Results 71 to 80 of about 34,505 (262)

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

IMonitor: A Robust Pipeline for TCR and BCR Repertoire Analysis [PDF]

Genetics, 2015
Abstract The advance of next generation sequencing (NGS) techniques provides an unprecedented opportunity to probe the enormous diversity of the immune repertoire by deep sequencing T-cell receptors (TCRs) and B-cell receptors (BCRs). However, an efficient and accurate analytical tool is still on demand to process the huge amount of data.
Zhang, Wei, Du, Yuanping, Su, Zheng, Wang, Changxi, Zeng, Xiaojing, Zhang, Ruifang, Hong, Xueyu, Nie, Chao, Wu, Jinghua, Cao, Hongzhi, Xu, Xun, Liu, Xiaoli   +11 more
openaire   +3 more sources

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Peripheral Blood TCR Clonotype Diversity as a Biomarker for Colorectal Cancer

Bioengineering
There exists an urgent need to improve colorectal cancer (CRC) diagnosis due to limitations in current diagnostic approaches. Systematic characterization of the human T cell receptor (TCR) repertoire, coupled with advanced computational methods, provides
Gaochen Zhu, Tao Chen, Chen Ma, Kai Liu, Bihui Huang, Guan Yang   +5 more
doaj   +1 more source

TCR Repertoire diversity estimation.

, 2019
Boxplot of chao1 estimator for normalised samples were used to assess the diversity of TCR repertoire in cases and control. PBMC: total blood cells. FACs: Sorting for Treg cells by FACs analysis.
Alfredo Rossi (564968), Andrew G. Messenger (256618), Andrew J. G. McDonagh (5461652), Afsaneh Maleki-Dizaji (6920528), Fatma N. Hamed (6920522), Marta Bertolini (564966), Annika Åstrand (6920525), Rachid Tazi-Ahnini (739676)   +7 more
core   +1 more source

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology
Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases.
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
doaj   +1 more source

CD4 Gag-reactive TCR repertoire files

, 2019
CD4 Gag-reactive TCR ...
Mark Pilkinton (6613034)
core   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Evaluating the utility of amino acid similarity-aware kmers to represent TCR repertoires for classification.

PLoS Computational Biology
Insights gained through interpretation of models trained on the T-cell receptor (TCR) repertoire contribute to advances in understanding of immune-mediated disease.
Hannah Kockelbergh, Shelley C Evans, Liam Brierley, Peter L Green, Andrea L Jorgensen, Elizabeth J Soilleux, Anna Fowler   +6 more
doaj   +1 more source