Results 11 to 20 of about 1,968,688 (264)

Immunoglobulin M-degrading enzyme of Streptococcus suis (IdeSsuis) impairs porcine B cell signaling

Frontiers in Immunology, 2023
Streptococcus suis (S. suis) is an important porcine pathogen, causing severe disease like meningitis and septicemia primarily in piglets. Previous work showed that the IgM-degrading enzyme of S.
Annika Katharina Breitfelder, Wieland Schrödl, Viktoria Rungelrath, Christoph Georg Baums, Gottfried Alber, Nicole Schütze, Uwe Müller   +6 more
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Regulation of cell adhesion to galectins by glycosylation: A new concept in lymphoma cell adhesion

Advances in Cancer Biology - Metastasis, 2021
To investigate the biological roles of glycosylation in human lymphoma cell adhesion to galectins, I performed the cell adhesion assay using neuraminidase or glycosylation inhibitors on B cell lymphoma cell line.
Osamu Suzuki
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Role of an adaptor protein human germinal center-associated lymphoma (HGAL) in cell signaling and lymphomagenesis

Exploration of Immunology, 2023
Human germinal center (GC)-associated lymphoma (HGAL) is a multi-domain adaptor protein expressed in GC B lymphocytes, T follicular helper (Tfh) cells and lymphomas derived from these cells.
Xiaoyu Jiang, Izidore S. Lossos
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Revising B Cell Receptors [PDF]

The Journal of Experimental Medicine, 2000
B cell development is often portrayed as a series of decision points that expand an antigen-reactive cell to a clone producing a single antibody. This is hardly the case: B cell development is dependent on a series of error-prone, random rearrangement events that through ongoing ...
D, Nemazee, M, Weigert
openaire   +2 more sources

B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses

Emerging Microbes and Infections, 2022
Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those with strong antibody ...
Ke Lin, Yawen Zhou, Jingwen Ai, Yan A. Wang, Senxin Zhang, Chao Qiu, Chaoyang Lian, Bo Gao, Tingting Liu, Hongyu Wang, Haocheng Zhang, Yi Zhang, Zhangfan Fu, Dan Li, Ning Jiang, Jingxin Guo, Jing Wu, Yan O. Wang, Shusen Song, Qiang Li, Yanan Yin, Jia Xia, Yingjie Xu, Leng-Siew Yeap, Xiaoqi Zheng, Ye Gu, Hongyan Liu, Wenhong Zhang, Fei-Long Meng   +28 more
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Aberrant B-Cell Activation in Systemic Lupus Erythematosus

Kidney Diseases, 2022
Background: B lymphocytes (B cells) are essential in humoral response, and their activation is an important first step for the production of antibodies.
Na Kang, Xiaohang Liu, Xujie You, Wenbo Sun, Kabeer Haneef, Xiaolin Sun, Wanli Liu   +6 more
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Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]

Journal of Internal Medicine, 2017
AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman, M. Hallek, M. Dreyling, C. Thieblemont, E. Kimby, L. Staudt   +5 more
openaire   +3 more sources

IgD shapes the pre-immune naïve B cell compartment in humans

Frontiers in Immunology, 2023
B cell maturation and immunoglobulin (Ig) repertoire selection are governed by expression of a functional B cell receptor (BCR). Naïve B cells co-express their BCR as IgM and IgD isotype.
Johannes Dirks, Oliver Andres, Luisa Paul, Luisa Paul, Georgi Manukjan, Harald Schulze, Henner Morbach   +6 more
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B Cell Receptor Signaling Pathway Mutation as Prognosis Predictor of Immune Checkpoint Inhibitors in Lung Adenocarcinoma by Bioinformatic Analysis

Journal of Inflammation Research, 2022
Anqi Lin,1,* Jianbo Fang,1,* Quan Cheng,2,3 Zaoqu Liu,4 Peng Luo,1 Jian Zhang1 1Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Neurosurgery, Xiangya ...
Lin A, Fang J, Cheng Q, Liu Z, Luo P, Zhang J   +5 more
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The role of B cell antigen receptors in mantle cell lymphoma

Journal of Hematology & Oncology, 2017
Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistance to currently available therapies in most cases.
Michael Fichtner, Martin Dreyling, Mascha Binder, Martin Trepel   +3 more
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