Results 81 to 90 of about 34,505 (262)

Novel NHEJ1 pathogenic variant linked to severe combined immunodeficiency, microcephaly, and abnormal T and B cell receptor repertoires

Frontiers in Pediatrics, 2022
BackgroundDuring the process of generating diverse T and B cell receptor (TCR and BCR, respectively) repertoires, double-strand DNA breaks are produced.
Shirly Frizinsky, Shirly Frizinsky, Erez Rechavi, Erez Rechavi, Ortal Barel, Yu Nee Lee, Yu Nee Lee, Amos J. Simon, Amos J. Simon, Atar Lev, Atar Lev, Tali Stauber, Tali Stauber, Tali Stauber, Etai Adam, Raz Somech, Raz Somech, Raz Somech   +17 more
doaj   +1 more source

CD8 Gag-reactive TCR repertoire file

, 2019
CD8 Gag-reactive TCR repertoire for all ...
Mark Pilkinton (6613034)
core   +1 more source

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

The TCR Repertoire of an Immunodominant CD8+ T Lymphocyte Population [PDF]

The Journal of Immunology, 2001
Abstract The TCR repertoire of an epitope-specific CD8+ T cell population remains poorly characterized. To determine the breadth of the TCR repertoire of a CD8+ T cell population that recognizes a dominant epitope of the AIDS virus, the CD8+ T cells recognizing the tetrameric Mamu-A*01/p11C,CM complex were isolated from simian ...
Z W, Chen, Y, Li, X, Zeng, M J, Kuroda, J E, Schmitz, Y, Shen, X, Lai, L, Shen, N L, Letvin   +8 more
openaire   +2 more sources

Integrating Immunotherapy Into Head and Neck Surgery: Bridging Tumor Biology to Perioperative Decision‐Making, a Review

Head &Neck, EarlyView.
ABSTRACT Objective To provide a comprehensive review of the biological rationale, clinical evidence, and practical perioperative management of immunotherapy for the head and neck surgeon. Summary Background Data Standard treatment for resectable head and neck squamous cell carcinoma (HNSCC) has reached a survival plateau, with over 50% of patients ...
Nicholas Brian Shannon, Bruce Ashford
wiley   +1 more source

Revealing individual signatures of human T cell CDR3 sequence repertoires with Kidera Factors.

PLoS ONE, 2014
The recent development of High Throughput Sequencing technologies has enabled an individual's TCR repertoire to be efficiently analysed at the nucleotide level. However, with unique clonotypes ranging in the tens of millions per individual, this approach
Michael Epstein, Martino Barenco, Nigel Klein, Michael Hubank, Robin E Callard   +4 more
doaj   +1 more source

Disease etiology and diagnosis by TCR repertoire analysis goes viral

, 2016
The importance of T-cell receptor (TCR) repertoire diversity is highlighted in murine models of immunodeficiency and in many human pathologies. However, the true extent of TCR diversity and how this diversity varies in health and disease is poorly ...
Attaf, Meriem, Sewell, Andrew K.
core   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Comprehensive analysis of TCR-beta repertoire in patients with neurological immune-mediated disorders [PDF]

, 2018
In this study we characterized the TCR repertoire profiles in patients with chronic progressive inflammatory neurological disorders including HAM/TSP, associated with human T-cell lymphotropic virus type I (HTLV-I) infection, and multiple sclerosis (MS),
Johnson, Kory R, Steven Jacobson, Ohayon, Joan, Paolo A. Muraro, Sousa, Alessandra de Paula Alves, Jun Zhu, Alessandra de Paula Alves Sousa, Zhu, Jun, Jacobson, Steven, Kory R. Johnson, Muraro, Paolo A, Joan Ohayon   +11 more
core   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source