Results 11 to 20 of about 1,958,602 (263)
Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies [PDF]
Cancers, 2020 The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone B cell lymphoma, and Waldenstrom’s macroglobulinemia.
Dimitar G. Efremov +2 more
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The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation [PDF]
European Journal of Immunology, 2000 B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. for VpreB, lambda5, or muH chains, do
R, Ceredig +3 more
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Exploration of Immunology, 2023 Human germinal center (GC)-associated lymphoma (HGAL) is a multi-domain adaptor protein expressed in GC B lymphocytes, T follicular helper (Tfh) cells and lymphomas derived from these cells.
Xiaoyu Jiang, Izidore S. Lossos
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Revising B Cell Receptors [PDF]
The Journal of Experimental Medicine, 2000 B cell development is often portrayed as a series of decision points that expand an antigen-reactive cell to a clone producing a single antibody. This is hardly the case: B cell development is dependent on a series of error-prone, random rearrangement events that through ongoing ...
D, Nemazee, M, Weigert
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B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses
Emerging Microbes and Infections, 2022 Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those with strong antibody ...
Ke Lin +28 more
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Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]
Journal of Internal Medicine, 2017 AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman +5 more
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IgD shapes the pre-immune naïve B cell compartment in humans
Frontiers in Immunology, 2023 B cell maturation and immunoglobulin (Ig) repertoire selection are governed by expression of a functional B cell receptor (BCR). Naïve B cells co-express their BCR as IgM and IgD isotype.
Johannes Dirks +6 more
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Aberrant B-Cell Activation in Systemic Lupus Erythematosus
Kidney Diseases, 2022 Background: B lymphocytes (B cells) are essential in humoral response, and their activation is an important first step for the production of antibodies.
Na Kang +6 more
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Journal of Inflammation Research, 2022 Anqi Lin,1,* Jianbo Fang,1,* Quan Cheng,2,3 Zaoqu Liu,4 Peng Luo,1 Jian Zhang1 1Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Neurosurgery, Xiangya ...
Lin A +5 more
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The role of B cell antigen receptors in mantle cell lymphoma
Journal of Hematology & Oncology, 2017 Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistance to currently available therapies in most cases.
Michael Fichtner +3 more
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