Results 1 to 10 of about 9,437,655 (307)

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation [PDF]

open access: yesNature Communications, 2017
Activated B cells differentiate into antibody-producing plasma cells in the germinal centre in secondary lymphoid organs. Here the authors show that this differentiation process and related transcription programs are modulated by the transcription factor
Arantxa Pérez-García   +5 more
doaj   +6 more sources

Antibody Response following Exposure to SARS-CoV-2: Is It a Reliable Marker of Immunity? [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2022
Introduction: Infection and vaccination with the viral vector vaccine Covishield are both expected to produce immunity in the body against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).
Mona Dhakal   +2 more
doaj   +1 more source

Ovarian Diffuse Large B-cell Lymphoma Initially Suspected Dysgerminoma Managed by Laparoscopic Staging Surgery

open access: yesGynecology and Minimally Invasive Therapy, 2020
Ovarian diffuse large B-cell lymphoma (DLBCL) is rare. DLBCL is a complex type of lymphoma. The ovarian DLBCL usually harbor a favorable prognosis. We report a case of ovarian DLBCL that presented as an ovarian mass with lower abdominal pain and was ...
Pei- Chen Li   +3 more
doaj   +1 more source

Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells? [PDF]

open access: yesThe Journal of Immunology, 2007
Abstract Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27−) B cells following stimulation in vitro, consistent with the ...
Stuart G, Tangye, Kim L, Good
openaire   +2 more sources

B cell targeted therapy for immunoglobulin G4-related disease

open access: yesImmunological Medicine, 2021
Glucocorticoids are the first-line drug for the remission induction therapy of immunoglobulin (Ig) G4-related disease. Achieving drug-free remission using glucocorticoids alone is difficult, however, and many patients require maintenance therapy with ...
Motohisa Yamamoto
doaj   +1 more source

The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases

open access: yesAutoimmunity, 2023
The Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration.
Yunfei Li   +7 more
doaj   +1 more source

An isolated burkitt's iymphoma of the chest wall: First case reported in a malagasy child [PDF]

open access: yesJournal of Cardio-Thoracic Medicine, 2020
Primary Burkitt lymphomas of the chest wall are relatively rare in occurrence. The authors describe a first case report in Malagasy child. It presents as an isolated soft-tissue mass on the chest wall with a sudden installation of paraplegia in an 8-year-
Narindra Njarasoa Mihaja Razafimanjato   +4 more
doaj   +1 more source

Evaluation of the protective potential of antibody and T cell responses elicited by a novel preventative vaccine towards respiratory syncytial virus small hydrophobic protein

open access: yesHuman Vaccines & Immunotherapeutics, 2020
The small hydrophobic (SH) glycoprotein of human respiratory syncytial virus (RSV) is a transmembrane protein that is poorly accessible by antibodies on the virion but has an ectodomain (SHe) that is accessible and expressed on infected cells.
Heather L. Torrey   +9 more
doaj   +1 more source

AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins

open access: yesBiomolecules, 2021
An inappropriate response to progestogens in the human endometrium can result in fertility issues and jeopardize progestin-based treatments against pathologies such as endometriosis.
Charlotte Thieffry   +7 more
doaj   +1 more source

Role of B cell activating factor in the development of periodontitis

open access: yes口腔疾病防治, 2020
B cell activating factor (BAFF) is the key regulator of B cells and is considered as a potential therapeutic target for immune inflammatory diseases.
ZHANG Zheng, WANG Zuomin
doaj   +1 more source

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