Results 11 to 20 of about 21,583,992 (313)

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells [PDF]

, 2021
B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, by combining single-cell RNA and B
Greiff, Victor,, Borcherding, Nicholas, Bernasconi, Valentina, Lebrero-Fern\ue1ndez, Cristina, Smirnov, Ilya, Lebrero-Fernández, Cristina,, Mathew, Nimitha R.,, Schön, Karin,, Nakka, Sravya S.,, Jayanthan, Jayalal K., Yewdell, Jonathan W.,, Lebrero-Fernández, Cristina, Axelsson, Hannes, Yewdell, Jonathan W., Robinson, Jonathan, Rodin, William, Czarnewski, Paulo, Greiff, Victor, Angeletti, Davide,, Harandi, Ali M., Kalathilparambil Jayanthan, Jayalal, Rodin, William,, Robinson, Jonathan,, Bernasconi, V.,, Borcherding, Nicholas,, Axelsson, Hannes,, Lycke, Nils, Robinson, Jonathan L., Czarnewski, Paulo,, Angeletti, Davide, Sch\uf6n, Karin, Bernasconi, V., Smirnov, Ilya V., Smirnov, Ilya V.,, Lycke, N. Y.,, Yewdell, William T.,, Bemark, Mats, Nakka, Sravya S., Schön, Karin, Lycke, Nils Y., Yewdell, William T., Emmanouilidi, Aikaterini, Lycke, N. Y., Mathew, Nimitha R., Harandi, A. M., Bemark, Mats,, Harandi, A. M.,, Emmanouilidi, Aikaterini,, Jayanthan, Jayalal K.,   +48 more
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B cells and cancer [PDF]

Cancer Cell, 2021
Tumor-infiltrating B cells complement T cell-mediated antitumor immunity. A panel of experts share their views on the complexity of B cells within the tumor microenvironment, the variety of mechanisms by which these cells control tumor growth, their organization in tertiary lymphoid structures, and their association with immunotherapy response.
Engelhard, Victor, Conejo-Garcia, Jose R, Ahmed, Rafi, Nelson, Brad H, Willard-Gallo, Karen, Bruno, Tullia C, Fridman, Wolf Herman   +6 more
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Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells? [PDF]

The Journal of Immunology, 2007
Abstract Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27−) B cells following stimulation in vitro, consistent with the ...
Stuart G, Tangye, Kim L, Good
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Stromal Cells Attract B‐Cell Progenitors to Promote B‐Cell–B‐Cell Contact and Maturation [PDF]

Scandinavian Journal of Immunology, 2005
AbstractThe in vitro differentiation of B‐lineage progenitors into Ig‐secreting mature B cells has classically required a co‐culture system containing lipopolysaccharide (LPS) and stromal cells. We have previously showed that B‐lineage progenitors cultured in round‐bottomed wells can mature and secrete immunoglobulin M (IgM) on par with cultures ...
C D, Milne, Y, Zhang, C J, Paige
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Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Lane, P., McConnell, F., Padovan, E., Lanzavecchia, A., Brocker, Thomas, Hubele, S.   +5 more
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Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma [PDF]

, 2021
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism underpinning therapeutic response.
Schnidrig, D, Sunderland, MW, Ghorani, E, Lingard, K, Rowan, A, Jamal-Hanjani, M, Litchfield, K, Turajlic, S, Becker, PD, Swanton, C, Borg, E, PEACE Consortium, Hatipoglu, E, Mahadeva, U, Xu, H, Hazell, S, Mitchison, M, Green, A, TRACERx Renal Consortium, Reading, JL, Sarker, S, Robert de Massy, M, Nicol, D, TRACERx Renal Consortium,, Falzon, M, López, JI, Edmonds, K, Carlyle, E, Mason, R, Salgado, R, Vasquez, MD, Uddin, I, Au, L, Proctor, I, Yang, WW, Quezada, SA, Spencer, C, Fotiadis, N, Shepherd, STC, Mangwende, M, Dhillon, K, Joshi, K, Lund, T, Byrne, F, Horswell, S, Beattie, G, Moore, DA, PEACE Consortium,, Furness, AJS, Puccio, I, Akarca, A, Thompson, R, Larkin, J, Chain, B, Del Rosario, L, Fendler, A, Pickering, L, Kassiotis, G, Marafioti, T, Attig, J   +59 more
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CVID-associated TACI mutations affect autoreactive B cell selection and activation [PDF]

, 2013
Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity.
Tuure Kinnunen, Gentile, M, Cantaert, T, Tineke Cantaert, Menard, L, Laurence Menard, Morbach, H, Saadoun, D, Virdee, M, Neil Romberg, Kinnunen, T, Maurizio Gentile, Rachid, R, Martinez-Pomar, N, Geha, R, Henner Morbach, Matamoros, N, Cunningham-Rundles, C, Nicolas Chamberlain, Nuria Matamoros, Andrea Cerutti, Yen Shing Ng, Bodo Grimbacher, Natalia Martinez-Pomar, Meffre, E, Eric Meffre, David Saadoun, Manmeet Virdee, Rima Rachid, Cerutti, A, Raif Geha, Romberg, N, Brimbacher, B, Chamberlain, N, Charlotte Cunningham-Rundles, Ng, YS   +35 more
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Primary CNS Extranodal Marginal Zone B-Cell Lymphoma: A Case Series of 2 Patients Treated with External Beam Radiation Therapy

Case Reports in Oncology, 2021
Primary CNS extranodal marginal zone B-cell lymphoma (MZBL) is a rare low-grade non-Hodgkin lymphoma characterized predominantly by small B cells, plasma cells, monocytoid cells, and scattered large immunoblasts.
Rojine Ariani, Leslie Ballas
doaj   +1 more source

Inhibition of T cell/B cell interaction by B-CLL cells [PDF]

Leukemia, 1999
The course of disease in patients suffering from chronic lymphocytic leukemia (CLL) is determined by a profound dysregulation of the immune system. The resulting immune suppression is the main cause of death in those patients. In the present study we addressed the question of whether leukemic B cells (B-CLL) are able to suppress regular T cell/B cell ...
C, Kneitz, M, Goller, M, Wilhelm, C, Mehringer, G, Wohlleben, A, Schimpl, H P, Tony   +6 more
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Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity. [PDF]

, 2012
Despite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels.
Findlow, J., Helen Findlow, Findlow, H., James B Wing, Findlow Jamie, Read, Robert C., Helen Findlow (184554), Read Robert C., Wing, J.B., Borrow, Ray, Heath, A.W., James B. Wing, Robert C. Read (145234), Borrow Ray, Read, R.C., Andrew Lees, Smart Lynne, Borrow, R., Heath, Andrew W., Lynne Smart, Lees, Andrew, Jennifer Carlring, Findlow, Helen, James B. Wing (184537), Wing James B., Findlow, Jamie, Ray Borrow, Robert C. Read, Heath Andrew W., Smart, L., Lees Andrew, Lynne Smart (184541), Ray Borrow (49342), Andrew W. Heath (184566), Jamie Findlow (184547), Smart, Lynne, Lees, A., Andrew Lees (184562), Andrew W Heath, Wing, James B., Andrew W. Heath, Robert C Read, Rachel A Foster, Findlow Helen, Jamie Findlow   +44 more
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