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Antigen anisotropy: The overlooked geometric determinant of vaccine immunogenicity and fidelity

open access: yesHuman Vaccines & Immunotherapeutics
Antigen anisotropy, the directional dependence of protein conformation, epitope exposure, and conformational dynamics, is an under-appreciated determinant of vaccine immunogenicity.
Daniel Santiago
doaj   +1 more source

Tuning B cell responsiveness by antigen receptor isotype

open access: yesOncotarget, 2015
The expression of functional B cell antigen receptors (BCRs) is essential for development, survival and activation of B cells. During early developmental stages, immature B cells exclusively express IgM. Cells that pass the immature B cell stage and leave the bone marrow coexpress BCRs of IgM and IgD isotypes, which differ in the usage of the heavy ...
openaire   +2 more sources

TAMing the tumor: targeting immune inhibitory receptors on tumor-associated macrophages in pediatric brain tumors - an emerging immunotherapy strategy. [PDF]

open access: yesJ Immunother Cancer
Mooij L   +6 more
europepmc   +1 more source

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