Results 11 to 20 of about 2,179,011 (259)

Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays

mAbs, 2022
A major impediment to successful use of therapeutic protein drugs is their ability to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a significant number of patients.
Axel Ducret, Chloé Ackaert, Juliana Bessa, Campbell Bunce, Timothy Hickling, Vibha Jawa, Mark A. Kroenke, Kasper Lamberth, Anaïs Manin, Hweixian L. Penny, Noel Smith, Grzegorz Terszowski, Sophie Tourdot, Sebastian Spindeldreher   +13 more
doaj   +1 more source

Evolution of Human Memory B Cells From Childhood to Old Age

Frontiers in Immunology, 2021
High quality medical assistance and preventive strategies, including pursuing a healthy lifestyle, result in a progressively growing percentage of older people. The population and workforce is aging in all countries of the world.
Michela Ciocca, Salvatore Zaffina, Salvatore Zaffina, Ane Fernandez Salinas, Ane Fernandez Salinas, Chiara Bocci, Patrizia Palomba, Maria Giulia Conti, Maria Giulia Conti, Sara Terreri, Giuseppe Frisullo, Ezio Giorda, Marco Scarsella, Rita Brugaletta, Rita Brugaletta, Maria Rosaria Vinci, Maria Rosaria Vinci, Nicola Magnavita, Nicola Magnavita, Rita Carsetti, Rita Carsetti, Eva Piano Mortari   +21 more
doaj   +1 more source

IL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B Cells

Cells, 2020
Detection of antigen-specific memory B cells for immune monitoring requires their activation, and is commonly accomplished through stimulation with the TLR7/8 agonist R848 and IL-2.
Fridolin Franke, Greg A. Kirchenbaum, Stefanie Kuerten, Paul V. Lehmann   +3 more
doaj   +1 more source

A Longitudinal Analysis Reveals Early Activation and Late Alterations in B Cells During Primary HIV Infection in Mozambican Adults

Frontiers in Immunology, 2021
Primary HIV infection (PHI) and subsequent chronic infection alter B-cell compartment. However, longitudinal analysis defining the dynamics of B-cell alterations are still limited.
Montse Jiménez, Lucía Pastor, Lucía Pastor, Lucía Pastor, Victor Urrea, María Luisa Rodríguez de la Concepción, Erica Parker, Laura Fuente-Soro, Laura Fuente-Soro, Chenjerai Jairoce, Inacio Mandomando, Jorge Carrillo, Denise Naniche, Denise Naniche, Julià Blanco, Julià Blanco   +15 more
doaj   +1 more source

Glycerol monolaurate inhibition of human B cell activation

Scientific Reports, 2022
Glycerol monolaurate (GML) is a naturally occurring antimicrobial agent used commercially in numerous products and food items. GML is also used as a homeopathic agent and is being clinically tested to treat several human diseases. In addition to its anti-
Micaela G. Fosdick, Shannon Loftus, Isabella Phillips, Zeb R. Zacharias, Jon C. D. Houtman   +4 more
doaj   +1 more source

B Cell Activation

Immunological Reviews, 1975
SUMMARYWe consider that 2 'signals’are essential for B cell activation. 'Signal 1’is a consequence of appropriate latticing of surface immunoglobulin receptors. 'Signal 2’can be mediated by a variety of agents. Signal 1 alone (i.e. surface Ig aggregation) leads to a state of B cell tolerance.
Waldmann, H, Munro, A
openaire   +3 more sources

Personalized B cell response to the Lactobacillus rhamnosus GG probiotic in healthy human subjects: a randomized trial

Gut Microbes, 2020
The specific effects of administering live probiotics in the human gut are not well characterized. To this end, we investigated the immediate effect of Lactobacillus rhamnosus GG (LGG) in the jejunum of 27 healthy volunteers 2 h after ingestion using a ...
Jette Bornholdt, Christa Broholm, Yun Chen, Alfredo Rago, Stine Sloth, Jakob Hendel, Cathrine Melsæther, Christina V. Müller, Maria Juul Nielsen, Jesper Strickertsson, Lars Engelholm, Kristoffer Vitting-Seerup, Kim B. Jensen, Adam Baker, Albin Sandelin   +14 more
doaj   +1 more source

Brg1 Supports B Cell Proliferation and Germinal Center Formation Through Enhancer Activation

Frontiers in Immunology, 2021
Activation and differentiation of B cells depend on extensive rewiring of gene expression networks through changes in chromatin structure and accessibility. The chromatin remodeling complex BAF with its catalytic subunit Brg1 was previously identified as
Dominik Schmiedel, Hadas Hezroni, Amit Hamburg, Ziv Shulman   +3 more
doaj   +1 more source

Interaction of B cells with activated T cells reduces the threshold for CD40-mediated B cell activation [PDF]

International Immunology, 1999
CD154-CD40 interactions are of central importance for the induction of antibody responses to T-dependent antigens. Since most anti-CD40 mAb are only weak B cell mitogens, it is believed that under physiological conditions, signals through CD40 synergize with those from other receptors on B cells to induce B cell activation.
G G, Klaus, M, Holman, C, Johnson-Léger, J R, Christenson, M R, Kehry   +4 more
openaire   +2 more sources

Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells

Cells, 2023
Lipopolysaccharide (LPS) stimulates dual receptor signaling by bridging the B cell receptor and Toll-like receptor 4 (BCR/TLR4). B cells from IκBNS-deficient bumble mice treated with LPS display reduced proliferative capacity and impaired plasma cell ...
Monika Adori, Sharesta Khoenkhoen, Jingdian Zhang, Xaquin Castro Dopico, Gunilla B. Karlsson Hedestam   +4 more
doaj   +1 more source