Results 21 to 30 of about 1,958,602 (263)
Autoimmunity, 2019 Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen presenting cells.
Theodoros Eleftheriadis +4 more
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Drugs in Context, 2019 B-cell non-Hodgkin lymphoma (NHL) is the most frequent hematologic malignancy. Despite the refinement of chemoimmunotherapy, a substantial number of patients experience chemorefractory disease.
Shinichi Makita +3 more
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B Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis [PDF]
The Journal of Immunology, 2009 Abstract B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and ...
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Unveiling the B cell receptor structure
Science, 2022 Molecular structures provide a road map for understanding and controlling B cell receptor ...
Tolar, P, Pierce, SK
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The pre‐B cell receptor checkpoint
FEBS Letters, 2010 B lymphocytes are essential antibody‐producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane‐bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign‐
Mårtensson, Inga-Lill +3 more
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Current Directions in Biomedical Engineering, 2015 Automated image processing methods enable objective, reproducible and high quality analysis of fluorescent cell images in a reasonable amount of time. Therefore, we propose the application of image processing pipelines based on established segmentation ...
Wiesmann Veit +5 more
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B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting
Cell Reports, 2018 Summary: Antigen-dependent engagement of germinal center (GC) B cell receptors (BCRs) promotes antigen internalization and presentation for follicular helper T cells.
Jackson Steed Turner +2 more
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Frontiers in Immunology, 2022 B cells can act as potent suppressors of anti-tumor T cell immunity, presenting a mechanism of resistance to immunotherapy. In pancreatic ductal adenocarcinoma, B cells can display a T cell-suppressive or regulatory phenotype centered on the expression ...
Daniel Michaud +6 more
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Regulation of B cell fate by chronic activity of the IgE B cell receptor
eLife, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Zhiyong Yang +6 more
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Method for B Cell Receptor Enrichment in Malignant B Cells. [PDF]
Cancers (Basel)B cells are central to the adaptive immune response and provide long-lasting immunity after infection. B cell activation is mediated by the surface membrane-bound B cell receptor (BCR) following recognition of a specific antigen. The BCR has been challenging to analyse using mass spectrometry (MS) due to the difficulty of isolating and enriching this ...
Bhattacharyya P +3 more
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