Results 21 to 30 of about 9,437,655 (307)

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival [PDF]

, 2015
B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and 2 suggested that activation of ERK 1 and 2 MAP ...
Jacque, E, Ley, SC, Schweighoffer, E, Tybulewicz, VL   +3 more
core   +1 more source

Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]

Journal of Internal Medicine, 2017
AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman, M. Hallek, M. Dreyling, C. Thieblemont, E. Kimby, L. Staudt   +5 more
openaire   +3 more sources

Unique B cell responses in B cell-dependent and B cell-independent EAE

Autoimmunity, 2011
Previous studies characterized B cell-dependent and B cell-independent models of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. To further characterize the B cell response generated in these two models, the serum antibody response and the B cell surface immunoglobulin (Ig) repertoire were analyzed following immunization of wild-type ...
Guorong, Liu, Kamaldeen A, Muili, Vrushali V, Agashe, Jeri-Anne, Lyons   +3 more
openaire   +2 more sources

The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation [PDF]

European Journal of Immunology, 2000
B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. for VpreB, lambda5, or muH chains, do
R, Ceredig, A G, Rolink, F, Melchers, J, Andersson   +3 more
openaire   +2 more sources

Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease. [PDF]

, 2018
The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their recovery in different immune compartments is largely unknown ...
Bernard, Claude CA, Brück, Wolfgang, Feldmann, Linda, Häusler, Darius, Häusser-Kinzel, Silke, Lehmann-Horn, Klaus, Lepennetier, Gildas, Torke, Sebastian, Weber, Martin S, Zamvil, Scott S   +9 more
core   +1 more source

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers. [PDF]

, 2013
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-
Adler, Thure, Amodio, Stefania, Betsholtz, Christer, Betsholtz, Ingrid Holmberg, Busch, Dirk H., Casola, Stefano, Castelletti, Daniela, Di Fiore, Pier Paolo, Fuchs, Helmut, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Lucano, Caterina, Offenhäuser, Nina, Pozzi, Benedetta, Rathkolb, Birgit, Ronzoni, Simona, Sciullo, Anna, Treise, Irina, Wolf, Eckhard   +18 more
core   +5 more sources

B cells and cancer [PDF]

Cancer Cell, 2021
Tumor-infiltrating B cells complement T cell-mediated antitumor immunity. A panel of experts share their views on the complexity of B cells within the tumor microenvironment, the variety of mechanisms by which these cells control tumor growth, their organization in tertiary lymphoid structures, and their association with immunotherapy response.
Engelhard, Victor, Conejo-Garcia, Jose R, Ahmed, Rafi, Nelson, Brad H, Willard-Gallo, Karen, Bruno, Tullia C, Fridman, Wolf Herman   +6 more
openaire   +2 more sources

BCL-W has a fundamental role in B cell survival and lymphomagenesis. [PDF]

, 2017
Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival.
Annette S. Kim, Barrett, Christine M. Eischen, Clare M. Adams, Gibson, Haldar, Jerald Z. Gong, John K. Choi, Lee, Placzek, Ramkrishna Mitra, Schmitz, Visco, Wang, Yang   +14 more
core   +2 more sources

Differences in B-Cell Immunophenotypes and Neutralizing Antibodies Against SARS-CoV-2 After Administration of BNT162b2 (Pfizer-BioNTech) Vaccine in Individuals with and without Prior COVID-19 - A Prospective Cohort Study

Journal of Inflammation Research, 2022
José Javier Morales-Núñez,1 Mariel García-Chagollán,1 José Francisco Muñoz-Valle,1 Saúl Alberto Díaz-Pérez,1 Paola Carolina Torres-Hernández,2 Saraí Citlalic Rodríguez-Reyes,3 Guillermo Santoscoy-Ascencio,4 José Julio Sierra García de Quevedo,4 Jorge ...
Morales-Núñez JJ, García-Chagollán M, Muñoz-Valle JF, Díaz-Pérez SA, Torres-Hernández PC, Rodríguez-Reyes SC, Santoscoy-Ascencio G, Sierra García de Quevedo JJ, Hernández-Bello J   +8 more
doaj  

B cells and autoimmunity [PDF]

Current Opinion in Immunology, 2011
There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletion, BAFF blockade, regulatory B ...
Shiv, Pillai, Hamid, Mattoo, Annaiah, Cariappa   +2 more
openaire   +2 more sources