Analysis of CDR3 Sequences from T-Cell Receptor β in Acute Respiratory Distress Syndrome
Biomolecules, 2023 Acute Respiratory Distress Syndrome (ARDS) is an illness that typically develops in people who are significantly ill or have serious injuries. ARDS is characterized by fluid build-up that occurs in the alveoli. T-cells are implicated as playing a role in
Sara Hey +8 more
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High-throughput profiling of the T cell receptor delta CDR3 repertoire reveals species-specific patterns in cattle (Bos taurus) and water buffalo (Bubalus bubalis) [PDF]
Frontiers in ImmunologyBackgroundγδ T cells constitute a substantial proportion of lymphocytes in ruminants, and the diversity of their immune receptors is critical for understanding species-specific immune functions.
Yueheng Zhang +5 more
doaj +2 more sources
Annotation of bat IG H/L/K loci and analysis of the characteristics of bat BCR-CDR3 repertoires [PDF]
Frontiers in ImmunologyBats represent the second largest order of mammals and are the only flying mammals, exhibiting remarkable biological characteristics such as viral tolerance, longevity, and low tumor incidence.
QinLu Liu +7 more
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Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing
Cellular Physiology and Biochemistry, 2016 Background/Aims: To ward off a wide variety of pathogens, the human adaptive immune system harbors a vast array of T-cell receptors, collectively referred to as the TCR repertoire.
Xianliang Hou +8 more
doaj +2 more sources
Comparative analysis of CDR3 regions in paired human αβ CD8 T cells
FEBS Open Bio, 2019 The majority of human CD8 cytotoxic T lymphocytes express αβ T‐cell receptors that recognize peptide–MHC class I complexes. Considerable attention has been devoted to TCR β repertoires, but study of TCR α chains has been limited.
Dan Lu, Qiong Yang
exaly +2 more sources
An Aging Clock Based on Immune Repertoire Features: COVID-19 Accelerates Aging. [PDF]
Aging CellWe systematically profiled TCR/BCR repertoires in Chinese individuals and paired COVID‐19 samples, revealed aging‐driven remodeling and COVID‐accelerated immune senescence, and built a reliable immune repertoire aging clock for immune senescence evaluation.
Gao X +13 more
europepmc +2 more sources
T-Cell Receptor CDR3 Loop Conformations in Solution Shift the Relative Vα-Vβ Domain Distributions
Frontiers in Immunology, 2020 T-cell receptors are an important part in the adaptive immune system as they are responsible for detecting foreign proteins presented by the major histocompatibility complex (MHC). The affinity is predominantly determined by structure and sequence of the
Mónica L Fernández-Quintero +2 more
exaly +3 more sources
Comparative analysis of CDR3 length-dependent patterns in VHHs
Frontiers in ImmunologyIntroductionVHHs, or nanobodies, are distinguished by their compact size, high stability, and unique ability to selectively target specific epitopes. The CDR3 region in VHHs, which plays a crucial role in antigen binding, exhibits significant diversity ...
Lu Zhang +7 more
doaj +4 more sources
CDR3 sequences in IgA nephropathy are shorter and exhibit reduced diversity [PDF]
FEBS Open Bio, 2020 Immunoglobulin (Ig) A nephropathy (IgAN) is the most common glomerulonephritis, which is characterized by the deposition of IgA antibody in the glomerulus. Systematic dissection of immune composition may contribute to a better understanding of the alternations in the immune system in IgAN.
Xi Zhang +6 more
openaire +3 more sources
Analysis of CDR3 region diversity with different lengths in bovine immunoglobulin heavy chain genes [PDF]
Frontiers in ImmunologyIntroductionCattle produce a unique antibody repertoire characterized by an exceptionally wide range of complementarity determining region 3 heavy chain (CDR3H) lengths, spanning from 1 bp to 204 bp—a feature that is extremely rare among mammals.
Haidong Zhao +5 more
doaj +2 more sources