Results 61 to 70 of about 58,781 (291)
MAIT cells come to the rescue in cancer immunotherapy? [PDF]
, 2020 Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk +2 more
core +2 more sources
Diversification of the TCR β Locus Vβ Repertoire by CTCF [PDF]
ImmunoHorizons, 2018 Abstract The architectural protein CTCF regulates the conformation and recombination of Ag receptor loci. To study the importance of CTCF in Tcrb locus repertoire formation, we created a conditional knockout mouse line that deletes Ctcf early during thymocyte development.
Shiwei Chen, Michael S Krangel
openaire +2 more sources
Journal of Translational Medicine, 2010 Several immunotherapeutic approaches rely on antigen-specific T-cells. Restrictions in the T-cell receptor (TCR) repertoire were reported as indicator of anti-tumor cytotoxic T-lymphocyte (CTL) response in various tumor entities.
Thiel Eckhard +7 more
doaj +1 more source
The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes
eLife, 2020 The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative sequencing
Peter C de Greef +7 more
doaj +1 more source
Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage. [PDF]
PLoS ONE, 2012 Islet transplantation provides a "cure" for type 1 diabetes but is limited in part by recurrent autoimmunity mediated by β cell-specific CD4(+) and CD8(+) T cells.
Ramiro Diz +6 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang +13 more
wiley +1 more source
The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma
Journal of Translational MedicineBackground Esophageal squamous cell carcinoma (ESCC) is a malignant neoplasm with detrimental implications for human health. The landscape of ESCC therapy has been revolutionized by the introduction of immunotherapy, specifically involving immune ...
Meng Yang +6 more
doaj +1 more source
Frontiers in Immunology, 2015 T cell immunity relies on the generation and maintenance of a diverse repertoire of T cell antigen receptors (TCRs). The strength of signaling emanating from the TCR dictates the fate of T cells during development, as well as during the immune response ...
Julia eMerkenschlager, George eKassiotis
doaj +1 more source
A new homeostatic model of the T cell system
, 2010 Our main tenet argues that the primary role of positive thymic selection and the resulting T cell population is the maintenance of a homeostatic equilibrium with self MHC-self peptide complexes.
Bakacs, Tibor, Szabados, Tamas
core +1 more source
Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]
, 2013 It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren +3 more
core +1 more source