Results 21 to 30 of about 18,808,464 (300)

Characterisation of CD8neg and CD8+ human natural killer cell subsets [PDF]

, 2012
NK cells are CD3neg CD56+ lymphocytes that constitute about 10-15% of peripheral blood lymphocytes. They have an innate ability to recognise and kill virus infected cells and tumour cells.
Abdalla, Ibrahim.I.I.
core   +5 more sources

Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells [PDF]

, 2021
B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, by combining single-cell RNA and B
Greiff, Victor,, Borcherding, Nicholas, Bernasconi, Valentina, Lebrero-Fern\ue1ndez, Cristina, Smirnov, Ilya, Lebrero-Fernández, Cristina,, Mathew, Nimitha R.,, Schön, Karin,, Nakka, Sravya S.,, Jayanthan, Jayalal K., Yewdell, Jonathan W.,, Lebrero-Fernández, Cristina, Axelsson, Hannes, Yewdell, Jonathan W., Robinson, Jonathan, Rodin, William, Czarnewski, Paulo, Greiff, Victor, Angeletti, Davide,, Harandi, Ali M., Kalathilparambil Jayanthan, Jayalal, Rodin, William,, Robinson, Jonathan,, Bernasconi, V.,, Borcherding, Nicholas,, Axelsson, Hannes,, Lycke, Nils, Robinson, Jonathan L., Czarnewski, Paulo,, Angeletti, Davide, Sch\uf6n, Karin, Bernasconi, V., Smirnov, Ilya V., Smirnov, Ilya V.,, Lycke, N. Y.,, Yewdell, William T.,, Bemark, Mats, Nakka, Sravya S., Schön, Karin, Lycke, Nils Y., Yewdell, William T., Emmanouilidi, Aikaterini, Lycke, N. Y., Mathew, Nimitha R., Harandi, A. M., Bemark, Mats,, Harandi, A. M.,, Emmanouilidi, Aikaterini,, Jayanthan, Jayalal K.,   +48 more
core   +1 more source

The second touch hypothesis: T cell activation, homing and polarization [v1; ref status: indexed, http://f1000r.es/2w7]

F1000Research, 2014
The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj   +1 more source

Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFκB activity in vertebrate B-cells [PDF]

, 2007
To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A ...
Scharenberg, Andrew M., Cantrell, Doreen A., Liu, Ping, Matthews, Sharon A.   +3 more
core   +1 more source

TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.

PLoS ONE, 2009
TNF receptor superfamily members, such as CD40 and the Toll-like receptors (TLRs), regulate many aspects of B cell differentiation and activation. TRAF6 is an intracellular signaling adaptor molecule for these receptors, but its role in B cells has not ...
Takashi Kobayashi, Tae Soo Kim, Anand Jacob, Matthew C Walsh, Yuho Kadono, Ezequiel Fuentes-Pananá, Tomoko Yoshioka, Akihiko Yoshimura, Masahiro Yamamoto, Tsuneyasu Kaisho, Shizuo Akira, John G Monroe, Yongwon Choi   +12 more
doaj   +1 more source

Detection, sorting, and immortalization of dual expresser lymphocytes from human peripheral blood samples

STAR Protocols, 2021
Summary: This protocol describes how to identify Dual Expressers (DEs), a rare type of lymphocyte that co-expresses B-cell receptors and T-cell receptors, by flow cytometry using a cocktail of four antibodies. It also shows the subsequent gating strategy
Rizwan Ahmed, Kusuma Ananth, Zahra Omidian, Neha Majety, Hao Zhang, Abdel Rahim A. Hamad   +5 more
doaj   +1 more source

The effect of manipulating apoptotic cell uptake on their immunogenicity [PDF]

, 2009
Failure of the immune system to differentiate between apoptotic tumour cells and cells rendered apoptotic as part of homeostasis prevents a successful response being mounted against tumours.
Attfield, Kathrine Elizabeth
core   +1 more source

The second touch hypothesis: T cell activation, homing and polarization [v2; ref status: indexed, http://f1000r.es/3zq]

F1000Research, 2014
The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj   +1 more source

Activation of the Rap1 GTPase by the B Cell Antigen Receptor [PDF]

Journal of Biological Chemistry, 1998
The B cell antigen receptor (BCR) activates Ras, a GTPase that promotes cell proliferation by activating the Raf-1/MEK/ERK signaling module and other signaling enzymes. In its active GTP-bound form, the Rap1 GTPase may act as a negative regulator of Ras-mediated signaling by sequestering Ras effectors (e.g., Raf-1) and preventing their activation.
McLeod, S.J., Ingham, R.J., Bos, J.L., Kurisaki, T., Gold, M.R.   +4 more
openaire   +3 more sources

Silenced B-cell receptor response to autoantigen in a poor-prognostic subset of chronic lymphocytic leukemia

Haematologica, 2014
Chronic lymphocytic leukemia B cells express auto/xeno antigen-reactive antibodies that bind to self-epitopes and resemble natural IgM antibodies in their repertoire.
Ann-Charlotte Bergh, Chamilly Evaldsson, Lone Bredo Pedersen, Christian Geisler, Kostas Stamatopoulos, Richard Rosenquist, Anders Rosén   +6 more
doaj   +1 more source