Results 61 to 70 of about 206,427 (253)

Individual Epitope-Specific CD8⁺ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection

Pathogens, 2023
A hallmark in chronic viral infections are exhausted antigen-specific CD8+ T cell responses and the inability of the immune system to eliminate the virus.
Sebastian Klein, Jasmin Mischke, Finn Beruldsen, Immo Prinz, Dinler A. Antunes, Markus Cornberg, Anke R. M. Kraft   +6 more
doaj   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8+ T Cell Subsets

Frontiers in Immunology, 2017
A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cell ...
Ling Huang, Michiel G. H. Betjes, Mariska Klepper, Anton W. Langerak, Carla C. Baan, Nicolle H. R. Litjens   +5 more
doaj   +1 more source

Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus. [PDF]

, 2007
Expression of TCRbeta and pre-TCR signalling are essential for differentiation of CD4- CD8- double negative (DN) thymocytes to the CD4+ CD8+ double-positive (DP) stage.
Outram, Susan V, Dessens, Johannes T, Nicola J. Rowbotham, Rowbotham, Nicola J, Tessa Crompton, Hager-Theodorides, Ariadne L, Ariadne L. Hager‐Theodorides, Susan V. Outram, Crompton, Tessa, Johannes T. Dessens   +9 more
core   +1 more source

A novel signature for stratifying the molecular heterogeneity of the tissue-infiltrating T-cell receptor repertoire reflects gastric cancer prognosis

Scientific Reports, 2017
Many basic properties of the T-cell receptor (TCR) repertoire require clarification, and the changes occurring in the TCR repertoire during carcinogenesis, especially during precancerous stages, remain unclear. This study used deep sequencing analyses to
Manchao Kuang, Jieyao Cheng, Chengli Zhang, Lin Feng, Xue Xu, Yajing Zhang, Ming Zu, Jianfang Cui, Hang Yu, Kaitai Zhang, Aiming Yang, Shujun Cheng   +11 more
doaj   +1 more source

Diversification of the TCR β Locus Vβ Repertoire by CTCF [PDF]

ImmunoHorizons, 2018
Abstract The architectural protein CTCF regulates the conformation and recombination of Ag receptor loci. To study the importance of CTCF in Tcrb locus repertoire formation, we created a conditional knockout mouse line that deletes Ctcf early during thymocyte development.
Shiwei Chen, Michael S Krangel
openaire   +2 more sources

Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients

Journal of Translational Medicine, 2010
Several immunotherapeutic approaches rely on antigen-specific T-cells. Restrictions in the T-cell receptor (TCR) repertoire were reported as indicator of anti-tumor cytotoxic T-lymphocyte (CTL) response in various tumor entities.
Thiel Eckhard, Nüssler Natascha C, Busse Antonia, Wojtke Susanne, Fusi Alberto, Ochsenreither Sebastian, Keilholz Ulrich, Nagorsen Dirk   +7 more
doaj   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation [PDF]

, 2007
TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E, Rowbotham, NJ, Crompton, T, Dyson, J, Shah, DK, Cebecauer, M, Hager-Theodorides, AL, Outram, SV   +7 more
core  

The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma

Journal of Translational Medicine
Background Esophageal squamous cell carcinoma (ESCC) is a malignant neoplasm with detrimental implications for human health. The landscape of ESCC therapy has been revolutionized by the introduction of immunotherapy, specifically involving immune ...
Meng Yang, Dan He, Yu Sun, Yunquan Guo, Yu Ma, Lin Feng, Meng Liu   +6 more
doaj   +1 more source