Results 11 to 20 of about 2,252,807 (303)

B Cell Signaling and Activation in Autoimmunity

Cells, 2023
Autoreactive B cells play a key role in the initiation or aggravation of many systemic and tissue-specific autoimmune disorders [...]
Rudi W. Hendriks, Odilia B. J. Corneth
doaj   +4 more sources

Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

eLife, 2017
The mechanosensing ability of lymphocytes regulates their activation in response to antigen stimulation, but the underlying mechanism remains unexplored. Here, we report that B cell mechanosensing-governed activation requires BCR signaling molecules. PMA-
Samina Shaheen, Zhengpeng Wan, Zongyu Li, Alicia Chau, Xinxin Li, Shaosen Zhang, Yang Liu, Junyang Yi, Yingyue Zeng, Jing Wang, Xiangjun Chen, Liling Xu, Wei Chen, Fei Wang, Yun Lu, Wenjie Zheng, Yan Shi, Xiaolin Sun, Zhanguo Li, Chunyang Xiong, Wanli Liu   +20 more
doaj   +2 more sources

The microanatomy of B cell activation [PDF]

Current Opinion in Immunology, 2009
The logistic problem of B cell antigen encounter in the lymph node has recently been studied by dynamic imaging using two-photon microscopy. These studies combined with the early studies of antigen transport have yielded a more complete picture of the orchestration of B cell activation in vivo.
Tri Giang, Phan, Elizabeth E, Gray, Jason G, Cyster   +2 more
openaire   +2 more sources

Evolution of Human Memory B Cells From Childhood to Old Age

Frontiers in Immunology, 2021
High quality medical assistance and preventive strategies, including pursuing a healthy lifestyle, result in a progressively growing percentage of older people. The population and workforce is aging in all countries of the world.
Michela Ciocca, Salvatore Zaffina, Salvatore Zaffina, Ane Fernandez Salinas, Ane Fernandez Salinas, Chiara Bocci, Patrizia Palomba, Maria Giulia Conti, Maria Giulia Conti, Sara Terreri, Giuseppe Frisullo, Ezio Giorda, Marco Scarsella, Rita Brugaletta, Rita Brugaletta, Maria Rosaria Vinci, Maria Rosaria Vinci, Nicola Magnavita, Nicola Magnavita, Rita Carsetti, Rita Carsetti, Eva Piano Mortari   +21 more
doaj   +1 more source

Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays

mAbs, 2022
A major impediment to successful use of therapeutic protein drugs is their ability to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a significant number of patients.
Axel Ducret, Chloé Ackaert, Juliana Bessa, Campbell Bunce, Timothy Hickling, Vibha Jawa, Mark A. Kroenke, Kasper Lamberth, Anaïs Manin, Hweixian L. Penny, Noel Smith, Grzegorz Terszowski, Sophie Tourdot, Sebastian Spindeldreher   +13 more
doaj   +1 more source

B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue. [PDF]

J Inflamm Res
Peizhi Lu,1,2,* Ya Li,1,2,* Shuo Yang,2 Haoyu Yao,2 Bizhi Tu,2 Rende Ning1,2 1Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical ...
Lu P, Li Y, Yang S, Yao H, Tu B, Ning R.
europepmc   +2 more sources

IL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B Cells

Cells, 2020
Detection of antigen-specific memory B cells for immune monitoring requires their activation, and is commonly accomplished through stimulation with the TLR7/8 agonist R848 and IL-2.
Fridolin Franke, Greg A. Kirchenbaum, Stefanie Kuerten, Paul V. Lehmann   +3 more
doaj   +1 more source

A Longitudinal Analysis Reveals Early Activation and Late Alterations in B Cells During Primary HIV Infection in Mozambican Adults

Frontiers in Immunology, 2021
Primary HIV infection (PHI) and subsequent chronic infection alter B-cell compartment. However, longitudinal analysis defining the dynamics of B-cell alterations are still limited.
Montse Jiménez, Lucía Pastor, Lucía Pastor, Lucía Pastor, Victor Urrea, María Luisa Rodríguez de la Concepción, Erica Parker, Laura Fuente-Soro, Laura Fuente-Soro, Chenjerai Jairoce, Inacio Mandomando, Jorge Carrillo, Denise Naniche, Denise Naniche, Julià Blanco, Julià Blanco   +15 more
doaj   +1 more source

Personalized B cell response to the Lactobacillus rhamnosus GG probiotic in healthy human subjects: a randomized trial

Gut Microbes, 2020
The specific effects of administering live probiotics in the human gut are not well characterized. To this end, we investigated the immediate effect of Lactobacillus rhamnosus GG (LGG) in the jejunum of 27 healthy volunteers 2 h after ingestion using a ...
Jette Bornholdt, Christa Broholm, Yun Chen, Alfredo Rago, Stine Sloth, Jakob Hendel, Cathrine Melsæther, Christina V. Müller, Maria Juul Nielsen, Jesper Strickertsson, Lars Engelholm, Kristoffer Vitting-Seerup, Kim B. Jensen, Adam Baker, Albin Sandelin   +14 more
doaj   +1 more source

Glycerol monolaurate inhibition of human B cell activation

Scientific Reports, 2022
Glycerol monolaurate (GML) is a naturally occurring antimicrobial agent used commercially in numerous products and food items. GML is also used as a homeopathic agent and is being clinically tested to treat several human diseases. In addition to its anti-
Micaela G. Fosdick, Shannon Loftus, Isabella Phillips, Zeb R. Zacharias, Jon C. D. Houtman   +4 more
doaj   +1 more source