Results 1 to 10 of about 12,131 (215)
B Cell Signaling and Activation in Autoimmunity
Cells, 2023 Autoreactive B cells play a key role in the initiation or aggravation of many systemic and tissue-specific autoimmune disorders [...]
Rudi W. Hendriks, Odilia B. J. Corneth
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A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells
Cells, 2023 CD30-positive germinal center (GC)-derived B cell lymphomas are frequently linked to Epstein–Barr Virus (EBV) infection. However, a suitable animal model for the investigation of the interplay between γ-herpesvirus and host cells in B cell pathogenesis ...
Ursula Rambold +8 more
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Immunomodulatory and therapeutic effects of embelin on systemic lupus erythematosus mice
Di-san junyi daxue xuebao, 2022 Objective To observe the immune regulation of embelin against systemic lupus erythematosus (SLE) in mice, so as to investigate its therapeutic effects on SLE and the possible mechanism.
SHEN Jie +4 more
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The microanatomy of B cell activation [PDF]
Current Opinion in Immunology, 2009 The logistic problem of B cell antigen encounter in the lymph node has recently been studied by dynamic imaging using two-photon microscopy. These studies combined with the early studies of antigen transport have yielded a more complete picture of the orchestration of B cell activation in vivo.
Tri Giang, Phan +2 more
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mAbs, 2022 A major impediment to successful use of therapeutic protein drugs is their ability to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a significant number of patients.
Axel Ducret +13 more
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Evolution of Human Memory B Cells From Childhood to Old Age
Frontiers in Immunology, 2021 High quality medical assistance and preventive strategies, including pursuing a healthy lifestyle, result in a progressively growing percentage of older people. The population and workforce is aging in all countries of the world.
Michela Ciocca +21 more
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Cells, 2020 Detection of antigen-specific memory B cells for immune monitoring requires their activation, and is commonly accomplished through stimulation with the TLR7/8 agonist R848 and IL-2.
Fridolin Franke +3 more
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Frontiers in Immunology, 2021 Primary HIV infection (PHI) and subsequent chronic infection alter B-cell compartment. However, longitudinal analysis defining the dynamics of B-cell alterations are still limited.
Montse Jiménez +15 more
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Glycerol monolaurate inhibition of human B cell activation
Scientific Reports, 2022 Glycerol monolaurate (GML) is a naturally occurring antimicrobial agent used commercially in numerous products and food items. GML is also used as a homeopathic agent and is being clinically tested to treat several human diseases. In addition to its anti-
Micaela G. Fosdick +4 more
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Immunological Reviews, 1975 SUMMARYWe consider that 2 'signals’are essential for B cell activation. 'Signal 1’is a consequence of appropriate latticing of surface immunoglobulin receptors. 'Signal 2’can be mediated by a variety of agents. Signal 1 alone (i.e. surface Ig aggregation) leads to a state of B cell tolerance.
Waldmann, H, Munro, A
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