Immunological Reviews, 1975 SUMMARYWe consider that 2 'signals’are essential for B cell activation. 'Signal 1’is a consequence of appropriate latticing of surface immunoglobulin receptors. 'Signal 2’can be mediated by a variety of agents. Signal 1 alone (i.e. surface Ig aggregation) leads to a state of B cell tolerance.
Waldmann, H, Munro, A
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CVID-associated TACI mutations affect autoreactive B cell selection and activation [PDF]
, 2013 Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity.
Tuure Kinnunen +35 more
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Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J +11 more
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Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]
, 1993 We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Lane, P. +11 more
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Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton [PDF]
, 2010 Apicomplexan parasites within the genus <i>Theileria</i> have the ability to induce continuous proliferation and prevent apoptosis of the infected bovine leukocyte.
Weir, W. +8 more
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Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity. [PDF]
, 2012 Despite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels.
Findlow, J. +44 more
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Brg1 Supports B Cell Proliferation and Germinal Center Formation Through Enhancer Activation
Frontiers in Immunology, 2021 Activation and differentiation of B cells depend on extensive rewiring of gene expression networks through changes in chromatin structure and accessibility. The chromatin remodeling complex BAF with its catalytic subunit Brg1 was previously identified as
Dominik Schmiedel +3 more
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Interaction of B cells with activated T cells reduces the threshold for CD40-mediated B cell activation [PDF]
International Immunology, 1999 CD154-CD40 interactions are of central importance for the induction of antibody responses to T-dependent antigens. Since most anti-CD40 mAb are only weak B cell mitogens, it is believed that under physiological conditions, signals through CD40 synergize with those from other receptors on B cells to induce B cell activation.
G G, Klaus +4 more
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Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. [PDF]
, 2014 Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders ...
Susanne MA van der Pol +66 more
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Infection and the Perils of B-cell Activation [PDF]
Cancer Discovery, 2015 Abstract Summary: Recent studies have linked aberrant B-cell activation in the context of aberrant immune responses to infectious pathogens to malignant transformation and development of leukemia and lymphoma. A new study in this issue demonstrates that common infections can be drivers of clonal evolution of premalignant B-cell ...
Greaves, Mel, Müschen, Markus
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