Results 1 to 10 of about 774,459 (219)
Some of the next articles are maybe not open access.
The B-cell antigen receptor complex
Immunology Today, 1991Abstract Here, Michael Reth, John Cambier and colleagues review the genetics, biochemistry and cell biology o f the recently-identified accessory components o f the B-cell antigen receptor.
M, Reth +6 more
openaire +2 more sources
B Cell Receptor and Antigens in CLL
2013Nowadays, chronic lymphocytic leukemia (CLL) is considered as a prototypic antigen-driven lymphoma, with antigenic stimuli from the microenvironment promoting tumor outgrowth. Antigen recognition is a function of both the clonotypic B cell receptor immunoglobulin (BcR IG) and various other immune sensors, e.g., the Toll-like receptors.
Andreas, Agathangelidis +2 more
openaire +2 more sources
Current Opinion in Immunology, 1994
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
openaire +2 more sources
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
openaire +2 more sources
Structural principles of B cell antigen receptor assembly
Nature, 2022The B cell antigen receptor (BCR) is composed of a membrane-bound class M, D, G, E or A immunoglobulin for antigen recognition1-3 and a disulfide-linked Igα (also known as CD79A) and Igβ (also known as CD79B) heterodimer (Igα/β) that functions as the signalling entity through intracellular immunoreceptor tyrosine-based activation motifs (ITAMs)4,5. The
Ying Dong +8 more
openaire +3 more sources
Association of CD22 with the B cell antigen receptor
European Journal of Immunology, 1993AbstractThe antigen receptor on B lymphocytes is composed of membrane immunoglobulin sheathed by an α/β heterodimer. This structure is in several respects analogous to the antigen receptor on T cells except that, in the case of the T cell but not the B cell receptor, several receptor‐associated proteins have been described which may modulate the ...
C J, Peaker, M S, Neuberger
openaire +2 more sources
Stability of the B cell antigen receptor complex
Molecular Immunology, 2000The B cell antigen receptor (BCR) comprises the membrane-bound immunoglobulin (mIg) molecule and the Ig-alpha/Ig-beta heterodimer. By comparing the stability of the IgD-BCR and IgM-BCR in different detergent lysates, we find that the IgD-BCR is more stable than the IgM-BCR.
W W, Schamel, M, Reth
openaire +2 more sources
Compartmentalization of B-cell antigen receptor functions
Molecular Immunology, 1996Receptor tyrosine kinases (RTK), like the PDGF-receptor, translate information from the extracellular environment into cytoplasmic signals that regulate a spectrum of cellular functions. RTK molecules consist of ligand binding extracellular domains, cytoplasmic kinase domains and tyrosine phosphorylation sites [Ullrich and Schlessinger, 1990 (Cell 61 ...
Lankester, A. C., van Lier, R. A.
openaire +3 more sources