Results 41 to 50 of about 18,808,464 (300)

B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates

, 2022
HIV-1 envelope (Env) proteins designed to induce neutralizing antibody responses allow study of the role of affinities (equilibrium dissociation constant [KD]) and kinetic rates (association/dissociation rates) on B cell antigen recognition.
Verkoczy, Laurent, Hossain, Md. Alamgir, Ortiz, Yaneth, Sanders, Rogier W., Kane, Advaiti Pai, Anasti, Kara, Easterhoff, David, Cronin, Kenneth, Schief, William R., Reth, Michael, Groschel, Bettina, Watts, Brian, Saunders, Kevin, Alam, S. Munir, Edwards, Robert J., Derking, Ronald, Rountree, Wes, Zhang, Jinsong, Kara Anasti, Brian Watts, David Easterhoff, Yaneth Ortiz, Wes Rountree, Michael Reth, Laurent Verkoczy, Bettina Groschel, Rogier W. Sanders, S. Munir Alam, Ronald Derking, R.J. Edwards, William R. Schief, Kenneth Cronin, Md. Alamgir Hossain, Kevin Saunders, Advaiti Pai Kane, Jinsong Zhang   +35 more
core   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]

, 2013
Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Cols, M, Cerutti, A, Andrea Cerutti, Puga, I, Montserrat Cols, Irene Puga   +5 more
core   +1 more source

NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting [PDF]

, 2020
Antigen stimulation (signal 1) triggers B cell proliferation and primes B cells to recruit, engage and respond to T cell help (signal 2). Failure to receive signal 2 within a defined time window results in B cell apoptosis, yet the mechanisms that ...
Mark Noviski, Vykunta, Vivasvan, Garcia, Jose, Zikherman, Julie, Julie Zikherman, Jose Garcia, Kenta Hibiya, Cheryl Heyn, Li, Zhongmei, Noviski, Mark, Corey Tan, Ryosuke Hiwa, Tan, Corey, Jeremy F. Brooks, Huizar, John, Heyn, Cheryl, Alexander Marson, Brooks, Jeremy F, Marson, Alexander, Hiwa, Ryosuke, Mueller, James L, John Huizar, Zhongmei Li, James L. Mueller, Hibiya, Kenta, Vivasvan Vykunta   +25 more
core   +1 more source

Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma

Nature Communications, 2020
Nodular lymphocyte-predominant Hodgkin lymphoma with IgD+ lymphocyte-predominant (LP) cells is a rare clinical distinct lymphoma subset of B-cell origin.
Lorenz Thurner, Sylvia Hartmann, Natalie Fadle, Evi Regitz, Maria Kemele, Yoo-Jin Kim, Rainer Maria Bohle, Anna Nimmesgern, Lutz von Müller, Volkhard A. J. Kempf, Marc A. Weniger, Frank Neumann, Nadine Schneider, Martine Vornanen, Christer Sundström, Laurence de Leval, Andreas Engert, Dennis A. Eichenauer, Ralf Küppers, Klaus-Dieter Preuss, Martin-Leo Hansmann, Michael Pfreundschuh   +21 more
doaj   +1 more source

Targeting human langerin promotes HIV-1 specific humoral immune responses.

PLoS Pathogens, 2021
The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb).
Jérôme Kervevan, Aurélie Bouteau, Juliane S Lanza, Adele Hammoudi, Sandra Zurawski, Mathieu Surenaud, Lydie Dieudonné, Marion Bonnet, Cécile Lefebvre, Hakim Hocini, Romain Marlin, Aurélie Guguin, Barbara Hersant, Oana Hermeziu, Elisabeth Menu, Christine Lacabaratz, Jean-Daniel Lelièvre, Gerard Zurawski, Véronique Godot, Sandrine Henri, Botond Z Igyártó, Yves Levy, Sylvain Cardinaud   +22 more
doaj   +1 more source

Recognition of antigen-specific B-cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates [PDF]

, 2014
SummaryIn patients with chronic lymphocytic leukemia (CLL), a single neoplastic antigen-specific B cell accumulates and overgrows other B cells, leading to immune deficiency.
Peng, H., Rader, C., Chiorazzi, N., Liu, Y., Kodadek, T., Sarkar, M., Morimoto, J., Aquino, C.   +7 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Can We Improve Vaccine Efficacy by Targeting T and B Cell Repertoire Convergence?

Frontiers in Immunology, 2019
Traditional vaccine development builds on the assumption that healthy individuals have virtually unlimited antigen recognition repertoires of receptors in B cells and T cells [the B cell receptor (BCR) and TCR respectively].
Katja Fink
doaj   +1 more source

B‐cell antigen‐receptor signalling in lymphocyte development [PDF]

Immunology, 2003
SummarySignalling through the B‐cell antigen receptor (BCR) is required throughout B‐cell development and peripheral maturation. Targeted disruption of BCR components or downstream effectors indicates that specific signalling mechanisms are preferentially required for central B‐cell development, peripheral maturation and repertoire selection ...
Leo D, Wang, Marcus R, Clark
openaire   +2 more sources