Results 21 to 30 of about 19,601 (224)

Developmental Changes in the Human Heavy Chain CDR3 [PDF]

The Journal of Immunology, 2005
Abstract The CDR3 of the Ig H chain (CDR3H) is significantly different in fetal and adult repertoires. To understand the mechanisms involved in the developmental changes in the CDR3H of Ig H chains, sets of nonproductive VHDJH rearrangements obtained from fetal, full-term neonates and adult single B cells were analyzed and compared ...
M Margarida, Souto-Carneiro, Gary P, Sims, Hermann, Girschik, Jisoo, Lee, Peter E, Lipsky   +4 more
openaire   +2 more sources

Enterovirus 71 Infection Shapes Host T Cell Receptor Repertoire and Presumably Expands VP1-Specific TCRβ CDR3 Cluster

Pathogens, 2020
Enterovirus 71 (EV71) has become an important public health problem in the Asia-Pacific region in the past decades. EV71 infection might cause neurological and psychiatric complications and even death. Although an EV71 vaccine has been currently approved,
Yu-Wen Liao, Bing-Ching Ho, Min-Hsuan Chen, Sung-Liang Yu   +3 more
doaj   +1 more source

Characteristics Peripheral Blood IgG and IgM Heavy Chain Complementarity Determining Region 3 Repertoire before and after Immunization with Recombinant HBV Vaccine. [PDF]

PLoS ONE, 2017
Immunization with recombinant HBV vaccine induces specific immune responses in human causing B lymphocytes to produce protective HBsAb, and to form memory B lymphocytes, thereby facilitating HBV immunity in the body.
Long Ma, Xiaomei Wang, Xiaoying Bi, Jiezuan Yang, Bin Shi, Xiaoyan He, Rui Ma, Qingqing Ma, Xinsheng Yao   +8 more
doaj   +1 more source

CDR3 length distribution.

, 2021
CDR3 length distribution in the full dataset of 276993 sequences from Ref. [16]. (PDF)
Aleksandra M. Walczak (7252508), Barbara Bravi (8520324), Simona Cocco (449128), Thierry Mora (369624), Vinod P. Balachandran (5565923), Rémi Monasson (3170655), Benjamin D. Greenbaum (11379038)   +6 more
core   +1 more source

CDR3 Spectratyping Analysis of the TCR Repertoire in Myasthenia Gravis [PDF]

The Journal of Immunology, 2006
Abstract Because myasthenia gravis (MG) is an autoimmune disease mediated by Abs specific for the acetylcholine receptor, helper T cells play a role in Ab production. In this study, we have performed large-scale cross-sectional and longitudinal TCR studies by CDR3 spectratyping using PBL and thymus tissues from MG patients.
Yoh, Matsumoto, Hidenori, Matsuo, Hiroshi, Sakuma, Il-Kwon, Park, Yukiko, Tsukada, Kuniko, Kohyama, Takayuki, Kondo, Satoshi, Kotorii, Noritoshi, Shibuya   +8 more
openaire   +2 more sources

CDR3 high-throughput sequencing data

, 2023
 Clone frequencies of CDR3 sequences in the T cells derived from the lymph nodes of mice with indicated treatments. 
Jiaqi Meng (16483371)
core   +1 more source

Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALB/c Mice

Journal of Immunology Research, 2020
To study the homogeneity and heterogeneity of CD4+CD25+ T cells receptor β-chain complementarity determining region 3 (TCR β CDR3) repertoires in breast tumor tissues, lung metastatic tissues, and spleens from 4T1 tumor-bearing BALB/c mice.
Teng Zhang, Fangfang Duan, Danhua Su, Long Ma, Jiezuan Yang, Bin Shi, Xiaoyan He, Rui Ma, Suhong Sun, Xinsheng Yao   +9 more
doaj   +1 more source

Dynamic analysis of peripheral blood TCR β-chain CDR3 repertoire in occupational medicamentosa-like dermatitis due to trichloroethylene

Scientific Reports, 2021
Previously, we had cross-sectionally explored the characteristics of T cell receptor (TCR) repertoires from occupational medicamentosa-like dermatitis due to trichloroethylene (OMDT) patients, now we further analyzed the dynamic features of OMDT TCR ...
Dafeng Lin, Dianpeng Wang, Peimao Li, Xiangli Yang, Wei Liu, Lu Huang, Zhimin Zhang, Yanfang Zhang, Wen Zhang, Naixing Zhang, Ming Zhang, Xianqing Huang   +11 more
doaj   +1 more source

Profiling the peripheral blood T cell receptor repertoires of gastric cancer patients

Frontiers in Immunology, 2022
Cancer driven by somatic mutations may express neoantigens that can trigger T-cell immune responses. Since T-cell receptor (TCR) repertoires play critical roles in anti-tumor immune responses for oncology, next-generation sequencing (NGS) was used to ...
Mengyao Wang, Peng Gao, Laifeng Ren, Jingjing Duan, Silu Yang, Haina Wang, Hongxia Wang, Junning Sun, Xiaoyan Gao, Bo Li, Shuaicheng Li, Wen Su   +11 more
doaj   +1 more source

CDR3 length in antigen-specific immune receptors. [PDF]

The Journal of experimental medicine, 1994
In both immunoglobulins (Ig) and T cell receptors (TCR), the rearrangement of V, D, and J region sequence elements during lymphocyte maturation creates an enormous degree of diversity in an area referred to as the complementarity determining region 3 (CDR3) loop.
E P, Rock, P R, Sibbald, M M, Davis, Y H, Chien   +3 more
openaire   +2 more sources