Results 61 to 70 of about 34,505 (262)

Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage. [PDF]

PLoS ONE, 2012
Islet transplantation provides a "cure" for type 1 diabetes but is limited in part by recurrent autoimmunity mediated by β cell-specific CD4(+) and CD8(+) T cells.
Ramiro Diz, Alaina Garland, Benjamin G Vincent, Mark C Johnson, Nicholas Spidale, Bo Wang, Roland Tisch   +6 more
doaj   +1 more source

The partitioning of TCR repertoires by thymic selection

Journal of Experimental Medicine
αβ T cells are critical components of the adaptive immune system; they maintain tissue and immune homeostasis during health, provide sterilizing immunity after pathogen infection, and are capable of eliminating transformed tumor cells. Fundamental to these distinct functions is the ligand specificity of the unique antigen receptor expressed on each ...
Wan-Lin Lo, Eric S. Huseby
openaire   +2 more sources

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Narrowing the gap: preserving repertoire diversity despite clonal selection during the CD4 T cell response

Frontiers in Immunology, 2015
T cell immunity relies on the generation and maintenance of a diverse repertoire of T cell antigen receptors (TCRs). The strength of signaling emanating from the TCR dictates the fate of T cells during development, as well as during the immune response ...
Julia eMerkenschlager, George eKassiotis
doaj   +1 more source

CDR3 Spectratyping Analysis of the TCR Repertoire in Myasthenia Gravis [PDF]

The Journal of Immunology, 2006
Abstract Because myasthenia gravis (MG) is an autoimmune disease mediated by Abs specific for the acetylcholine receptor, helper T cells play a role in Ab production. In this study, we have performed large-scale cross-sectional and longitudinal TCR studies by CDR3 spectratyping using PBL and thymus tissues from MG patients.
Yoh, Matsumoto, Hidenori, Matsuo, Hiroshi, Sakuma, Il-Kwon, Park, Yukiko, Tsukada, Kuniko, Kohyama, Takayuki, Kondo, Satoshi, Kotorii, Noritoshi, Shibuya   +8 more
openaire   +2 more sources

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

HIV infection and ART exposure affect tumor TCR repertoire of diffuse large B cell lymphoma. [PDF]

JCI Insight
The most common subtype of lymphoma globally, diffuse large B cell lymphoma (DLBCL), is a leading cause of cancer death in people with HIV. The restructuring of the T cell compartment because of HIV infection and antiretroviral therapy (ART) may have ...
Roush SM, Coelho J, Xu AM, Puranam K, Mponda M, Kasonkanji E, Mulenga M, Tomoka T, Galeotti J, Brownlee A, Ghadially H, Chagomerana M, Damania B, Painschab M, Merchant A, Gopal S, Fedoriw Y.   +16 more
europepmc   +2 more sources

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates

Frontiers in Immunology, 2017
Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported that neonatal mice have a rapidly evolving T-cell receptor (TCR) repertoire that impairs CD8+ T
Alison J. Carey, Alison J. Carey, Jennifer L. Hope, Jennifer L. Hope, Yvonne M. Mueller, Adam J. Fike, Ogan K. Kumova, David B. H. van Zessen, David B. H. van Zessen, Eric A. P. Steegers, Mirjam van der Burg, Peter D. Katsikis   +11 more
doaj   +1 more source

Reduced diversity of intestinal T-cell receptor repertoire in patients with Crohn’s disease

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundThe intestinal microenvironment directly determines the human T-cell receptor (TCR) repertoire. Despite its extreme diversity, TCR repertoire analysis may provide a better understanding of the immune system in patients with inflammatory bowel ...
Sung Noh Hong, Sung Noh Hong, Joo-Young Park, So-Yun Yang, Chansu Lee, Chansu Lee, Young-Ho Kim, Je-Gun Joung   +7 more
doaj   +1 more source