Results 21 to 30 of about 21,583,992 (313)

Potential of B-cell-targeting therapy in overcoming multidrug resistance and tissue invasiveness associated with P-glycoprotein expressing-B cell compartments

Immunological Medicine, 2021
Rheumatoid arthritis (RA) is a systemic autoimmune mediated inflammatory disease characterized by progressive joint damage and extra-articular organ manifestations.
Shizuyo Tsujimura, Yoshiya Tanaka
doaj   +1 more source

The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation [PDF]

European Journal of Immunology, 2000
B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. for VpreB, lambda5, or muH chains, do
R, Ceredig, A G, Rolink, F, Melchers, J, Andersson   +3 more
openaire   +2 more sources

PI3K-C2 alpha Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation [PDF]

, 2018
Insulin resistance is a syndrome that affects multiple insulin target tissues, each having different biological functions regulated by insulin. A remaining question is to mechanistically explain how an insulin target cell/tissue can be insulin resistant ...
Berggren, PO, Leibiger, IB, Paschen, M, Yunn, NO, Lim, JH, Leibiger, B, Ryu, SH, Moede, T, Pereira, T   +8 more
core   +1 more source

miRNA-Based Therapies in B Cell Non-Hodgkin Lymphoma.

, 2020
Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment ...
Yébenes, Fuertes, Teresa, Ramiro, Almudena R, García-Yébenes Mena, Virginia Pilar   +3 more
core   +1 more source

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers. [PDF]

, 2013
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-
Eckhard Wolf, Pier Paolo Di Fiore, Treise, Irina, Helmut Fuchs, Offenhäuser, Nina, Simona Ronzoni, Thure Adler, Irina Treise, Betsholtz, Christer, Di Fiore, Pier Paolo, Busch, Dirk H., Martin Hrabě de Angelis, Lucano, Caterina, Amodio, Stefania, Adler, Thure, Caterina Lucano, Nina Offenhäuser, Betsholtz, Ingrid Holmberg, Rathkolb, Birgit, Pozzi, Benedetta, Daniela Castelletti, Castelletti, Daniela, Dirk H. Busch, Anna Sciullo, Ingrid Holmberg Betsholtz, Ronzoni, Simona, Christer Betsholtz, Stefano Casola, Birgit Rathkolb, Benedetta Pozzi, Sciullo, Anna, Fuchs, Helmut, Wolf, Eckhard, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Valérie Gailus-Durner, Casola, Stefano, Stefania Amodio   +37 more
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Unique B cell responses in B cell-dependent and B cell-independent EAE

Autoimmunity, 2011
Previous studies characterized B cell-dependent and B cell-independent models of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. To further characterize the B cell response generated in these two models, the serum antibody response and the B cell surface immunoglobulin (Ig) repertoire were analyzed following immunization of wild-type ...
Guorong, Liu, Kamaldeen A, Muili, Vrushali V, Agashe, Jeri-Anne, Lyons   +3 more
openaire   +2 more sources

Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]

Journal of Internal Medicine, 2017
AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman, M. Hallek, M. Dreyling, C. Thieblemont, E. Kimby, L. Staudt   +5 more
openaire   +3 more sources

Differences in B-Cell Immunophenotypes and Neutralizing Antibodies Against SARS-CoV-2 After Administration of BNT162b2 (Pfizer-BioNTech) Vaccine in Individuals with and without Prior COVID-19 - A Prospective Cohort Study

Journal of Inflammation Research, 2022
José Javier Morales-Núñez,1 Mariel García-Chagollán,1 José Francisco Muñoz-Valle,1 Saúl Alberto Díaz-Pérez,1 Paola Carolina Torres-Hernández,2 Saraí Citlalic Rodríguez-Reyes,3 Guillermo Santoscoy-Ascencio,4 José Julio Sierra García de Quevedo,4 Jorge ...
Morales-Núñez JJ, García-Chagollán M, Muñoz-Valle JF, Díaz-Pérez SA, Torres-Hernández PC, Rodríguez-Reyes SC, Santoscoy-Ascencio G, Sierra García de Quevedo JJ, Hernández-Bello J   +8 more
doaj  

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

, 2020
Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive.
Jiang, Jue, Han, Meng, Wang, Yanwu, Zhang, Yingchi, Feng, Hui, Zhu, Xiaofan, Qing, Guoliang, Sun, Yonghua, Wu, Chao, Yue, Ming, Cai, Xiaolian, Jiang, Peng, Wang, Tianci, Li, Peng, Liu, Hudan, Su, Hexiu, Wang, Jingchao, Xiao, Wuhan   +17 more
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The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death [PDF]

, 2008
Autophagy is important for the degradation of bulk cytoplasm, long-lived proteins, and entire organelles. In lower eukaryotes, autophagy functions as a cell death mechanism or as a stress response during development.
Cecconi, F, Levine, B, Levine, B., Cecconi, Francesco, Levine, Beth   +4 more
core   +1 more source