Results 21 to 30 of about 2,912,674 (304)

The role of B cell antigen receptors in mantle cell lymphoma

Journal of Hematology & Oncology, 2017
Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistance to currently available therapies in most cases.
Michael Fichtner, Martin Dreyling, Mascha Binder, Martin Trepel   +3 more
doaj   +1 more source

Chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma: opportunities and challenges

Drugs in Context, 2019
B-cell non-Hodgkin lymphoma (NHL) is the most frequent hematologic malignancy. Despite the refinement of chemoimmunotherapy, a substantial number of patients experience chemorefractory disease.
Shinichi Makita, Katsuaki Imaizumi , Saiko Kurosawa, Kensei Tobinai   +3 more
doaj   +1 more source

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. [PDF]

, 2017
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown.
Brennan, Cameron W., Campos, Carl, Clark, Owen, Codega, Paolo, DeAngelis, Lisa M., Dogan, Ahmet, Gavrilovic, Igor T., Glass, Jon, Graeber, Thomas G., Grommes, Christian, Gutin, Philip H., Hamlin, Paul, Hatzoglou, Vaios, Hsieh, Wan-Ying, Huse, Jason T., Kaley, Thomas J., Lallana, Enrico C., Mellinghoff, Ingo K., Moskowitz, Craig H., Nichol, Donna, Nolan, Craig P., Noy, Ariela, Omuro, Antonio, Palaskas, Nicolaos, Palomba, M. Lia, Panageas, Katherine S., Pastore, Alessandro, Peak, Scott, Pentsova, Elena, Reiner, Anne S., Rohle, Dan, Rosenblum, Marc, Sauter, Craig S., Schartz, Derrek, Schultz, Nikolaus, Tabar, Viviane S., Tang, Sarah S., Thomas, Alissa A., Tsyvkin, Elina, Viale, Agnes, Wolfe, Julia, Won, Minhee   +41 more
core   +2 more sources

The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation [PDF]

European Journal of Immunology, 2000
B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. for VpreB, lambda5, or muH chains, do
R, Ceredig, A G, Rolink, F, Melchers, J, Andersson   +3 more
openaire   +2 more sources

Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation

Autoimmunity, 2019
Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen presenting cells.
Theodoros Eleftheriadis, Georgios Pissas, Sotirios Zarogiannis, Vassilios Liakopoulos, Ioannis Stefanidis   +4 more
doaj   +1 more source

Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]

Journal of Internal Medicine, 2017
AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman, M. Hallek, M. Dreyling, C. Thieblemont, E. Kimby, L. Staudt   +5 more
openaire   +3 more sources

B cell activation and affinity discrimination by receptor segregation? [PDF]

, 2005
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Gruhn, T., Iber, D., Lipowsky, R., Maini, P. K.   +3 more
core   +1 more source

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival [PDF]

, 2015
B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and 2 suggested that activation of ERK 1 and 2 MAP ...
Jacque, E, Ley, SC, Schweighoffer, E, Tybulewicz, VL   +3 more
core   +1 more source

Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease. [PDF]

, 2018
The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their recovery in different immune compartments is largely unknown ...
Bernard, Claude CA, Brück, Wolfgang, Feldmann, Linda, Häusler, Darius, Häusser-Kinzel, Silke, Lehmann-Horn, Klaus, Lepennetier, Gildas, Torke, Sebastian, Weber, Martin S, Zamvil, Scott S   +9 more
core   +1 more source

Tfg (Trk fused gene) is a Carma-1/IKKgamma interacting protein involved in CD40-induced canonical NF-KB signaling [PDF]

, 2009
Carma-1 is required for B cell receptor-/CD40- and T cell receptor-/CD28-induced B- and T-cell activation via JNK and NF-betaB. In B cells, Carma-1 becomes phosphorylated by PKCbeta, leading to its oligomerization.
Grohmann, Marcus, Hampel, Martin, Hermann, Ingo, Jäck, Hans-Martin, Kalbacher, Hubert, Karas, Michael (Prof. Dr.), Mielenz, Dirk   +6 more
core   +1 more source