Results 1 to 10 of about 2,912,674 (304)
Regulation of B cell fate by chronic activity of the IgE B cell receptor [PDF]
eLife, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Zhiyong Yang +6 more
doaj +3 more sources
Is the vaccination-induced B cell receptor repertoire predictable? [PDF]
ImmunoInformaticsVaccines trigger an immune response that results in a population of memory cells that can quickly respond to subsequent antigen re-encounters. Most vaccines are designed to induce memory B cells with vaccine-specific B cell receptors (BCRs).
Eve Richardson +4 more
doaj +2 more sources
Unique chicken B cell development: species-specific mechanisms and contradictory requirements of B cell receptor for post-hatched B cell development [PDF]
Frontiers in ImmunologyChicken B cell development represents a remarkable evolutionary divergence from mammalian paradigms, featuring unique three-stage ontogeny centered on the bursa of Fabricius, an avian-specific primary B cell lymphoid organ.
Seung Je Woo +2 more
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T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis [PDF]
Frontiers in ImmunologyBackgroundTuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB).
Fengjiao Du +12 more
doaj +2 more sources
B cell receptor repertoire abnormalities in autoimmune disease [PDF]
Frontiers in ImmunologyB cells play a crucial role in the immune response and contribute to various autoimmune diseases. Recent studies have revealed abnormalities in the B cell receptor (BCR) repertoire of patients with autoimmune diseases, with distinct features observed ...
Hayato Yuuki +7 more
doaj +2 more sources
B cell receptor dependent enhancement of dengue virus infection. [PDF]
PLoS PathogensDengue virus (DENV) is the causative agent of dengue, a mosquito-borne disease that represents a significant and growing public health burden around the world.
Chad Gebo +12 more
doaj +2 more sources
Aberrant B Cell Signaling in Autoimmune Diseases
Cells, 2022 Aberrant B cell signaling plays a critical in role in various systemic and organ-specific autoimmune diseases. This is supported by genetic evidence by many functional studies in B cells from patients or specific animal models and by the observed ...
Odilia B. J. Corneth +2 more
doaj +1 more source
Immunoglobulin M-degrading enzyme of Streptococcus suis (IdeSsuis) impairs porcine B cell signaling
Frontiers in Immunology, 2023 Streptococcus suis (S. suis) is an important porcine pathogen, causing severe disease like meningitis and septicemia primarily in piglets. Previous work showed that the IgM-degrading enzyme of S.
Annika Katharina Breitfelder +6 more
doaj +1 more source
Revising B Cell Receptors [PDF]
The Journal of Experimental Medicine, 2000 B cell development is often portrayed as a series of decision points that expand an antigen-reactive cell to a clone producing a single antibody. This is hardly the case: B cell development is dependent on a series of error-prone, random rearrangement events that through ongoing ...
D, Nemazee, M, Weigert
openaire +2 more sources
Human Vaccines & Immunotherapeutics, 2021 The Hepatitis B (HB) vaccine is efficacious in preventing hepatitis B virus infection. However, the association between antibody response to the HB vaccine and dynamic immune repertoire changes in different cell subsets remains unclear.
Miaoxian Zhao +8 more
doaj +1 more source