Dendritic cell expression of MyD88 is required for rotavirus-induced B cell activation [PDF]
Journal of VirologyIntestinal IgA, produced by local intestinal B cells, is thought to play a major role in protection against intestinal infections. Rotavirus, a well-characterized intestinal virus, induces a rapid viral-specific intestinal IgA response that occurs in the
Sarah E. Blutt +2 more
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Leishmania donovani Exploits Tunneling Nanotubes for Dissemination and Propagation of B Cell Activation [PDF]
Microbiology Spectrum, 2023 Polyclonal B cell activation and the resulting hypergammaglobulinemia are a detrimental consequence of visceral leishmaniasis (VL); however, the mechanisms underlying this excessive production of nonprotective antibodies are still poorly understood. Here,
Tanja Stögerer +8 more
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Frontiers in Immunology, 2019 B-cell activation plays a crucial part in the immune system and is initiated via interaction between the B cell receptor (BCR) and specific antigens.
Jingwen Li +13 more
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Aberrant B-Cell Activation in Systemic Lupus Erythematosus [PDF]
Kidney Diseases, 2022 Background: B lymphocytes (B cells) are essential in humoral response, and their activation is an important first step for the production of antibodies.
Na Kang +6 more
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DNA methylation regulates B cell activation via repressing Pax5 expression in teleost [PDF]
Frontiers in ImmunologyIn mammals, the transcription factor Pax5 is a key regulator of B cell development and maturation and specifically expressed in naive/mature B cells but repressed upon B cell activation.
Yuan Shi +5 more
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Basophilic exosomes promote SLE development via exacerbating B cell activation through the lncRNA ENST00000537616/miR-330-5p/KRAS axis [PDF]
Journal of Advanced ResearchIntroduction: Uncontrolled B-cell activation in systemic lupus erythematosus (SLE) induces autoantibody production and inflammation and causes tissue damage. Basophils have been shown to promote B cell activation in SLE; however, the molecular mechanisms
Jiaxuan Chen +15 more
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Role of Rad18 in B cell activation and lymphomagenesis [PDF]
Scientific ReportsMaintenance of genome integrity is instrumental in preventing cancer. In addition to DNA repair pathways that prevent damage to DNA, damage tolerance pathways allow for the survival of cells that encounter DNA damage during replication.
Kevin Kalweit +3 more
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Editorial: Community series in BCR signaling and B cell activation, volume 2 [PDF]
Frontiers in ImmunologyWenxia Song +4 more
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A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells
Cells, 2023 CD30-positive germinal center (GC)-derived B cell lymphomas are frequently linked to Epstein–Barr Virus (EBV) infection. However, a suitable animal model for the investigation of the interplay between γ-herpesvirus and host cells in B cell pathogenesis ...
Ursula Rambold +8 more
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Immunomodulatory and therapeutic effects of embelin on systemic lupus erythematosus mice
Di-san junyi daxue xuebao, 2022 Objective To observe the immune regulation of embelin against systemic lupus erythematosus (SLE) in mice, so as to investigate its therapeutic effects on SLE and the possible mechanism.
SHEN Jie +4 more
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