder, Armin E., Scriba, Peter C.   +2 more
core   +1 more source

The splenic T cell receptor repertoire during an immune response against a complex antigen: Expanding private clones accumulate in the high and low copy number region.

PLoS ONE, 2022
Large cellular antigens comprise a variety of different epitopes leading to a T cell response of extreme diversity. Therefore, tracking such a response by next generation sequencing of the T cell receptor (TCR) in order to identify common TCR properties ...
Martin Meinhardt, Cornelia Tune, Lisa-Kristin Schierloh, Andrea Schampel, René Pagel, Jürgen Westermann   +5 more
doaj   +1 more source

Characterization of human T cell receptor repertoire data in eight thymus samples and four related blood samples

Data in Brief, 2021
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive ...
Nelli Heikkilä, Iivari Kleino, Reetta Vanhanen, Dawit A. Yohannes, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila   +6 more
doaj   +1 more source

The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse

Scientific Reports, 2021
The self-antigen α-synuclein (α-syn) was recently shown to be associated with Parkinson’s disease (PD). Here we mapped the T cell receptor (TCR) repertoire of α-syn-specific T cells from six PD patients.
Akul Singhania, John Pham, Rekha Dhanwani, April Frazier, Juliana Rezende Dutra, Karen S. Marder, Elizabeth Phillips, Simon Mallal, Amy W. Amara, David G. Standaert, David Sulzer, Bjoern Peters, Alessandro Sette, Cecilia S. Lindestam Arlehamn   +13 more
doaj   +1 more source

Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Frontiers in Immunology, 2021
T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity.
Roberta Amoriello, Alice Mariottini, Clara Ballerini   +2 more
doaj   +1 more source

System-wide Analysis of the T Cell Response

Cell Reports, 2016
The T cell receptor (TCR) controls the cellular adaptive immune response to antigens, but our understanding of TCR repertoire diversity and response to challenge is still incomplete.
Ruxandra Covacu, Hagit Philip, Merja Jaronen, Jorge Almeida, Jessica E. Kenison, Samuel Darko, Chun-Cheih Chao, Gur Yaari, Yoram Louzoun, Liran Carmel, Daniel C. Douek, Sol Efroni, Francisco J. Quintana   +12 more
doaj   +1 more source

Autoencoder based local T cell repertoire density can be used to classify samples and T cell receptors.

PLoS Computational Biology, 2021
Recent advances in T cell repertoire (TCR) sequencing allow for the characterization of repertoire properties, as well as the frequency and sharing of specific TCR. However, there is no efficient measure for the local density of a given TCR.
Shirit Dvorkin, Reut Levi, Yoram Louzoun
doaj   +1 more source

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

ImmunoInformatics, 2022
T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The expression of TCRs is usually measured with targeted sequencing approaches where TCR genes are selectively amplified.
Teresa Rubio, Maria Chernigovskaya, Susanna Marquez, Cristina Marti, Paula Izquierdo-Altarejos, Amparo Urios, Carmina Montoliu, Vicente Felipo, Ana Conesa, Victor Greiff, Sonia Tarazona   +10 more
doaj   +1 more source

A Long-Playing CD about the γδ TCR Repertoire [PDF]

Immunity, 2013
In this issue of Immunity, a study by Luoma et al. (2013) provides structural evidence for direct interactions of human Vδ1(+) T cell receptors with CD1d, capping a long trail of evidence that CD1 might be a major influence on γδ T cell biology.
Hayday, Adrian, Vantourout, Pierre
openaire   +3 more sources